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Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. Additionally we are shipping Chitinase 3-Like 1 (Cartilage Glycoprotein-39) Antibodies (105) and Chitinase 3-Like 1 (Cartilage Glycoprotein-39) Kits (72) and many more products for this protein.
Showing 10 out of 24 products:
Human CHI3L1 Protein expressed in HEK-293 Cells - ABIN2713970
Cantó, Tintoré, Villar, Costa, Nurtdinov, Álvarez-Cermeño, Arrambide, Reverter, Deisenhammer, Hegen, Khademi, Olsson, Tumani, Rodríguez-Martín, Piehl, Bartos, Zimova, Kotoucova, Kuhle, Kappos et al.: Chitinase 3-like 1: prognostic biomarker in clinically isolated syndromes. ... in Brain : a journal of neurology 2015
The mouse model was used to validate the function of CHI3L1 in cancer metastasis in vivo
CHI3L1-mediated cell proliferation/survival involves partial downregulation of the pro-apoptotic S100A9 (show S100A9 Proteins) protein that is highly expressed during the acute phase of colitis, by binding to the S100A9 (show S100A9 Proteins) receptor, RAGE (show AGER Proteins) (Receptor for Advanced Glycation End products).
IL-18 (show IL18 Proteins) is a potent stimulator of Chi3l1 and that Chi3l1 is an important mediator of IL-18 (show IL18 Proteins)-induced inflammatory, fibrotic, alveolar remodeling, and cytotoxic responses.
CHI3L1 is induced during fungal infection, and it regulated antifungal innate immune responses in the cornea.
Astrocytic expression of chitinase 3-like protein 1 limits the extent of both astrocytic and microglial/macrophage facets of neuroinflammation.
Results do not support a role of BRP (show GDF5 Proteins)-39 in the pathogenesis of experimental autoimmune encephalitis.
CHI3L1 was increased in plasma and brain tissue in experimental cerebral malaria, but targeted Chi3l1 deletion did not alter cytokine production or survival in this model.
mechanism of BRP (show GDF5 Proteins)-39 in bleomycin-induced pulmonary fibrosis
Sem7a and its receptors regulate Chi3l1 in pulmonary melanoma metastasis
Data show that IL-1 (show IL1A Proteins)-induced transcriptin factor RelB (show RELB Proteins)/NF-kappa B p50 (show NFKB1 Proteins) Subunit complex formation was further promoted by oncostatin M (show OSM Proteins) and that these complexes directly bound to the secreted protein cartilage glycoprotein 39 (YKL-40) promoter.
The level of serum YKL-40 is a significant and independent biomarker to predict the clinical outcome in large-artery atherosclerotic stroke.
TrkB (show NTRK2 Proteins)-containing exosomes play a key role in the control of glioblastoma progression and aggressiveness, as seen in a model of YKL-40-inactivated glioblastoma cells
findings suggest that these pulmonary markers could be useful to assess CAP severity and, especially YKL-40 and CCL18 (show CCL18 Proteins) by helping predict CAP caused by atypical pathogens
The present meta-analysis indicate that elevated YKL-40 expression is associated with a poor prognosis in breast cancer patients. YKL-40 may serve as a promising predictive biomarker of prognosis of breast cancer
YKL-40 induces IL-18 production in osteoblasts and thereby stimulates angiogenesis of endothelial progenitor cells through the suppression of miR-590-3p via the focal adhesion kinase (FAK)/PI3K/Akt signaling pathway.
YKL-40 levels showed a positive correlation with blood neutrophil counts but no consistent relationships with clinical characteristics of relevance to continuous wheeze in preschool children
Study suggests that YKL-40 is associated with hypertension incidence only among men.
In HCT donors with YKL-40 plasma concentrations, a trend toward increased grade II-IV acute GvHD in recipients was observed with no significant associations with overall survival, treatment-related mortality or relapse
Review of evidence for the role of YKL-40 in the diagnosis, prognosis and cause of cardiovascular and alcoholic liver disease.
the level of CHI3L1 protein in the sera of patients with gastric or breast cancer was significantly elevated compared with those of healthy donors. M2 macrophage-secreted CHI3L1 promoted the metastasis of gastric and breast cancer cells in vitro and in vivo
chitinase-like lectin, YKL-40, binds specifically to type I collagen and modulates the rate of type I collagen fibril formation
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling.
, cartilage glycoprotein 39
, chitinase-3-like protein 1
, 39 kDa synovial protein
, 38 kDa heparin-binding glycoprotein
, signal-processing protein
, 39 kDa whey protein
, 40 kDa secretory signalling glycoprotein
, cartilage glycoprotein-39
, chitinase-like protein 1
, signal processing protein
, chitinase 3-like 1 protein
, mammary gland protein 40