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The protein encoded by DUSP9 is a member of the dual specificity protein phosphatase subfamily. Additionally we are shipping DUSP9 Antibodies (70) and DUSP9 Kits (10) and many more products for this protein.
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The results of this study, combined with previous studies, suggested that therapeutic intervention to increase the expression or activity of DUSP9 may enable the activation of anti-proliferation signals in malignant cells.
A possible use for DUSP9 as CIMP marker.
DUSP9 protein levels were markedly suppressed in severe pre-eclampsia, but not in severe IUGR. This suppression might be attributable to the prolonged hypoxic conditions found in pre-eclampsia.
The DUSP9 locus is a common susceptibility locus for type 2 diabetes across different ethnicities, and 6 loci identified in South Asian genome-wide association studies also have significant effect on susceptibility to Japanese type 2 diabetes.
decreased expression of DUSP-9 is associated with poor prognosis in ccRCC.
DUSP9/MKP-4 is a bona fide target of PKA signaling and attenuation of DUSP9/MKP-4 function can mediate cross-talk between the PKA pathway and MAPK signaling through both ERK1/2 and p38alpha in vivo
2.7 A resolution crystal structure of the catalytic domain of MKP-4 (MKP-4C) is presented
microtubule disruption by MKP4 provides a novel mechanism for tumor suppression by a cytosolic MKP
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus.
dual specificity protein phosphatase 9
, map kinase phosphatase 4
, mitogen-activated protein kinase phosphatase 4
, serine/threonine specific protein phosphatase
, dual-specificity MAP kinase phosphatase 4
, dual specificity phosphatase 9
, LOW QUALITY PROTEIN: dual specificity protein phosphatase 9