anti-Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) Antibodies

HPGD encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. Additionally we are shipping HPGD Kits (22) and HPGD Proteins (17) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HPGD 15446 Q8VCC1
HPGD 79242 O08699
HPGD 3248 P15428
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Top anti-HPGD Antibodies at antibodies-online.com

Showing 10 out of 144 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (fro), IHC (p), SimWes, WB Simple Western: 15-PGDH/HPGD Antibody [ABIN152315] - Simple Western lane view shows a specific band for 15-PGDH/HPGD in 0.5 mg/ml of Lovo (left) and HeLa (right) lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. 0.1 mL Log in to see 7 to 9 Days
$488.73
Details
Human Goat Un-conjugated ELISA, IHC, WB ABIN185316 (0.1µg/ml) staining of Human Duodenum lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$429.84
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of HPGD Antibody (C-term) (ABIN390765) in MDA-MB231 cell line lysates (35 µg/lane). HPGD (arrow) was detected using the purified polyclonal antibody. HPGD Antibody (C-term) (ABIN390765) IHC analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Mouse Un-conjugated FACS, IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: HPGD Antibody [NBP1-87062] - Lane 1: Marker [kDa] 229, 112, 84, 48, 32, 27, 17.Lane 2: Human cell line RT-4 Immunocytochemistry/Immunofluorescence: HPGD Antibody [NBP1-87062] - Staining of human cell line U-251MG shows positivity in nucleus but not nucleoli & cytoplasm. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Mouse Un-conjugated ELISA, IHC, IHC (p), IP, WB 100 μg Log in to see 11 to 14 Days
$537.17
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p), WB Human Colon (formalin-fixed, paraffin-embedded) stained with HPGD antibody ABIN462285 followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. Human Liver (formalin-fixed, paraffin-embedded) stained with HPGD antibody ABIN462285 followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB ICC/IF Image Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using 15-PGDH, antibody at 1:200 dilution. WB Image Sample (30μg whole cell lysate) A:Raji , 12% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Goat Un-conjugated EIA, IHC (p), WB Human Colon (formalin-fixed, paraffin-embedded) stained with HPGDfollowed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Human Liver (formalin-fixed, paraffin-embedded) stained with HPGDfollowed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 6 to 8 Days
$495.00
Details

Top referenced anti-HPGD Antibodies

  1. Human Polyclonal HPGD Primary Antibody for ICC, IF - ABIN152315 : Giannoulias, Patel, Holloway, Lye, Tai, Challis: Differential changes in 15-hydroxyprostaglandin dehydrogenase and prostaglandin H synthase (types I and II) in human pregnant myometrium. in The Journal of clinical endocrinology and metabolism 2002 (PubMed)
    Show all 26 Pubmed References

  2. Polyclonal HPGD Primary Antibody for IF, WB - ABIN540849 : Ding, Tong, Liu, Moscow, Tai: NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer. in Carcinogenesis 2004 (PubMed)
    Show all 5 Pubmed References

  3. Human Polyclonal HPGD Primary Antibody for IF (p), IHC (p) - ABIN761711 : Wei, Yu, Shi, Zhang, Lian, Li, Shen, Xing, Zhu: 15-PGDH/15-KETE plays a role in hypoxia-induced pulmonary vascular remodeling through ERK1/2-dependent PAR-2 pathway. in Cellular signalling 2014 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal HPGD Primary Antibody for IHC (p), IHC - ABIN250327 : Coggins, Latour, Nguyen, Audoly, Coffman, Koller: Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus. in Nature medicine 2002 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal HPGD Primary Antibody for IHC, IHC (p) - ABIN4319762 : Wu, Hsu, Chen, Yu, Chang, Tai, Liu, Su, Chang, Yu: Candidate serological biomarkers for cancer identified from the secretomes of 23 cancer cell lines and the human protein atlas. in Molecular & cellular proteomics : MCP 2010 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal HPGD Primary Antibody for WB - ABIN516675 : Hughes, Otani, Yang, Newman, Yantiss, Altorki, Port, Yan, Markowitz, Mazumdar, Tai, Subbaramaiah, Dannenberg: NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer. in Cancer prevention research (Philadelphia, Pa.) 2009 (PubMed)

