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The protein encoded by DMC1 is essential for meiotic homologous recombination.
Showing 10 out of 135 products:
Human Monoclonal DMC1 Primary Antibody for IP, WB - ABIN151318
Masson, Davies, Hajibagheri, Van Dyck, Benson, Stasiak, Stasiak, West: The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51. in The EMBO journal 2000
Monoclonal DMC1 Primary Antibody for WB - ABIN534072
Massey, Kaushik, Sovak, Kiffin, Cuervo: Consequences of the selective blockage of chaperone-mediated autophagy. in Proceedings of the National Academy of Sciences of the United States of America 2006
The DMC1 was highly variable from cell to cell, whereas foci of the crossover marker MLH1 (show MLH1 Antibodies) showed little variability.
RAD51AP1 (show RAD51AP1 Antibodies) foci colocalize with a subset of DMC1 foci in spermatocytes.
p53 (show TP53 Antibodies) might be involved in homologous recombination and/or checkpoint function by directly binding to DMC1 protein to repress genomic instability in meiotic germ cells
TBPIP/HOP2 (show PSMC3IP Antibodies) directly binds to DNA and functions as an activator for DMC1 during the homologous pairing step in meiosis
data reveal an interplay among Hop2 (show PSMC3IP Antibodies), Mnd1 (show MND1 Antibodies) and Rad51 (show RAD51 Antibodies) and Dmc1 in the formation of the first recombination intermediates during meiosis
Mei1 (show MEI1 Antibodies) can be positioned upstream of Dmc1 in the genetic pathway that operates during mammalian meiosis
Dmc1(Mei11) exposes a sex difference in recombination in that a significant portion of female oocytes can compensate for DMC1 deficiency to undergo crossing-over and complete gametogenesis.
Data indicate that ahomologous pairing by DMC1 protein or RAD51 (show RAD51 Antibodies) recombinase (show RAG1 Antibodies) in chromatin containing nucleosome-depleted double-stranded DNA (dsDNA) regions.
BRCA2 (show BRCA2 Antibodies) protein stimulates DMC1-mediated DNA strand exchange between RPA (show RPA1 Antibodies)-ssDNA complexes and duplex DNA, thus identifying BRCA2 (show BRCA2 Antibodies) as a mediator of DMC1 recombination function.
Dmc1 can reject divergent DNA sequences while bypassing a few mismatches in the DNA sequence.
In contrast to RAD51 (show RAD51 Antibodies), stabilization of the presynaptic filament via ATP hydrolysis attenuation is insufficient for enhancement of the DMC1-catalyzed recombination reaction.
truncated DMC1 octamers further stack with alternate polarity into a filament
results suggested mutations in the coding sequence of DMC1 are not associated with premature ovarian failure in Chinese women
The results suggested that PSF (show IGFBP7 Antibodies) may function as an activator for the meiosis-specific recombinase (show RAG1 Antibodies) DMC1.
RAD51-associated protein 1 (RAD51AP1 (show RAD51AP1 Antibodies)) interacts with the meiotic recombinase (show RAG1 Antibodies) DMC1 through a conserved motif.
D-loops in a human DMC1-driven reaction are substantially more resistant to dissociation by branch-migration proteins such as RAD54 (show ATRX Antibodies) than those formed by RAD51 (show RAD51 Antibodies).
The protein encoded by this gene is essential for meiotic homologous recombination. Genetic recombination in meiosis plays an important role in generating diversity of genetic information. The product of this gene is structurally and evolutionary related to the products of the yeast RAD51 and E. coli RecA genes. Alternative splice variants of this gene have been described but their full-length nature has not been determined.
DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)
, RecA homolog Dmc1
, disrupted meiotic cDNA 1
, meiotic recombination protein DMC1/LIM15 homolog
, meiotic recombination protein DMC1/LIM15 homolog-like
, meiotic recombination protein dmc1/lim15-like protein
, disrupted meiotic cDNA 1 homolog
, DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination
, disrupted meiotic cDNA1, yeast, homolog of