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anti-Human TSC2 antibody for Flow Cytometry

Recommended TSC2 Antibody (supplied by: Log in to see )

Antigen
Tuberous Sclerosis 2 (TSC2) Antibodies
  • TSC2
  • fc16b02
  • tuberin
  • wu:fc16b02
  • LAM
  • TSC4
  • Nafld
  • Tcs2
  • Rc
  • tuberous sclerosis 2
  • tuberous sclerosis complex 2 (TSC2)
  • TSC2
  • AaeL_AAEL007712
  • tsc2
  • PGTG_00159
  • Tsc2
Epitope
pSer664
42
42
33
28
28
27
24
23
22
22
21
21
21
21
21
21
21
21
21
19
19
18
16
16
15
15
13
13
13
13
11
8
8
6
6
6
6
6
6
6
6
6
6
6
5
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
536
388
211
6
Host
Rabbit
718
25
Clonality
Polyclonal
Conjugate
This TSC2 antibody is un-conjugated
51
51
51
43
42
42
10
10
9
9
9
9
9
9
9
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
387
302
223
148
101
74
63
23
7
7
4
1
1
Supplier
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Catalog No. ABIN2666118
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2666117 FACS Rabbit pSer664 Log in to see Polyclonal

Top referenced anti-TSC2 antibody for Flow Cytometry

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Application / Reactivity Human
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ELISA 253 Antibodies
ELISA (Capture) 1 Antibodies
Enzyme Immunoassay (EIA) 7 Antibodies
Flow Cytometry (FACS) 2 Antibodies
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Immunofluorescence (IF) 60 Antibodies
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Immunohistochemistry (IHC) 149 Antibodies
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Western Blotting (WB) 207 Antibodies

General

Antigen Tuberous Sclerosis 2 (TSC2) Antibodies
Epitope pSer664
(42), (42), (33), (28), (28), (27), (24), (23), (22), (22), (21), (21), (21), (21), (21), (21), (21), (21), (21), (19), (19), (18), (16), (16), (15), (15), (13), (13), (13), (13), (11), (8), (8), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (5), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(536), (388), (211), (6)
Host Rabbit
(718), (25)
Clonality (Clone)
Polyclonal   ( )
Conjugate This TSC2 antibody is un-conjugated
(51), (51), (51), (43), (42), (42), (10), (10), (9), (9), (9), (9), (9), (9), (9), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Flow Cytometry (FACS)
(387), (302), (223), (148), (101), (74), (63), (23), (7), (7), (4), (1), (1)
Pubmed 1 reference available
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Product Details anti-TSC2 Antibody

Target Details TSC2 Application Details Handling References for anti-TSC2 Antibody (ABIN2666118) Images
Purification The antibody was purified by affinity chromatography.
Clone Poly6359

Target Details TSC2

Product Details anti-TSC2 Antibody Application Details Handling References for anti-TSC2 Antibody (ABIN2666118) Images back to top
Antigen
Alternative Name TSC2 (TSC2 Antibody Abstract)
Background Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder that is caused by mutation in either the TSC1 (hamartin) or TSC2 (tuberin) gene. TSC1 and TSC2 proteins form a physical and functional heterodimer in vivo that inhibits ribosomal protein S6 kinase 1 (S6K1) and activates eukaryotic initiation factor 4E-bindingprotein 1 (4E-BP1) by inhibition of the mammalian target of rapamycin (mTOR). TSC2 belongs to small GTPase protein of the Ras superfamily, contain a Rap-GAP domain. Predicted molecular weight 201 kD. Ser664 TSC2 phosphorylation leads to TSC1-TSC2 dissociation and markedly impairs TSC2 ability to inhibit mTOR signaling, cell proliferation, and oncogenic transformation. Erk (extracellular signal-regulated kinase) may contribute to tumorigenesis by phosphorylating TSC2 at specific residues, particularly S664.
Pathways RTK Signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-TSC2 Antibody Target Details TSC2 Handling References for anti-TSC2 Antibody (ABIN2666118) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-TSC2 Antibody Target Details TSC2 Application Details References for anti-TSC2 Antibody (ABIN2666118) Images back to top
Format Liquid
Buffer phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Upon receipt, store frozen at -20°C.

References for anti-TSC2 Antibody (ABIN2666118)

Product Details anti-TSC2 Antibody Target Details TSC2 Application Details Handling Images back to top
Background publications

Inoki, Li, Zhu, Wu, Guan: "TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling." in: Nature cell biology, Vol. 4, Issue 9, pp. 648-57, 2002

Images

Product Details anti-TSC2 Antibody Target Details TSC2 Application Details Handling References for anti-TSC2 Antibody (ABIN2666118) back to top
Supplier Images
Immunofluorescence (IF) image for anti-TSC2 antibody (Tuberous Sclerosis 2) (pSer664) (ABIN2666118) anti-Tuberous Sclerosis 2 (TSC2) (pSer664) antibody
Immunofluorescence (IF) image for anti-TSC2 antibody (Tuberous Sclerosis 2) (pSer664) (ABIN2666118) anti-Tuberous Sclerosis 2 (TSC2) (pSer664) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-TSC2 antibody (Tuberous Sclerosis 2) (pSer664) (ABIN2666118) anti-Tuberous Sclerosis 2 (TSC2) (pSer664) antibody (Image 3)