anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) Antibodies

CTLA4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. Additionally we are shipping CTLA4 Proteins (82) and CTLA4 Kits (51) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CTLA4 12477 P09793
CTLA4 1493 P16410
CTLA4 63835  
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Top anti-CTLA4 Antibodies at antibodies-online.com

Showing 10 out of 455 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Armenian Hamster Un-conjugated FACS, IP   0.5 mg Log in to see 6 to 8 Days
$327.18
Details
Mouse Armenian Hamster Un-conjugated BR, FACS, IP   0.5 mg Log in to see 6 to 8 Days
$333.96
Details
Human Mouse Un-conjugated EIA, Func, FACS, IHC (fro)   0.2 mg Log in to see 6 to 8 Days
$863.50
Details
Human Mouse Biotin FACS   100 Tests Log in to see 6 to 8 Days
$363.09
Details
Human Mouse Un-conjugated IHC (f), ICC, FACS, IP   0.1 mg Log in to see 5 to 7 Days
$253.00
Details
Mouse Rat Un-conjugated CyTOF, FACS, Neut, WB CTLA-4 Inhibition of B7-1/CD80-induced IL-2 Secretion and Neutralization by Mouse CTLA-4 Antibody. Recombinant Mouse CTLA-4 Fc Chimera. 100 μg Log in to see 8 to 9 Days
$328.90
Details
Mouse Golden Syrian Hamster Un-conjugated BR, FACS   0.5 mg Log in to see 6 to 8 Days
$544.05
Details
Mouse Rat Fluorescein FACS 100 Tests Log in to see 8 to 9 Days
$281.75
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin fixed and paraffin embedded human prostate carcinoma reacted with CD152 / CTLA4 Antibody (N-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. Western blot analysis of CD152 / CTLA4 Antibody (N-term) in WiDr cell line lysates (35ug/lane). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated IHC (fro), FACS, IF, IHC (p)   1 mL Log in to see 6 to 8 Days
$191.57
Details

CTLA4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-CTLA4 Antibodies

  1. Mouse (Murine) Monoclonal CTLA4 Primary Antibody for BR, FACS - ABIN1176976 : Kearney, Walunas, Karr, Morton, Loh, Bluestone, Jenkins: Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. in Journal of immunology (Baltimore, Md. : 1950) 1995 (PubMed)
    Show all 18 Pubmed References

  2. Mouse (Murine) Monoclonal CTLA4 Primary Antibody for FACS, IP - ABIN2688989 : Harper, Balzano, Rouvier, Mattéi, Luciani, Golstein: CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location. in Journal of immunology (Baltimore, Md. : 1950) 1991 (PubMed)
    Show all 17 Pubmed References

  3. Mouse (Murine) Monoclonal CTLA4 Primary Antibody for BR, FACS - ABIN1176977 : Alegre, Noel, Eisfelder, Chuang, Clark, Reiner, Thompson: Regulation of surface and intracellular expression of CTLA4 on mouse T cells. in Journal of immunology (Baltimore, Md. : 1950) 1996 (PubMed)
    Show all 15 Pubmed References

  4. Human Monoclonal CTLA4 Primary Antibody for IHC (f), ICC - ABIN1981896 : Steiner, Moosig, Csernok, Selleng, Gross, Fleischer, Bröker: Increased expression of CTLA-4 (CD152) by T and B lymphocytes in Wegener's granulomatosis. in Clinical and experimental immunology 2001 (PubMed)
    Show all 4 Pubmed References

  5. Human Monoclonal CTLA4 Primary Antibody for FACS - ABIN2688990 : Guesdon, Ternynck, Avrameas: The use of avidin-biotin interaction in immunoenzymatic techniques. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1979 (PubMed)
    Show all 4 Pubmed References

  6. Human Monoclonal CTLA4 Primary Antibody for IHC (f), ICC - ABIN2749015 : Chin, Chu, Chen, Hsu, Weng, Chu: Site-directed in vitro immunization leads to a complete human monoclonal IgG4 lambda that binds specifically to the CDR2 region of CTLA-4 (CD152) without interfering the engagement of natural ligands. in BMC biotechnology 2007 (PubMed)
    Show all 4 Pubmed References

  7. Human Monoclonal CTLA4 Primary Antibody for Func, FACS - ABIN1177323 : Kuiper, Brouwer, Linsley, van Lier: Activated T cells can induce high levels of CTLA-4 expression on B cells. in Journal of immunology (Baltimore, Md. : 1950) 1995 (PubMed)
    Show all 3 Pubmed References