  7. Human Polyclonal HPGD Primary Antibody for IHC, WB - ABIN6681567 : Wu, Liu, Yang, Liu, Liu, Wang, Xiong, Yu, Huang, Zhuang: Association of 15-hydroxyprostaglandin dehydrogenate and poor prognosis of obese breast cancer patients. in Oncotarget 2017 (PubMed)

More Antibodies against HPGD Interaction Partners

Mouse (Murine) Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) interaction partners

  1. Finally, ATRA replacement suppressed 15-PGDH inhibition-induced tumor progression in KC mice, and ATRA treatment attenuated Aldh1 activity in tumor cells isolated from the pancreas of 15-Pgdh(-/-) KC mice. These findings provide evidence that 15-PGDH inhibition enhances KRAS-driven tumor progression via ATRA depletion in the pancreas. Therefore, ATRA replacement could be a potential strategy for PDAC treatment.

  2. down-regulation of 15-hydroxy prostaglandin dehydrogenase is crucial for Prostaglandin E2-induced cervical ripening and preterm birth.

  3. 15-PGDH prevents lipopolysaccharide-induced acute liver injury in mice.

  4. the protein level of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a key enzyme in prostaglandin metabolism, in Amyotrophic lateral sclerosis model mice at three different disease stages, was investigated.

  5. 15-PGDH is downregulated in human hepatoma cells with a high COX-2 expression, in chemical and genetic murine models of hepatocellular carcinoma (HCC) and in human HCC biopsies.

  6. Data from a mouse model suggest that expression of Hpgd protein in uterus is down-regulated in lipopolysaccharide/infection-induced embryo loss.

  7. prostaglandin E synthase (cPGES/p23) acts as a regulatory factor for expression of a prostaglandin E2 -inactivating enzyme,15-hydroxyprostaglandin dehydrogenase ( 15-PGDH).

  8. I. sinclarii is effective in lowering blood glucose due to the upregulation of glucokinase (Gk-rs1) and downregulation of hydroxyprostaglandin dehydrogenase.

  9. OAT-PG is proposed to be involved in the local PGE(2) clearance and metabolism for the inactivation of prostaglandin signals in the kidney cortex.

  10. novel tumor suppressive role for 15-PGDH due to loss of expression during colorectal tumor progression

  11. 15-Hydroxyprostaglandin dehydrogenase has a role in suppressing colon tumorigenesis

  12. The intrarenal distribution of 15-PGDH and its interactions with COX-2 suggest that differential regulation of COX-2 and 15-PGDH plays a role in determining levels of prostaglandins involved in regulation of salt, volume, and blood pressure homeostasis.

Guinea Pig Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) interaction partners

  1. Data indicate that 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor TD88 could be a good effector on wound healing, especially in the aspects of prevention of scarring.

  2. The data indicate that decreased expression of 15-hydroxyprostaglandin dehydrogenase in the fetal membranes may contribute to the increase in intrauterine prostaglandin concentrations at term, stimulating the onset of labor.

Human Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) interaction partners

  1. We describe for the first time an association between maternal smoking and HPGD expression. We propose that reduced expression of HPGD is one mechanism through which smoking may contribute to preterm labor.

  2. ROS-induced oxidation of Cys44 to sulfonic acid in 15-PGDH triggered its degradation via non-canonical ubiquitination- proteasome and autophagy pathways, whereas mutation of Cys44 to alanine abolished 15-PGDH degradation.

  3. Higher enzyme levels of 15-PGDH exist in the lumen of intracranial aneurysms of men compared with women. This observation could explain why aspirin confers better protection against IA rupture in men than in women.

  4. HPGD expression in colorectal cancer and its role in cetuximab resistance

  5. Results found that low 15-PGDH expression was significantly associated with advanced tumors, presence of lymph node metastasis and invasion, and poor prognosis in pancreatic ductal adenocarcinoma patients.

  6. The reduced 15-PGDH may result in PGE2 accumulation which sustains carcinogenesis and tumor progression. We further found that miR-21 exert its oncogenic role through PGE2/PI3K/Akt/Wnt/beta-catenin axis in gastric cell proliferation. In conclusion, our findings enlarged our knowledge in the roles of miR-21 in the progression of gastric cancer.

  7. WNT5A signaling regulates 15-PGDH expression.

  8. miR-21-HPGD regulatory module may play an important role as part of a feed-forward loop that regulates the PGE2 signaling. Such a feed-forward regulatory mechanism likely plays a critical role in OTSCC initiation and progression.

