anti-Ceramide Kinase (CERK) Antibodies

CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Additionally we are shipping CERK Kits (9) and CERK Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CERK 223753 Q8K4Q7
CERK 300129  
CERK 64781 Q8TCT0
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Top anti-CERK Antibodies at antibodies-online.com

Showing 10 out of 85 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Dog Rabbit Un-conjugated WB Host: Rabbit Target Name: CERK Sample Type: 721_B Whole Cell lysates Antibody Dilution: 1.0ug/ml 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with CERK antibody ABIN213483 at 20 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with CERK antibody ABIN213431 at 20 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-CERK antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated WB Antibody is used in Western blot to detect CERK in mouse heart tissue lysate (Lane 1) and A2058 cell lysate (Lane 2). 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated EIA, WB The anti-CERK Pab is used in Western blot to detect CERK in mouse heart tissue lysate (Lane 1) and A2058 cell lysate (Lane 2). 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Anti-Ceramide Kinase / CERK antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50. 200 μL 11 to 14 Days
$484.00
Details
Human Mouse Un-conjugated WB Western Blot analysis of CERK expression in transfected 293T cell line by CERK MaxPab polyclonal antibody.Lane 1: CERK transfected lysate(22.11 KDa).Lane 2: Non-transfected lysate. 50 μL 11 to 12 Days
$440.00
Details
Gibbon Rabbit Un-conjugated IHC 0.05 mg 2 to 3 Days
$618.75
Details
Horse Rabbit Un-conjugated WB   100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p) 50 μg 12 to 14 Days
$686.14
Details

Top referenced anti-CERK Antibodies

  1. Human Polyclonal CERK Primary Antibody for ICC, IF - ABIN251388 : Dória, Ribeiro, Wang, Cotrim, Domingues, Williams, Domingues, Helguero: Fatty acid and phospholipid biosynthetic pathways are regulated throughout mammary epithelial cell differentiation and correlate to breast cancer survival. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 (PubMed)

  2. Polyclonal CERK Primary Antibody for WB - ABIN540755 : Wijesinghe, Massiello, Subramanian, Szulc, Bielawska, Chalfant: Substrate specificity of human ceramide kinase. in Journal of lipid research 2005 (PubMed)

  3. Human Polyclonal CERK Primary Antibody for ELISA, WB - ABIN545572 : Hinkovska-Galcheva, Clark, VanWay, Huang, Hiraoka, Abe, Borofsky, Kunkel, Shanley, Shayman, Lanni, Petty, Boxer: Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells. in Journal of lipid research 2008 (PubMed)

More Antibodies against CERK Interaction Partners

Mouse (Murine) Ceramide Kinase (CERK) interaction partners

  1. the data presented in this work suggest that exogenous C1P may balance adipogenesis, and that targeting CerK may be a novel way for potential applications in the treatment of obesity or other inflammation-associated diseases

  2. results suggest that intracellular ceramide kinase is required for the migration of bone marrow-derived mesenchymal stem cells, and the roles of the intrinsic ceramide kinase in the migration are associated with N-cadherin regulation

  3. The depletion of CerK enhances the pathology of colitis and lethal responses in DSS-treated mice.

  4. these studies demonstrate a novel requirement for the CERK-derived C1P in the proper healing response of wounds.

  5. there are significant differences in eicosanoid levels in ex vivo CERK(-/-) cells compared with wild-type counterparts, but the effect of the genetic ablation of CERK on eicosanoid synthesis and the serum levels of C1P was not apparent in vivo

  6. role of ceramide kinase in obesity and insulin resistance

  7. Results indicate that C1P produced by CERK has a negative effect on the processing/secretion of TNFalpha via modulation of TACE activity.

  8. role of CerK on the activation of mast cells

  9. The mechanism of ceramide-mediated inhibition is likely to involve conversion of ceramide to ceramide 1-phosphate by CERK.

  10. LPS inhibits the transcriptional activity of the Cerk proximal promoter;transcriptional repression of Cerk by LPS is not a primary consequence of LPS-induced cell cycle blockade.

  11. Findings suggest that CerK is not necessary for survival at an individual level, but might be involved in higher brain function related to emotion.

  12. CerK is essential to ceramide 1-phosphate formation via phosphorylation of Cer

  13. Ceramide kinase is a key regulator of ceramide 1-phosphate, dihydroceramide and ceramide levels, with important implications for neutrophil homeostasis and innate immunity regulation.

