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CTNND2 encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. Additionally we are shipping Catenin (Cadherin-Associated Protein), delta 2 (Neural Plakophilin-Related Arm-Repeat Protein Antibodies (53) and many more products for this protein.
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delta-Catenin Regulates Spine Architecture via Cadherin and PDZ-dependent Interactions.
Results conclude that the introduction of CTNND2 gene variation is an important milestone in prostate cancer metabolic adaptation.
Delta-catenin occurs in mouse brain dendrites along with PSD-95 (show DLG4 Proteins) in postsynaptic scaffolds. It forms stable complexes with glutamate (show GRIN1 Proteins) receptors, suggesting a link between delta-catenin and glutamatergic synaptic transmission during neuronal development.
PS-1 (show PSEN1 Proteins) can affect delta-catenin-induced morphogenesis possibly through the regulation of its processing and stability.
conditional targeting of p120 catenin (show CTNND1 Proteins) in mice leads to progressive development of skin neoplasias associated with intrinsic NF-kappaB (show NFKB1 Proteins) activation.
Acute knockdown of delta-catenin leads to increases in spine and synapse density in hippocampal neurons during development.
We propose CTNND2 as the causal gene infamilial cortical myoclonic tremor and epilepsy-3
At the molecular level, CTNND2 is at the crossroad with interactions to such signaling pathways of Wnt and Rho family small GTPases in the Ras superfamily, which are known to drive human disease pathogenesis.
Our data suggested that genetic variants in GRM6 (show GRM6 Proteins) are associated with high myopia. The mechanism of GRM6 (show GRM6 Proteins) in the development of high myopia need to be further investigated.
Multigenerational autosomal dominant inheritance of 5p chromosomal deletions resulting in Cri-du-Chat Syndrome with SEMA5A, CTNND2, and ICE1 deficiencies has been described.
the effect of CTNND2 polymorphisms on normal variability and identified a polymorphism (rs2561622) with significant effect on phonological ability and white matter volume in the left frontal lobe, was investigated.
Study describes two Ion-syndromic intellectual disability cases, positive for the presence of a small copy number variants, intragenic CTNND2 gene deletion.
co-expression of Delta-catenin and RhoA (show RHOA Proteins) was significantly associated with histological type, differentiation, pTNM stage, lymphatic metastasis and a poor prognosis in non-small cell lung cancer
our results suggest that delta-catenin acts as an oncoprotein when overexpressed in esophageal squamous cell carcinoma
SNPs in CTNND2 showed an increased signal for schizophrenia and major depressive disorder, but not for bipolar disorder. The association between CTNND2 and anxiety was not strong enough in current generation of human genome-wide analyses.
This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome.
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
, catenin delta-2-like
, catenin delta 2
, catenin delta-2
, neural plakophilin-related arm-repeat protein
, T-cell delta-catenin
, catenin (cadherin-associated protein), delta 2