  8. Human Monoclonal CTLA4 Primary Antibody for Func, FACS - ABIN610404 : Behrens, Vakaet, Friis, Winterhager, Van Roy, Mareel, Birchmeier et al.: Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC ... in The Journal of cell biology 1993 (PubMed)
    Show all 4 Pubmed References

  9. Human Monoclonal CTLA4 Primary Antibody for Func, FACS - ABIN610405 : Chitaev, Troyanovsky: Adhesive but not lateral E-cadherin complexes require calcium and catenins for their formation. in The Journal of cell biology 1998 (PubMed)
    Show all 4 Pubmed References

  10. Human Monoclonal CTLA4 Primary Antibody for IHC (f), ICC - ABIN1981873 : Steiner, Waase, Rau, Dietrich, Fleischer, Bröker: Enhanced expression of CTLA-4 (CD152) on CD4+ T cells in HIV infection. in Clinical and experimental immunology 1999 (PubMed)
    Show all 3 Pubmed References

More Antibodies against CTLA4 Interaction Partners

Rhesus Monkey Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) interaction partners

  1. Data show that CTLA-4(+)PD-1 (show PDCD1 Antibodies)(-) memory CD4 (show CD4 Antibodies)(+) T cells, which share phenotypic markers with regulatory T cells, were enriched in SIV DNA in blood, lymph nodes (LN), spleen, and gut (show GUSB Antibodies), and contained replication-competent and infectious virus.

Mouse (Murine) Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) interaction partners

  1. The potential of the CTLA4 and G250 co-expression DNA vaccine.

  2. Tregs were observed to regulate CD4 (show CD4 Antibodies)(+), but not CD8 (show CD8A Antibodies)(+), T cell infiltration into tumors through a CTLA-4/CD80 (show CD80 Antibodies) dependent mechanism. Disrupting CTLA-4 interaction with CD80 (show CD80 Antibodies) was sufficient to induce CD4 (show CD4 Antibodies) T cell infiltration into tumors.

  3. These results suggest that CD44 (show CD44 Antibodies)(+)CD117(+) T cells are stem cells and a specific T-cell phenotype that initially develops in the thymus, but they do not progress through DN3 and DN4 stages, lack a DP stage, and potently suppress T-cell proliferation and modulate the CTLA-4 pathway.

  4. data suggest that increased expression of checkpoint blockade molecules PD-1 (show PDCD1 Antibodies) and CTLA-4 on donor T cells is not sufficient to prevent GvHD, and that cooperation between checkpoint blockade signaling by host cells and donor Tregs is necessary to limit GvHD in allo-HSCT recipients

  5. Treg cells expand in both humans and mice in blood-stage malaria and interfere with conventional T helper cell responses and follicular T helper (TFH)-B cell interactions in germinal centers. Mechanistically, Treg cells function in a critical temporal window to impede protective immunity through cytotoxic-T-lymphocyte-associated protein-4 (CTLA-4).

  6. CTLA-4 expressed by FOXP3 (show FOXP3 Antibodies)(+) regulatory T cells prevents inflammatory tissue attack and not T-cell priming in arthritis.

  7. results are consistent with a complex pathway in which CD28 (show CD28 Antibodies) is the primary driver of Treg proliferation and CTLA-4 functions as the main brake but is also dependent on TCR signals and interactions with CD80 (show CD80 Antibodies)/CD86 (show CD86 Antibodies)

  8. CTLA-4(+) microvesicles can competitively bind B7 costimulatory molecules on bystander dendritic cells, resulting in downregulation of B7 surface expression.

  9. this study shows that miR (show MLXIP Antibodies)-155 is modulated by a major dust mite allergen, Dermatophagoides farinae (Df1), and increases CD4 (show CD4 Antibodies)+ T cell proliferation through the downregulation of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expression

  10. CTLA-4 regulates atherosclerosis by suppressing proatherogenic immune responses.

Human Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) interaction partners

  1. Taken together, we found that Id3 (show ID3 Antibodies)+ and CTLA-4+ endometrial cells were significantly higher in women with repeated implantation failure and recurrent miscarriage, suggesting the negative roles of these angiogenesis and immune tolerance markers involving in regulating endometrium receptivity.

  2. Suggest that genetic polymorphisms of CTLA-4 function as sex-dependent risk factors for development of acute rejection in an Iranian kidney transplant population.

  3. A phase Ib study of dasatinib plus ipilimumab in patients with gastrointestinal stromal tumor (GIST) and other sarcomas was performed on the basis of preclinical data demonstrating that combined KIT and CTLA-4 blockade is synergistic.

