anti-Integrin-Binding Sialoprotein (IBSP) Antibodies

The protein encoded by IBSP is a major structural protein of the bone matrix. Additionally we are shipping Integrin-Binding Sialoprotein Kits (15) and Integrin-Binding Sialoprotein Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IBSP 25373 P24090
IBSP 15891 Q61711
IBSP 3381 P21815
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Top anti-Integrin-Binding Sialoprotein Antibodies at

Showing 10 out of 85 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB IBSP Antibody (N-term) (ABIN658035) western blot analysis in CEM cell line lysates (35 µg/lane). This demonstrates the IBSP antibody detected the IBSP protein (arrow). 400 μL Log in to see 10 to 11 Days
Dog Rabbit Un-conjugated WB <b>WB Suggested Anti-IBSP Antibody Titration: </b>1.25ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
Human Mouse Un-conjugated EIA, IHC (fro), IF, IHC (p), RIA, WB 0.1 mg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated WB   100 μg Log in to see 4 to 6 Days
Human Chicken Un-conjugated EIA, FACS, IF, IHC (p), RIA, WB 0.1 mg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated IF (p), IHC (p), WB   100 μL Log in to see 3 to 7 Days
Human Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated IHC (p), WB Anti-Bone Sialoprotein antibody, IHC(P) IHC(P): Human Osteosarcoma Tissue 100 μg Log in to see 4 to 6 Days
Mouse Rabbit Un-conjugated IHC (p), WB Anti-Bone Sialoprotein antibody, Western blotting Lane 1: Rat Liver Tissue Lysate Lane 2: Rat Brain Tissue Lysate Lane 3: Rat Kidney Tissue Lysate Anti-Bone Sialoprotein antibody, IHC(P) IHC(P): Rat Liver Tissue 100 μg Log in to see 4 to 6 Days
Human Rat Un-conjugated EIA, WB 0.1 mg Log in to see 11 to 13 Days

IBSP Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus) , , ,

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Mouse (Murine) , , ,

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Human , , , ,
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Top referenced anti-Integrin-Binding Sialoprotein Antibodies

  1. Human Polyclonal IBSP Primary Antibody for IF (p), IHC (p) - ABIN748838 : Yang, Hai, Qin, Ti, Shangguan, Zhao, Wiggins, Liu, Feng, Chang, Wang, Liu: Cessation of epithelial Bmp signaling switches the differentiation of crown epithelia to the root lineage in a ?-catenin-dependent manner. in Molecular and cellular biology 2013 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Integrin-Binding Sialoprotein Interaction Partners

Mouse (Murine) Integrin-Binding Sialoprotein (IBSP) interaction partners

  1. In experimental autoimmune encephalomyelitis treated with interferon-beta (show IFNB1 Antibodies), OPN (show SPP1 Antibodies) was significantly decreased in splenocyte supernatants. Neutralizing OPN (show SPP1 Antibodies) antibodies offset the inhibitory effect of IFN-beta (show IFNB1 Antibodies) on Th17 cells. IFN-beta (show IFNB1 Antibodies) influenced the acetylation of the Opn (show SPP1 Antibodies) gene promoter. IFN-beta (show IFNB1 Antibodies) plays a role in Th17 differentiation partly through the inhibition of OPN (show SPP1 Antibodies).

  2. Osteopontin (show SPP1 Antibodies) plays a key role in vascular smooth muscle cell via signaling pathways involving AP-1 (show JUN Antibodies) and C/EBP beta (show CEBPB Antibodies), leading to increases in vascular smooth muscle cell proliferation and subsequent vascular remodeling.

  3. we disclosed the role of chemotaxis and apoptosis in the fibrotic microenvironment-enhanced seeding of tumor cells and identified the fibroblast-derived FN1 (show FN1 Antibodies) and SPP1 (show SPP1 Antibodies) as the central mediators in these processes

  4. Data show that, together, osteocalcin (OC (show BGLAP Antibodies)) and osteopontin (OPN (show SPP1 Antibodies)) play important roles in determining bone size, shape, and strength.

  5. Data indicate that BSP (show KLK6 Antibodies) is present in the calcified fibrocartilage of murine entheses and suggest that BSP (show KLK6 Antibodies) plays a regulatory role in this structure, influencing the growth of the calcified fibrocartilage in addition to the weakening of the tendon mechanical properties.

  6. AMPK (show PRKAA1 Antibodies) was sufficient to stimulate osteogenesis of MC3T3-E1 cells and inhibit adipogenesis of 3T3-L1 cells through the AMPK (show PRKAA1 Antibodies)-Gfi1 (show ZNF163 Antibodies)-OPN (show SPP1 Antibodies) axis.

  7. Excess osteopontin (show SPP1 Antibodies) exacerbated sarcolemmal injury, and correspondingly, that loss of osteopontin (show SPP1 Antibodies) reduced injury extent both in isolated myofibers and in muscle.

  8. A MMP-9-cleaved OPN fragment, OPN-32kDa, was responsible for inducing expansion of myeloid-derived suppressor cells, which may contribute to 3LL tumor's evasion of the immune response.

