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CNTNAP2 encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. Additionally we are shipping CNTNAP2 Antibodies (76) and CNTNAP2 Proteins (6) and many more products for this protein.
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Subjects with greater left dorsolateral prefrontal cortex (DLPFC) surface area had better cognitive performance. Importantly, the left DLPFC surface area mediated the association between the CNTNAP2 rs4726946 genotype and cognitive performance. This study provides the first evidence for associations among the CNTNAP2 gene, left DLPFC structure, and cognitive control.
associations of a common CNTNAP2 polymorphism (rs7794745) with variation in grey matter in a region in the dorsal visual stream
Bi-allelic aberrations (mutations and copy number variants) in CNTNAP2 in eight individuals with intellectual disability and epilepsy were reported.
Older age is a strong predictor of CNS involvement in patients seropositive for CASPR2-IgG or LGI1 (show LGI1 ELISA Kits)-IgG. Pain, peripheral manifestations, and stereotypic paroxysmal dizziness spells are common with LGI1 (show LGI1 ELISA Kits)-IgG.
Caspr2 antibodies associate with a treatable disorder that predominantly affects elderly men. The resulting syndrome may vary among patients but it usually includes a set of well-established symptoms.
The molecular shape and dimensions of CNTNAP2 place constraints on how CNTNAP2 integrates in the cleft of axo (show MARCH7 ELISA Kits)-glial and neuronal contact sites and how it functions as an organizing and adhesive molecule.
A significant association was found between rs7794745 CNTNAP2 gene polymorphism and autism in an Iranian population.
rs7794745 in the CNTNAP2 gene was associated with autistic spectrum disorder in Brazilian patients.
we could not detect any significant association with the CNTNAP2 gene and high functioning autism
CNTNAP2 is transcriptionally regulated by FOXP2 (show FOXP2 ELISA Kits).
Cntnap2 KO rats exhibited severe motor seizures, hyperactivity, and increased consolidation of wakefulness and REM (show REM1 ELISA Kits) sleep. By contrast, Cntnap2 KO mice demonstrated absence seizure-like events, hypoactivity, and wake fragmentation.
After middle cerebral artery occlusion mice demonstrate profoundly impaired socially evoked USVs. In addition, there is suppression of the language-associated transcription factor,contactin-associated protein 2 (Cntnap2).
Olfaction-based behavioral tests revealed that mice lacking Caspr2 exhibit abnormal response to sensory stimuli and lack preference for novel odors.
Mice with the Cntnap2 genetic mutation showed a dissociation of auditory-processing abilities
Study reports behavioral characterization of mouse models of autism with null mutation in Cntnap2 gene. It shows hyperactivity, mild gait phenotype and reduced vocalizations among others.
new dendritic spines in mice lacking CNTNAP2 were formed at normal rates, but failed to stabilize. Notably, rates of spine elimination were unaltered, suggesting a specific role for CNTNAP2 in stabilizing new synaptic circuitry
Cntnap2 deletion selectively impairs perisomatic hippocampal inhibition while sparing excitation provide additional support for synaptic dysfunction as a common mechanism underlying autism spectrum disorders
The CASPR2/MUPP1 (show MPDZ ELISA Kits) receptor complex co-localized with GPR37 (show GPR37 ELISA Kits) in hippocampal neurons.
Interaction proteomics revealed the interactors of Caspr2, including CNTN2, KCNAs, members of the ADAM family (ADAM22, ADAM23 and ADAM11), members of LGI family and MAGUKs (DLGs and MPPs).
CNTNAP2 has a role in the correct trafficking of GluA1 (show GRIA1 ELISA Kits) AMPA (show GRIA3 ELISA Kits)-type glutamate (show GRIN1 ELISA Kits) receptors
This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.
cell recognition molecule Caspr2
, contactin-associated protein-like 2
, homolog of Drosophila neurexin IV
, contactin associated protein-like 2
, novel protein similar to H.sapiens contactin associated protein
, contactin associated protein 2
, contactin-associated protein-like 2-like