  9. inhibitory effects of 17-AAG on PGE2 levels in HT-29 colorectal cancer cells were mediated through modulating COX-2 and 15-PGDH expression.

  10. A common mutation and a novel mutation in HPGD gene were identified to be responsible for primary hypertrophic osteoarthropathy

  11. Peroxisome proliferator-activated receptors (PPARs) play pivotal roles in maintenance of Chorionic NAD-dependent 15-hydroxy prostaglandin dehydrogenase (PGDH) expression in chorion during human pregnancy.

  12. Neoadjuvant chemotherapy could increase 15-PGDH expression in advanced gastric cancer patients, and 15-PGDH may serve as a candidate prognostic biomarker of advanced GC response to therapy.

  13. 15-PGDH mRNA levels were significantly higher in aorta samples from patients undergoing abdominal aortic aneurysm repair than in those from healthy multiorgan donors.

  14. a homozygous 2-bp deletion (c.310_311delCT or p.L104AfsX3) was identified two primary hypertrophic osteoarthropathy siblings

  15. Omega-3 polyunsaturated fatty acids upregulate the expression of 15-PGDH by inhibiting miR-26a and miR-26b.

  16. Multiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancer.

  17. Loss of PGDH expression is associated with esophageal squamous cell carcinoma and adenocarcinoma.

  18. A single nucleotide polymorphism in the 3' untranslated region (UTR) of the 15-hydroxyprostaglandin dehydrogenase (HPGD) gene modifies mir-485-5p binding in breast cancer.

  19. Case Reports: novel 2-bp homozygous deletion was found in exon 3 (c.310-311delCT) of HPGD gene in the patients with Primary hypertrophic osteoarthropathy.

  20. Tissues from 15-PGDH knockout mice demonstrate similar increased regenerative capacity.

Cow (Bovine) Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) interaction partners

  1. HPGD may play a role during establishment and termination of gestation

HPGD Antigen Profile

Protein Summary

This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with HPGD

  • hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD) antibody
  • 15-hydroxyprostaglandin dehydrogenase L homeolog (hpgd.L) antibody
  • 15-hydroxyprostaglandin dehydrogenase (HPGD) antibody
  • 15-hydroxyprostaglandin dehydrogenase (hpgd) antibody
  • 15-hydroxyprostaglandin dehydrogenase (pgdh) antibody
  • 15-hydroxyprostaglandin dehydrogenase (PTRG_03214) antibody
  • 15-hydroxyprostaglandin dehydrogenase (VDBG_09957) antibody
  • hydroxyprostaglandin dehydrogenase 15 (NAD) (Hpgd) antibody
  • 15-hydroxyprostaglandin dehydrogenase (Hpgd) antibody
  • 15-PGDH antibody
  • AV026552 antibody
  • MGC79454 antibody
  • MGC80546 antibody
  • PGDH antibody
  • PGDH1 antibody
  • PHOAR1 antibody
  • SDR36C1 antibody

Protein level used designations for HPGD

15-hydroxyprostaglandin dehydrogenase , hydroxyprostaglandin dehydrogenase 15-(NAD) , 15-hydroxyprostaglandin dehydrogenase [NAD(+)] , PGDH , prostaglandin dehydrogenase 1 , 15-PGDH , NAD-dependent 15-hydroxyprostaglandin dehydrogenase , 15-hydroxyprostaglandin dehydrogenase (NAD+) , NAD+-dependent 15-hydroxyprostaglandin dehydrogenase , short chain dehydrogenase/reductase family 36C, member 1 , NAD+ dependent 15-hydroxyprostaglandin dehydrogenase

GENE ID SPECIES
422567 Gallus gallus
446811 Xenopus laevis
461613 Pan troglodytes
486073 Canis lupus familiaris
493354 Xenopus (Silurana) tropicalis
100009687 Equus caballus
100156186 Sus scrofa
100172788 Pongo abelii
100196521 Salmo salar
6341441 Pyrenophora tritici-repentis Pt-1C-BFP
9531736 Verticillium alfalfae VaMs.102
15446 Mus musculus
79242 Rattus norvegicus
100135538 Cavia porcellus
3248 Homo sapiens
512259 Bos taurus
101112958 Ovis aries
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