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DHX58 Proteins

(DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))

Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.

recommended

DHX58 Protein (AA 1-678) (GST tag) (ABIN1351580)

DHX58 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP

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recommended

DHX58 Protein (AA 1-678) (Strep Tag) (ABIN3092156)

Crystallography grade DHX58 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS

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recommended

DHX58 Protein (AA 1-678) (Strep Tag) (ABIN3136923)

Crystallography grade DHX58 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS

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DHX58 Proteins by Grade

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DHX58 Proteins by Origin

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DHX58 Proteins by Source

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DHX58 Proteins by Protein Type

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DHX58 Proteins by Application

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Popular DHX58 Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

DHX58 Protein (AA 1-678) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1351580

Quantity 10 μg

Datasheet Datasheet

DHX58 Protein (AA 1-678) (Strep Tag)

Reactivity Human

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3092156

Quantity 1 mg

Datasheet Datasheet

DHX58 Protein (AA 1-678) (Strep Tag)

Reactivity Mouse

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3136923

Quantity 1 mg

Datasheet Datasheet

DHX58 Protein (Myc-DYKDDDDK Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2719466

Quantity 20 μg

Datasheet Datasheet

Aliases for DHX58 Proteins

DEXH-box helicase 58 L homeolog (dhx58.L) Proteins
DExH-box helicase 58 (DHX58) Proteins
DExH-box helicase 58 (dhx58) Proteins
probable ATP-dependent RNA helicase DHX58 (LOC100566102) Proteins
DEXH (Asp-Glu-X-His) box polypeptide 58 (dhx58) Proteins
DEXH (Asp-Glu-X-His) box polypeptide 58 (Dhx58) Proteins
DEXH-box helicase 58 (Dhx58) Proteins
B430001I08Rik Proteins
D11LGP2 Proteins
D11lgp2e Proteins
D11Lgp2e Proteins
DHX58 Proteins
lgp2 Proteins
LGP2 Proteins
Lgp2 Proteins
LPG2 Proteins
MGC82787 Proteins
RGD1310093 Proteins
RLR-3 Proteins

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Popular DHX58 Proteins

Aliases for DHX58 Proteins

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