  4. The data we presented here showed that CTLA-4 was highly expressed in regulatory T cells and PD-1 (show PDCD1 Antibodies) decreased in CD8 (show CD8A Antibodies)+ T cells in peripheral blood of SCLC patients, suggesting their unique mechanisms involved in immune regulation.

  5. Significant differences in the CpG-methylation patterns between tumor tissues and matched controls were observed for CTLA4 showing a decreased methylation of this gene in non-small cell lung cancer patients. Expression studies confirmed that hypomethylation also resulted in increased expression of CTLA4.

  6. In children with idiopathic nephrotic syndrome (INS (show INS Antibodies)), serum CTLA-4 concentration significantly increased at remission compared with onset. Furthermore, a positive significant correlation was observed between Treg number and serum CTLA-4 level. This suggests that Treg and CTLA-4 are involved in the induction of remission in INS (show INS Antibodies).

  7. The Genetic analysis of this study revealed that the very early onset JMG had a more prominent genetic predisposition in an immunomodulating gene (CTLA4).

  8. Association between CTLA4 G allele/GG genotype and acute rejection risk in renal transplantation was found in this meta-analysis (G allele: OR=1.21, 95% CI: 1.03-1.44, P=.02; GG genotype: OR=1.37, 95% CI: 1.10-1.69, P=.004). However, the AA genotype was not associated with acute rejection risk in renal transplantation.

  9. CTLA-4 polymorphisms are significant risk factors for transplant-related mortality and survival in children undergoing allogeneic hematopoietic stem cell transplantation and should be evaluated in further trials.

  10. Review/Meta-analysis: CTLA4 +49A/G polymorphisms increased the risk of type 1 diabetes mellitus in children, and can be considered to be a genetic marker for T1D in children.

Pig (Porcine) Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) interaction partners

  1. Suggest a truncated diphtheria toxin based recombinant porcine CTLA-4 fusion toxin as a novel approach for in vivo depletion of CD80 (show CD80 Antibodies)-positive cells.

Cow (Bovine) Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) interaction partners

  1. The surface expression of CTLA-4 was increased in subclinical stages of paratuberculosis infection while levels of ZAP-70 (show ZAP70 Antibodies) were decreased in CD4 (show CD4 Antibodies)+ T cells of both subclinical and clinical animals, indicating a change in T cell phenotype with disease state.

  2. These results suggested that the expression level of CTLA-4 in CD4 (show CD4 Antibodies)-positive T cells has a potentially immunosuppressive function in bovine leukemia infection.

  3. Experimental infection with bovine viral diarrhea virus did not provide evidence ofTreg activation based on expression of FoxP3 (show FOXP3 Antibodies) and CTLA4.

CTLA4 Antigen Profile

Protein Summary

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

Gene names and symbols associated with CTLA4

  • cytotoxic T-lymphocyte associated protein 4 (CTLA4) antibody
  • cytotoxic T-lymphocyte-associated protein 4 (Ctla4) antibody
  • CD antibody
  • Cd152 antibody
  • CELIAC3 antibody
  • Ctla-4 antibody
  • CTLA4 antibody
  • GRD4 antibody
  • GSE antibody
  • IDDM12 antibody
  • Ly-56 antibody
  • sCTLA4 antibody

Protein level used designations for CTLA4

cytotoxic T-lymphocyte-associated protein 4 precursor , CD152 protein , cytotoxic T-lymphocyte protein 4 , cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM , cytotoxic T-lymphocyte-associated protein 4 , costimulatory molecule B7 receptor , cytotoxic T lymphocyte-associated antigen 4 , CD152 antigen , cytotoxic T-lymphocyte-associated antigen 4 , CD152 isoform , celiac disease 3 , cytotoxic T lymphocyte associated antigen 4 short spliced form , cytotoxic T-lymphocyte antigen 4 , cytotoxic T-lymphocyte-associated serine esterase-4 , ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4 , soluble form , transmembrane form , CTLA-4 , cytotoxic T lymphocyte-associated protein 4 , costimulatory molecule B7 receptor CD152

GENE ID SPECIES
443040 Ovis aries
705673 Macaca mulatta
100222727 Taeniopygia guttata
424106 Gallus gallus
470619 Pan troglodytes
493743 Felis catus
100126716 Papio anubis
12477 Mus musculus
1493 Homo sapiens
63835 Rattus norvegicus
100009412 Oryctolagus cuniculus
397286 Sus scrofa
403696 Canis lupus familiaris
281732 Bos taurus
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