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CD300LF is an inhibitory receptor of the Ig superfamily expressed on myeloid cells. Additionally we are shipping Immune Receptor Expressed On Myeloid Cells 1 Antibodies (79) and Immune Receptor Expressed On Myeloid Cells 1 Kits (17) and many more products for this protein.
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Docking of the cocomplex structures onto a cryo-EM-derived model of MNoV suggests that each virion can make multiple CD300lf engagements, and thus, infection may be driven by the avidity of cell surface clustered CD300lf.
Our results indicate that direct interaction of MNV with two cell-surface molecules, CD300lf and CD300ld (show CD300LD Proteins), dictates permissive noroviral infection.
CD300f helps to maintain immune homeostasis by promoting macrophage clearance of self-antigens, while conversely inhibiting DC uptake and presentation of self-antigens.
dextran sodium sulfate-treated Cd300f-/- mice exhibit attenuated disease activity and histopathology in comparison with wild type controls
data highlight a previously unappreciated role for dendritic cells in controlling gut (show GUSB Proteins) homeostasis and show that CD300f-dependent regulation of apoptotic cell uptake is essential for suppressing overactive dendritic cell-mediated inflammatory responses, thereby controlling the development of chronic gut (show GUSB Proteins) inflammation.
ceramide-CD300f binding inhibits LPS (show TLR4 Proteins)-induced skin inflammation, implicating CD300f as a negative regulator of Toll-like receptor 4 (TLR4 (show TLR4 Proteins)) signaling in vivo
CD300lf is essential for murine noroviruse binding and replication in cell lines and primary cells.
CD300f is implicated in Wallerian degeneration and nerve regeneration by modulating both the influx and phenotype of macrophages
Y276 phosphorylation is necessary for enhanced CD300f-mediated phagocytosis through the recruitment of the p85alpha regulatory subunit of phosphatidylinositol-3-kinase
data highlight a previously unidentified role for CD300f in IL-4Ralpha-induced immune cell responses
this study demonstrates the role of CD300f in governing innate immune eosinophil activities in pediatric Crohn's disease patients and in active ulcerative colitis patients
findings suggest that two rare heterozygous truncating variations (RPS24 (show RPS24 Proteins) Q191X and CD300LF P261fsX266) are risk candidates for autism spectrum disorder.
CD300 molecules are all expressed by DC; CD300b (show TREM5 Proteins), d, e and f are restricted to different subpopulations of the myeloid DC lineage. They have been shown to regulate DC function both in vitro and in vivo.
The data suggest that the neuroprotective role of CD300f would be the result of a complex network of cell interactions.
peptides containing ITIM-like sequences of IREM-1 (CD300F) differentially regulate MyD88 (show MYD88 Proteins) and TRIF (show TRIM69 Proteins)-mediated TLR signalling
CD300f blocked the activation of cells induced by all TLR ligands
Data indicate that CD300F is an active regulator of TLR-mediated macrophage activation through association with SHP-1 (show PTPN6 Proteins) involving MyD88 (show MYD88 Proteins) and/or TRIF (show TRIM69 Proteins).
Findings indicate that IREM-1 exerted its inhibitory effect on BAFF-medicated signalling through ITIM-mediated regulation of ERK activities in THP-1 cells.
IgSF13 was identified from dendritic cells; preferentially expressed in myelo-monocytic cells, including monocytes, monocyte-derived DC and monocyte-related cell lines; may be involved in the negative regulation of specific leukocyte population [IgSF13]
a novel inhibitory receptor of the Ig superfamily in myeloid cells. (IREM-1 = immune receptor expressed on myeloid cells-1)
CD300LF is an inhibitory receptor of the Ig superfamily expressed on myeloid cells. It mediates negative regulatory signals by recruiting SHP1 (PTPN6\; MIM 176883) or SHIP (INPP5D\; MIM 601582) (Sui et al., 2004
CD300 antigen-like family member F
, CMRF-35-like molecule 1
, CMRF35-like molecule 1
, DC-derived Ig-like receptor 2
, leukocyte mono-Ig-like receptor 3
, myeloid-associated immunoglobulin-like receptor 5
, CD300 antigen like family member F
, CD300 molecule like family member f
, NK inhibitory receptor
, immune receptor expressed on myeloid cells 1
, immunoglobin superfamily member 13
, immunoglobulin superfamily member 13
, inhibitory receptor IREM1