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CTDP1 encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Additionally we are shipping CTDP1 Antibodies (40) and CTDP1 Kits (2) and many more products for this protein.
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Study identifies CTDP1 as an autoantigen specific for Behcet Disease.
results demonstrated that CTDP1 was upregulated in human lung cancer tissues. In addition, it implied that CTDP1 played an important role in cell proliferation and may be a useful therapeutic target in human lung cancer.
Data propose that Fcp1 has a crucial role in the liaison between dephosphorylation and ubiquitination that drives mitosis exit.
although FCP1 is intrinsically disordered, the above 16 residues composing the RAP74 (show GTF2F1 Proteins) binding surface form nascent alpha-helical structure in the unbound state.
FCP1 augments tat (show TAT Proteins) transactivation of the HIV-1 long-terminal repeat
FCP1 is important for transcription elongation along with TFIIF (show GTF2F1 Proteins)
FCP1 binds to a groove of RAP74 (show GTF2F1 Proteins) between alpha-helices H2 and H3, without affecting the secondary structure of RAP74 (show GTF2F1 Proteins) C-terminal domain; FCP1 binds also to a groove of TFIIB (show GTF2B Proteins) core domain beween alpha helices D1 and E1 in the first cyclin (show PCNA Proteins) repeat.
FCP1 kinase from HeLa cells is phosphorylated and affects transcription elongation
cocrystal structure of the winged-helix domain of human RNA polymerase II-associating protein 74 bound to the alpha-helical C terminus of human FCP1
Congenital cataracts facial dysmorphism neuropathy is caused by a single-nucleotide substitution in an antisense Alu element in intron 6 of CTDP1, resulting in a rare mechanism of aberrant splicing and an Alu insertion in the processed mRNA
This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
RNA polymerase II subunit A C-terminal domain phosphatase
, CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
, RNA polymerase II subunit A C-terminal domain phosphatase-like
, CTD of POLR2A, phosphatase of, subunit 1
, TFIIF-associating CTD phosphatase 1
, serine phosphatase FCP1a
, transcription factor IIF-associating CTD phosphatase 1
, CTD (carboxy-terminal domina, RNA polymerase II, polypeptide A) phosphatase, subunit 1
, TFIIF-associating CTD phosphatase