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Metallocarboxypeptidase that mediates tubulin deglutamylation. Additionally we are shipping ATP/GTP Binding Protein-Like 5 Proteins (4) and many more products for this protein.
Showing 10 out of 60 products:
Human Polyclonal AGBL5 Primary Antibody for ICC, IF - ABIN4278659
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
Mouse (Murine) Polyclonal AGBL5 Primary Antibody for ELISA, WB - ABIN4278660
Rogowski, van Dijk, Magiera, Bosc, Deloulme, Bosson, Peris, Gold, Lacroix, Bosch Grau, Bec, Larroque, Desagher, Holzer, Andrieux, Moutin, Janke: A family of protein-deglutamylating enzymes associated with neurodegeneration. in Cell 2010
Ccp5 is the principal tubulin deglutamylase that maintains functional levels of cilia tubulin glutamylation.
These data suggest that CCP1 and CCP5 play important roles in developmental processes, particularly the development and functioning of cilia.
WES identified a homozygous frameshift mutation (c.1787_1788del, p.His596Argfs*47) in AGBL5, associated with nonsyndromic RP.
Homology models indicated destabilization of AGBL5 due to the p.Arg281Cys change.
Our study expands the clinical and allelic spectrum of known Retinal dystrophies genes, and reveals AGBL5, CDH16, and DNAJC17 as novel disease candidates.
The identification of AGBL5 and TTLL5, a previously described RP-associated gene encoding the tubulin tyrosine ligase-like family, member 5 protein, highlights the importance of poly- and deglutamylation in retinal homeostasis.
Due to the characteristic Retinitis Pigmentosa phenotype in patients carrying the AGBL5 missense mutation we suggest this gene as a candidate for a new form of autosomal recessively inherited RP
Nna1 and CCP5 do not work coordinately in the same pathway in either the nervous system or spermatogenesis.
CCP5 functions as a dual-functional deglutamylase cleaving both alpha- and gamma-linked glutamate from tubulin.
Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post- translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains (By similarity).
ATP/GTP-binding protein-like 5
, cytosolic carboxypeptidase-like protein 5
, ATP/GTP binding protein-like 5
, cytosolic carboxypeptidase-like protein 5-like
, carboxypeptidase 5, cytosolic
, Cytosolic carboxypeptidase-like protein 5