anti-Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) Antibodies

Mouse (Murine) Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) interaction partners

1. Finally, ATRA replacement suppressed 15-PGDH inhibition-induced tumor progression in KC mice, and ATRA treatment attenuated Aldh1 activity in tumor cells isolated from the pancreas of 15-Pgdh(-/-) KC mice. These findings provide evidence that 15-PGDH inhibition enhances KRAS-driven tumor progression via ATRA depletion in the pancreas. Therefore, ATRA replacement could be a potential strategy for PDAC treatment.

2. down-regulation of 15-hydroxy prostaglandin dehydrogenase is crucial for Prostaglandin E2-induced cervical ripening and preterm birth.

3. 15-PGDH prevents lipopolysaccharide-induced acute liver injury in mice.

4. the protein level of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a key enzyme in prostaglandin metabolism, in Amyotrophic lateral sclerosis model mice at three different disease stages, was investigated.

5. 15-PGDH is downregulated in human hepatoma cells with a high COX-2 expression, in chemical and genetic murine models of hepatocellular carcinoma (HCC) and in human HCC biopsies.

6. Data from a mouse model suggest that expression of Hpgd protein in uterus is down-regulated in lipopolysaccharide/infection-induced embryo loss.

7. prostaglandin E synthase (cPGES/p23) acts as a regulatory factor for expression of a prostaglandin E2 -inactivating enzyme,15-hydroxyprostaglandin dehydrogenase ( 15-PGDH).

8. I. sinclarii is effective in lowering blood glucose due to the upregulation of glucokinase (Gk-rs1) and downregulation of hydroxyprostaglandin dehydrogenase.

9. OAT-PG is proposed to be involved in the local PGE(2) clearance and metabolism for the inactivation of prostaglandin signals in the kidney cortex.

10. novel tumor suppressive role for 15-PGDH due to loss of expression during colorectal tumor progression

11. 15-Hydroxyprostaglandin dehydrogenase has a role in suppressing colon tumorigenesis

12. The intrarenal distribution of 15-PGDH and its interactions with COX-2 suggest that differential regulation of COX-2 and 15-PGDH plays a role in determining levels of prostaglandins involved in regulation of salt, volume, and blood pressure homeostasis.

Guinea Pig Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) interaction partners

1. Data indicate that 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor TD88 could be a good effector on wound healing, especially in the aspects of prevention of scarring.

2. The data indicate that decreased expression of 15-hydroxyprostaglandin dehydrogenase in the fetal membranes may contribute to the increase in intrauterine prostaglandin concentrations at term, stimulating the onset of labor.

Human Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) interaction partners

1. a novel homozygous missense mutation (c.577T>C) of the human HPGD gene in all affected members of a five-generation consanguineous Pakistani family harboring primary hypertrophic osteoarthropathy

2. We describe for the first time an association between maternal smoking and HPGD expression. We propose that reduced expression of HPGD is one mechanism through which smoking may contribute to preterm labor.

3. ROS-induced oxidation of Cys44 to sulfonic acid in 15-PGDH triggered its degradation via non-canonical ubiquitination- proteasome and autophagy pathways, whereas mutation of Cys44 to alanine abolished 15-PGDH degradation.

4. Higher enzyme levels of 15-PGDH exist in the lumen of intracranial aneurysms of men compared with women. This observation could explain why aspirin confers better protection against IA rupture in men than in women.

5. HPGD expression in colorectal cancer and its role in cetuximab resistance

6. Results found that low 15-PGDH expression was significantly associated with advanced tumors, presence of lymph node metastasis and invasion, and poor prognosis in pancreatic ductal adenocarcinoma patients.

7. The reduced 15-PGDH may result in PGE2 accumulation which sustains carcinogenesis and tumor progression. We further found that miR-21 exert its oncogenic role through PGE2/PI3K/Akt/Wnt/beta-catenin axis in gastric cell proliferation. In conclusion, our findings enlarged our knowledge in the roles of miR-21 in the progression of gastric cancer.

8. WNT5A signaling regulates 15-PGDH expression.

9. miR-21-HPGD regulatory module may play an important role as part of a feed-forward loop that regulates the PGE2 signaling. Such a feed-forward regulatory mechanism likely plays a critical role in OTSCC initiation and progression.

10. inhibitory effects of 17-AAG on PGE2 levels in HT-29 colorectal cancer cells were mediated through modulating COX-2 and 15-PGDH expression.

11. A common mutation and a novel mutation in HPGD gene were identified to be responsible for primary hypertrophic osteoarthropathy

12. Peroxisome proliferator-activated receptors (PPARs) play pivotal roles in maintenance of Chorionic NAD-dependent 15-hydroxy prostaglandin dehydrogenase (PGDH) expression in chorion during human pregnancy.

13. Neoadjuvant chemotherapy could increase 15-PGDH expression in advanced gastric cancer patients, and 15-PGDH may serve as a candidate prognostic biomarker of advanced GC response to therapy.

14. 15-PGDH mRNA levels were significantly higher in aorta samples from patients undergoing abdominal aortic aneurysm repair than in those from healthy multiorgan donors.

15. a homozygous 2-bp deletion (c.310_311delCT or p.L104AfsX3) was identified two primary hypertrophic osteoarthropathy siblings

16. Omega-3 polyunsaturated fatty acids upregulate the expression of 15-PGDH by inhibiting miR-26a and miR-26b.

17. Multiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancer.

18. Loss of PGDH expression is associated with esophageal squamous cell carcinoma and adenocarcinoma.

19. A single nucleotide polymorphism in the 3' untranslated region (UTR) of the 15-hydroxyprostaglandin dehydrogenase (HPGD) gene modifies mir-485-5p binding in breast cancer.

20. Case Reports: novel 2-bp homozygous deletion was found in exon 3 (c.310-311delCT) of HPGD gene in the patients with Primary hypertrophic osteoarthropathy.

Cow (Bovine) Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) interaction partners

1. HPGD may play a role during establishment and termination of gestation