Human Ceramide Kinase (CERK) interaction partners

  1. an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5

  2. Our study expands the genotypic spectra of CERKL variants, providing insights into the relevant pathogenesis of RP/CRD

  3. results suggest that intracellular ceramide kinase is required for the migration of bone marrow-derived mesenchymal stem cells, and the roles of the intrinsic ceramide kinase in the migration are associated with N-cadherin regulation

  4. our findings identify a functional role for Cerk in breast cancer recurrence and suggest the clinical utility of agents targeted against this prosurvival pathway.

  5. Data suggest that inhibition of ceramide kinase (CerK) [by specific gene silencing or pharmacological inhibition] drastically reduced cell proliferation in a neuroblastoma cell line.

  6. TNF-alpha exposure of human SH-SY5Y neuroblastoma caused a profound increase in CERK activity.

  7. Expression of hCERK enhanced ceramide-1-phosphate formation and release of arachidonic acid in Ca(2+) ionophore-stimulated cells.

  8. We have identified a differential role for ceramide kinase in mast-cell activation

  9. Molecular cloning and functional characterization

  10. ceramide kinase and its product, C-1-P, have roles in arachidonic acid release and production of eicosanoids

  11. CERK translocates during activation from the cytosol to a lipid raft fraction

  12. Pleckstrin homology domain of CERK is not only indispensable for its activity but also act as a regulator of CERK activity.

  13. sphingoid chain was also required for substrate recognition by CERK

  14. Recombinant CERK was analyzed with regard to dependence on divalent cations, to substrate delivery, specificity, and stereoselectivity. CERK associated with the plasma membrane in CHO cells, which is mediated by the N-terminal putative pleckstrin domain.

  15. CERK-pleckstrin homology domain plays a crucial role in plasma membrane targeting through its binding to phosphatidylinositol 4,5-bisphosphate and subsequent induction of ceramide-1-phosphate production in the vicinity of the membrane.

  16. These results suggest that ceramide kinase determines the balance between pro-apoptotic ceramide and anti-apoptotic C1P to regulate cell fate, reminiscent of its function in plants.

  17. Results demonstrate that CERK localizes to areas of eicosanoid synthesis and uses a ceramide "pool" transported in an active manner via CERT.

  18. HL-60 cells are useful for studying CerK functions in leukocyte differentiation, and they also suggest that CerK might have an important role in such differentiation.

  19. higher Ca2+ signal observed in hCERK transfected cells as well as the fact that CERK colocalized with EIgG during phagocytosis support hypothesis that Ca2+ signaling is an important factor for increasing phagocytosis and is regulated by CERK

  20. identification of a cluster of cysteines, C(347)XXXC(351)XXC(354), essential for CerK function

CERK Antigen Profile

Protein Summary

CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006

Gene names and symbols associated with anti-Ceramide Kinase (CERK) Antibodies

  • ceramide kinase (Cerk) antibody
  • ceramide kinase (CERK) antibody
  • ceramide kinase (cerk) antibody
  • ceramide kinase S homeolog (cerk.S) antibody
  • ceramide kinase (CpipJ_CPIJ003342) antibody
  • ceramide kinase (LOAG_11245) antibody
  • Ceramide kinase (Cerk) antibody
  • ceramide kinase (LOC5579301) antibody
  • Ceramide kinase (Bm1_50005) antibody
  • AI848610 antibody
  • CERK antibody
  • CG16708 antibody
  • D330016D08Rik antibody
  • dA59H18.2 antibody
  • dA59H18.3 antibody
  • dcerk antibody
  • Dmel\\CG16708 antibody
  • hCERK antibody
  • LK4 antibody
  • MGC81777 antibody
  • mKIAA1646 antibody
  • si:ch211-162i19.1 antibody

Protein level used designations for anti-Ceramide Kinase (CERK) Antibodies

acylsphingosine kinase , mCERK , lipid kinase 4 , lipid kinase LK4 , ceramide kinase , CG16708-PA , CG16708-PB , Cerk-PA , Cerk-PB , Ceramide kinase

GENE ID SPECIES
223753 Mus musculus
300129 Rattus norvegicus
64781 Homo sapiens
474464 Canis lupus familiaris
100053604 Equus caballus
458921 Pan troglodytes
425523 Gallus gallus
558496 Danio rerio
444466 Xenopus laevis
6034795 Culex quinquefasciatus
9948698 Loa loa
40640 Drosophila melanogaster
5579301 Aedes aegypti
6104885 Brugia malayi
100336737 Bos taurus
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