  9. OPN (show SPP1 Antibodies) played a critical role in activating the migration of Mesenchymal stem cells to injured sites and their differentiation into specific skin cell types during skin wound healing.

  10. Findings demonstrate that claudin-low mammary tumor cells rely on OPN (show SPP1 Antibodies) for proliferation, survival and migration as knockdown of OPN (show SPP1 Antibodies) using siRNA inhibited proliferation and migration while increasing apoptosis.

Human Integrin-Binding Sialoprotein (IBSP) interaction partners

  1. These data indicate that secretome derived from salivary gland cancer cells can influence the expression of two potential biomarkers of oral cancer-namely, bone sialoprotein (show CRISP1 Antibodies) (BSP (show KLK6 Antibodies)) and dentin sialoprotein (DSP (show DSPP Antibodies))-in normal salivary gland cells.

  2. In conclusion, serum levels of BSP, ALP, ICTP, and PSA increased in patients with bone metastases, and combined detection of all markers could improve the positive-predictive value.

  3. Preameloblast-Derived Factors Mediate Osteoblast Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Runx2 (show RUNX2 Antibodies)-Osterix (show SP7 Antibodies)-BSP (show KLK6 Antibodies) Signaling.

  4. Two significant SNPs within IBSP, rs1054627 and rs17013181, were associated with BMD (show BEST1 Antibodies) and postmenopausal osteoporosis by the two-stage strategy, and rs17013181 was also significantly associated with serum IBSP levels.

  5. Our results suggest that SSEA (show MPST Antibodies)-4 is a specific cell surface antigen (show CD53 Antibodies) that can be used to identify dental pulp stem cells.

  6. the strong correlation between bone sialoprotein (show CRISP1 Antibodies) and OPN (show SPP1 Antibodies) and papillary thyroid carcinoma suggests a role for BSP (show KLK6 Antibodies) and OPN (show SPP1 Antibodies) in calcification and tumor progression of papillary thyroid carcinoma

  7. oxidized low-density lipoprotein-induced expression dependent on Runx2 (show RUNX2 Antibodies) expression

  8. Bone sialoprotein (show CRISP1 Antibodies) could be a key mediator of the hypertrophic chondrocytes-induced angiogenesis of osteoarthritis.

  9. Current evidence demonstrates that BSP (show KLK6 Antibodies) and OPN (show SPP1 Antibodies), play significant roles in bone metastasis of osteotropic malignancies derived from breast, prostate, lung, thyroid, and multiple myeloma. [review]

  10. High expression of bone sialoprotein (show CRISP1 Antibodies) in breast neoplasms was associated with cytokeratin (show KRT4 Antibodies)-positive cells in bone marrow, but not with lymph node metastasis.

Integrin-Binding Sialoprotein (IBSP) Antigen Profile

Protein Summary

The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.

Gene names and symbols associated with IBSP

  • integrin binding sialoprotein (IBSP) antibody
  • integrin-binding sialoprotein S homeolog (ibsp.S) antibody
  • integrin-binding sialoprotein (ibsp) antibody
  • alpha-2-HS-glycoprotein (Ahsg) antibody
  • integrin binding sialoprotein (Ibsp) antibody
  • integrin-binding sialoprotein (Ibsp) antibody
  • secreted phosphoprotein 1 (Spp1) antibody
  • 2AR antibody
  • Aa2-066 antibody
  • Apl-1 antibody
  • BNSP antibody
  • Bsp antibody
  • BSP-II antibody
  • Bsp2 antibody
  • BSPI antibody
  • BSP II antibody
  • BSPII antibody
  • Eta antibody
  • ETA-1 antibody
  • IBSP antibody
  • OP antibody
  • Opn antibody
  • Opnl antibody
  • pp63 antibody
  • Ric antibody
  • SP-II antibody
  • Spp-1 antibody

Protein level used designations for IBSP

integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II) , integrin-binding sialoprotein , 59 kDa bone sialic acid-containing protein , BSP , alpha 2 HS-glycoprotein alpha 2 (fetuin) , fetuin-A , glycoprotein PP63 , phosphorylated N-glycoprotein pp63 , bone sialoprotein 2 , bone sialoprotein II , cell-binding sialoprotein , BSP II , integrin binding sialoprotein , Bone sialoprotein 2 , 44 kDa bone phosphoprotein , bone sialoprotein 1 , calcium oxalate crystal growth inhibitor protein , early T-lymphocyte activation 1 protein , minopontin , osteopontin , osteopontin-like protein

471249 Pan troglodytes
609146 Canis lupus familiaris
701835 Macaca mulatta
100192352 Xenopus laevis
100271750 Xenopus (Silurana) tropicalis
100344425 Oryctolagus cuniculus
25373 Rattus norvegicus
15891 Mus musculus
3381 Homo sapiens
24477 Rattus norvegicus
281233 Bos taurus
396071 Gallus gallus
397137 Sus scrofa
20750 Mus musculus
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