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anti-Human TSC2 antibody for Enzyme Immunoassay

Recommended TSC2 Antibody (supplied by: Log in to see )

Antigen
Tuberous Sclerosis 2 (TSC2) Antibodies
  • fc16b02
  • LAM
  • Nafld
  • Rc
  • Tcs2
  • TSC2
  • TSC4
  • tuberin
  • wu:fc16b02
Epitope
pSer1420
41
40
27
27
26
24
22
22
22
21
20
20
20
20
20
20
20
20
20
18
18
17
16
15
15
15
13
13
13
13
11
8
8
6
6
6
6
6
6
6
6
6
6
5
4
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
505
374
207
6
Host
Rabbit
679
24
Clonality
Polyclonal
Conjugate
This TSC2 antibody is un-conjugated
51
51
51
42
42
42
9
9
9
9
9
9
9
9
9
Application
Enzyme Immunoassay (EIA)
384
291
215
132
101
59
48
9
6
6
4
2
1
Supplier
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Catalog No. ABIN358411
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008833851 ABIN358410 DB EIA Rabbit Ig pSer1798 Log in to see Polyclonal 5
0.0008833851 ABIN358353 EIA Rabbit Ig pSer939 Log in to see Polyclonal 5
0.0008833851 ABIN358936 EIA IHC (p) Rabbit Ig Ser1798 Log in to see Polyclonal 4
0.0008833851 ABIN358369 DB EIA Rabbit Ig pSer664 Log in to see Polyclonal 5
0.0008833851 ABIN501073 EIA WB Rabbit IgG C-Term Log in to see Polyclonal 4
0.0008833851 ABIN501075 EIA IF WB Rabbit IgG N-Term Log in to see Polyclonal 4

Top referenced anti-TSC2 antibody for Enzyme Immunoassay

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Application / Reactivity Human
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Enzyme Immunoassay (EIA) 7 Antibodies
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General

Antigen Tuberous Sclerosis 2 (TSC2) Antibodies
Epitope pSer1420
(41), (40), (27), (27), (26), (24), (22), (22), (22), (21), (20), (20), (20), (20), (20), (20), (20), (20), (20), (18), (18), (17), (16), (15), (15), (15), (13), (13), (13), (13), (11), (8), (8), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(505), (374), (207), (6)
Host Rabbit
(679), (24)
Clonality
Polyclonal
Conjugate This TSC2 antibody is un-conjugated
(51), (51), (51), (42), (42), (42), (9), (9), (9), (9), (9), (9), (9), (9), (9)
Application Enzyme Immunoassay (EIA)
(384), (291), (215), (132), (101), (59), (48), (9), (6), (6), (4), (2), (1)
Pubmed 5 references available
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Product Details anti-TSC2 Antibody

Target Details TSC2 Application Details Handling References for anti-TSC2 Antibody (ABIN358411) Images
Specificity This antibody detects TSC2 pSer1420.
Purification Affinity purification in a 2-step procedure with the control and phosphorylated peptides. The phospho-specific antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1420 of human TSC2.
Isotype Ig

Target Details TSC2

Product Details anti-TSC2 Antibody Application Details Handling References for anti-TSC2 Antibody (ABIN358411) Images back to top
Antigen
Alternative Name Tuberin / TSC2 (TSC2 Antibody Abstract)
Background Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.Synonyms: TSC4, Tuberous sclerosis 2 protein
Molecular Weight 200749 Da
Gene ID 7249, 9606
UniProt P49815
Pathways RTK Signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-TSC2 Antibody Target Details TSC2 Handling References for anti-TSC2 Antibody (ABIN358411) Images back to top
Application Notes ELISA: 1/1,000. Dot Blot: 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-TSC2 Antibody Target Details TSC2 Application Details References for anti-TSC2 Antibody (ABIN358411) Images back to top
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

References for anti-TSC2 Antibody (ABIN358411)

Product Details anti-TSC2 Antibody Target Details TSC2 Application Details Handling Images back to top
Background publications

Li, Inoki, Guan: "Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity." in: Molecular and cellular biology, Vol. 24, Issue 18, pp. 7965-75, 2004

Karbowniczek, Cash, Cheung, Robertson, Astrinidis, Henske: "Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent." in: The Journal of biological chemistry, Vol. 279, Issue 29, pp. 29930-7, 2004

Corradetti, Inoki, Bardeesy, DePinho, Guan: "Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome." in: Genes & development, Vol. 18, Issue 13, pp. 1533-8, 2004

Birchenall-Roberts, Fu, Bang, Dambach, Resau, Sadowski, Bertolette, Lee, Kim, Ruscetti: "Tuberous sclerosis complex 2 gene product interacts with human SMAD proteins. A molecular link of two tumor suppressor pathways." in: The Journal of biological chemistry, Vol. 279, Issue 24, pp. 25605-13, 2004

Lewis, Thomas, Murphy, Sampson: "Genotype and psychological phenotype in tuberous sclerosis." in: Journal of medical genetics, Vol. 41, Issue 3, pp. 203-7, 2004

Images

Product Details anti-TSC2 Antibody Target Details TSC2 Application Details Handling References for anti-TSC2 Antibody (ABIN358411) back to top
Supplier Images
 image for anti-TSC2 antibody (Tuberous Sclerosis 2) (pSer1420) (ABIN358411) anti-Tuberous Sclerosis 2 (TSC2) (pSer1420) antibody