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Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).. Additionally we are shipping IPP Isomerase 2 Antibodies (33) and many more products for this protein.
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significant positive fitness effect of IDI2, revealed by the pattern of sequence conservation, as well as its specific expression pattern underscores the importance of the IDI gene duplication
The present findings suggest that IDI1 and IDI2 may be associated with the production of cholesterol metabolites in neurons, leading to alpha-synuclein aggregation during the process of Lewy body formation.
Within the 40-kb region on 10p15.3 subtelomere, which harbours two genes encoding isopentenyl diphosphate isomerase 1 (IDI1) and IDI2, there was found a segmental copy-number gain in a large proportion of sporadic amyotrophic lateral sclerosis patients.
IDI2 is expressed at high levels only in skeletal muscle, where it may be involved in the specialized production of isoprenyl diphosphates for the posttranslational modification of proteins.
Enzyme kinetic analysis; both isozymes IDI1 (show IDI1 Proteins) and IDI2 are localized to the peroxisome by a PTS1-dependent pathway; data suggest that IDI2 is regulated independently from IDI1 (show IDI1 Proteins), by a mechanism that may involve PPARalpha (show PPARA Proteins)
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
IPP isomerase 2
, isopentenyl diphosphate delta-isomerase type 2
, isopentenyl pyrophosphate isomerase 2
, isopentenyl-diphosphate Delta-isomerase 2
, diphosphate dimethylallyl diphosphate isomerase 2