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anti-Human TSC2 antibody for Flow Cytometry

Recommended TSC2 Antibody (supplied by: Log in to see )

Antigen
Tuberous Sclerosis 2 (TSC2) Antibodies
  • fc16b02
  • LAM
  • Nafld
  • Rc
  • Tcs2
  • TSC2
  • TSC4
  • tuberin
  • wu:fc16b02
Epitope
pSer664
41
40
27
27
27
24
22
22
22
20
20
20
20
20
20
20
20
20
20
18
18
17
16
15
15
15
13
13
13
13
11
8
8
6
6
6
6
6
6
6
6
6
6
5
4
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
505
374
207
6
Host
Rabbit
679
24
Clonality
Polyclonal
Conjugate
This TSC2 antibody is un-conjugated
51
51
51
42
42
42
9
9
9
9
9
9
9
9
9
Application
Flow Cytometry (FACS)
384
291
215
132
101
59
48
9
7
6
4
1
1
Supplier
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Available images

Catalog No. ABIN2666118
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0010666476 ABIN2666117 FACS Rabbit pSer664 Log in to see Polyclonal

Top referenced anti-TSC2 antibody for Flow Cytometry

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General

Antigen Tuberous Sclerosis 2 (TSC2) Antibodies
Epitope pSer664
(41), (40), (27), (27), (27), (24), (22), (22), (22), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (18), (18), (17), (16), (15), (15), (15), (13), (13), (13), (13), (11), (8), (8), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(505), (374), (207), (6)
Host Rabbit
(679), (24)
Clonality (Clone)
Polyclonal   ( )
Conjugate This TSC2 antibody is un-conjugated
(51), (51), (51), (42), (42), (42), (9), (9), (9), (9), (9), (9), (9), (9), (9)
Application Flow Cytometry (FACS)
(384), (291), (215), (132), (101), (59), (48), (9), (7), (6), (4), (1), (1)
Pubmed 1 reference available
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Product Details anti-TSC2 Antibody

Target Details TSC2 Application Details Handling References for anti-TSC2 Antibody (ABIN2666118) Images
Purification The antibody was purified by affinity chromatography.
Clone Poly6359

Target Details TSC2

Product Details anti-TSC2 Antibody Application Details Handling References for anti-TSC2 Antibody (ABIN2666118) Images back to top
Antigen
Alternative Name TSC2 (TSC2 Antibody Abstract)
Background Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder that is caused by mutation in either the TSC1 (hamartin) or TSC2 (tuberin) gene. TSC1 and TSC2 proteins form a physical and functional heterodimer in vivo that inhibits ribosomal protein S6 kinase 1 (S6K1) and activates eukaryotic initiation factor 4E-bindingprotein 1 (4E-BP1) by inhibition of the mammalian target of rapamycin (mTOR). TSC2 belongs to small GTPase protein of the Ras superfamily, contain a Rap-GAP domain. Predicted molecular weight 201 kD. Ser664 TSC2 phosphorylation leads to TSC1-TSC2 dissociation and markedly impairs TSC2 ability to inhibit mTOR signaling, cell proliferation, and oncogenic transformation. Erk (extracellular signal-regulated kinase) may contribute to tumorigenesis by phosphorylating TSC2 at specific residues, particularly S664.
Pathways RTK Signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-TSC2 Antibody Target Details TSC2 Handling References for anti-TSC2 Antibody (ABIN2666118) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-TSC2 Antibody Target Details TSC2 Application Details References for anti-TSC2 Antibody (ABIN2666118) Images back to top
Format Liquid
Buffer phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Upon receipt, store frozen at -20°C.

References for anti-TSC2 Antibody (ABIN2666118)

Product Details anti-TSC2 Antibody Target Details TSC2 Application Details Handling Images back to top
Background publications

Inoki, Li, Zhu, Wu, Guan: "TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling." in: Nature cell biology, Vol. 4, Issue 9, pp. 648-57, 2002

Images

Product Details anti-TSC2 Antibody Target Details TSC2 Application Details Handling References for anti-TSC2 Antibody (ABIN2666118) back to top
Supplier Images
Immunofluorescence (IF) image for anti-TSC2 antibody (Tuberous Sclerosis 2) (pSer664) (ABIN2666118) anti-Tuberous Sclerosis 2 (TSC2) (pSer664) antibody
Immunofluorescence (IF) image for anti-TSC2 antibody (Tuberous Sclerosis 2) (pSer664) (ABIN2666118) anti-Tuberous Sclerosis 2 (TSC2) (pSer664) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-TSC2 antibody (Tuberous Sclerosis 2) (pSer664) (ABIN2666118) anti-Tuberous Sclerosis 2 (TSC2) (pSer664) antibody (Image 3)