Hepatic and Glial Cell Adhesion Molecule Proteins (HEPACAM)

The protein encoded by HEPACAM is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. Additionally we are shipping Hepatic and Glial Cell Adhesion Molecule Antibodies (56) and Hepatic and Glial Cell Adhesion Molecule Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HEPACAM 220296 Q14CZ8
HEPACAM 72927 Q640R3
HEPACAM 521015 A4FUY1
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Top Hepatic and Glial Cell Adhesion Molecule Proteins at antibodies-online.com

Showing 9 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,355.45
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Mammalian Cells Human His tag   50 μg Log in to see 4 Days
$522.50
Details
Human Cells Human His tag,ECD 100 μg Log in to see 20 to 21 Days
$437.80
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,508.00
Details
Human Human His tag   10 μg Log in to see 15 to 16 Days
$300.00
Details

HEPACAM Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , ,
Mouse (Murine) ,
,
Cow (Bovine)

More Proteins for Hepatic and Glial Cell Adhesion Molecule (HEPACAM) Interaction Partners

Human Hepatic and Glial Cell Adhesion Molecule (HEPACAM) interaction partners

  1. hepaCAM associates with connexin 43 (show GJA1 Proteins), a main component of gap junctions, and enhances connexin 43 (show GJA1 Proteins) localization to the plasma membrane at cellular junctions.

  2. this study revealed that hepaCAM was downregulated in CRC (show CALR Proteins) tissues and cell lines. Overexpression of hepaCAM inhibited CRC (show CALR Proteins) cell proliferation, migration, and invasion in vitro. Furthermore, the tumorigenesis assay showed that increased expression of hepaCAM suppressed CRC (show CALR Proteins) tumor growth and metastasis in vivo.

  3. In a group of Egyptian patients with megalencephalic leukoencephalopathy, novel mutations were identified in HEPACAM.

  4. DNMT1 (show DNMT1 Proteins) up-regulation induced by IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) signaling was indispensable for IL-6 (show IL6 Proteins)-mediated hepaCAM loss in renal cell carcinoma (show MOK Proteins) (RCC (show XRCC1 Proteins)) cell lines ACHN (show LARP6 Proteins) and 769-P, while DNMT3b (show DNMT3B Proteins) up-regulation was crucial for hepaCAM loss in A498.

  5. Out of 20 patients, macrocephaly, classic MRI (show C7ORF49 Proteins) features, motor development delay and cognitive impairment were detected in 20(100%), 20(100%), 17(85%) and 4(20%) patients, respectively. 20(100%) were clinically diagnosed with MLC. 19(95%) were genetically diagnosed with 10 novel mutations in MLC1, MLC1 and GlialCAM mutations were identified in 15 and 4 patients, respectively

  6. HepaCAM depletion was discovered in bladder cancer tissues compared with adjacent normal tissues, and the decreased level was associated with the degradation of FoxO3 (show FOXO3 Proteins).

  7. HepaCAM proteins were significantly decreased in bladder carcinoma. Low hepaCAM was not statistically associated with clinicopathological characteristics of the patients. HepaCAM overexpression activated caspase 3 (show CASP3 Proteins)/8/9, downregulated poly-ADP ribose polymerase (show PARP1 Proteins) and p-SMAD2 (show SMAD2 Proteins)/3, and decreased apoptosis.

  8. The suppressive roles of HEPACAM in NSCLC.

  9. Due to the ability to reactivate expression of hepaCAM and inhibit growth of bladder cancer cells, AZAC may represent an effective treatment for bladder cancer.

  10. The extracellular domain of GlialCAM is necessary for cell junction targeting and for mediating interactions with itself or with MLC1 and ClC-2 (show CLCN2 Proteins).

Mouse (Murine) Hepatic and Glial Cell Adhesion Molecule (HEPACAM) interaction partners

  1. we demonstrate an evolutionary conserved role for MLC1 in regulating glial surface levels of GLIALCAM, and this interrelationship explains why patients with mutations in either gene (MLC1 or GLIALCAM) share the same clinical phenotype.

  2. Data indicate that membrane protein MLC1 is crucial for proper localization of adhesion molecule (show NCAM1 Proteins) GlialCAM and chloride channel (show CLCA1 Proteins) ClC-2 (show CLCN2 Proteins), and for changing ClC-2 (show CLCN2 Proteins) currents.

  3. GlialCAM, an immunoglobulin-like cell adhesion molecule (show MCAM Proteins) is expressed in glial cells of the central nervous system.

Hepatic and Glial Cell Adhesion Molecule (HEPACAM) Protein Profile

Protein Summary

The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene.

Gene names and symbols associated with HEPACAM

  • hepatic and glial cell adhesion molecule (HEPACAM)
  • hepatocyte cell adhesion molecule (Hepacam)
  • 2900042E01Rik protein
  • GlialCAM protein
  • Hepn1 protein
  • MLC2A protein
  • MLC2B protein

Protein level used designations for HEPACAM

hepatocyte cell adhesion molecule , protein hepaCAM

GENE ID SPECIES
100064233 Equus caballus
220296 Homo sapiens
489305 Canis lupus familiaris
521015 Bos taurus
72927 Mus musculus
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