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The protein encoded by IBSP is a major structural protein of the bone matrix. Additionally we are shipping Integrin-Binding Sialoprotein Kits (14) and Integrin-Binding Sialoprotein Proteins (7) and many more products for this protein.
Showing 10 out of 85 products:
Human Polyclonal IBSP Primary Antibody for IF (p), IHC (p) - ABIN748838
Yang, Hai, Qin, Ti, Shangguan, Zhao, Wiggins, Liu, Feng, Chang, Wang, Liu: Cessation of epithelial Bmp signaling switches the differentiation of crown epithelia to the root lineage in a ?-catenin-dependent manner. in Molecular and cellular biology 2013
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In this study, the effect of deficiency of OPN (show SPP1 Antibodies) on intestinal tumor development in Apc (show APC Antibodies)-deficient Min mice was investigated.At 16 weeks of age, the number of small intestinal polyps in Min/OPN (show SPP1 Antibodies)(+/-) and Min/OPN (show SPP1 Antibodies)(-/-) mice was lower than that of Min/OPN (show SPP1 Antibodies)(+/+) mice. Colorectal tumor incidences and multiplicities in Min/OPN (show SPP1 Antibodies)(+/-) and Min/OPN (show SPP1 Antibodies)(-/-) mice were significantly lower than those in Min/OPN (show SPP1 Antibodies)(+/+) mice
Osteopontin (show SPP1 Antibodies) RNA aptamer is a novel and effective approach for preventing cardiac hypertrophy and fibrosis, improving cardiac function, and reversing pressure overload-induced heart failure.
OPN (show SPP1 Antibodies) deficiency reduced the incidence of chemically induced HCC (show FAM126A Antibodies) by suppressing EGFR (show EGFR Antibodies)-mediated anti-apoptotic signaling.
In experimental autoimmune encephalomyelitis treated with interferon-beta (show IFNB1 Antibodies), OPN (show SPP1 Antibodies) was significantly decreased in splenocyte supernatants. Neutralizing OPN (show SPP1 Antibodies) antibodies offset the inhibitory effect of IFN-beta (show IFNB1 Antibodies) on Th17 cells. IFN-beta (show IFNB1 Antibodies) influenced the acetylation of the Opn (show SPP1 Antibodies) gene promoter. IFN-beta (show IFNB1 Antibodies) plays a role in Th17 differentiation partly through the inhibition of OPN (show SPP1 Antibodies).
Osteopontin (show SPP1 Antibodies) plays a key role in vascular smooth muscle cell via signaling pathways involving AP-1 (show JUN Antibodies) and C/EBP beta (show CEBPB Antibodies), leading to increases in vascular smooth muscle cell proliferation and subsequent vascular remodeling.
we disclosed the role of chemotaxis and apoptosis in the fibrotic microenvironment-enhanced seeding of tumor cells and identified the fibroblast-derived FN1 (show FN1 Antibodies) and SPP1 (show SPP1 Antibodies) as the central mediators in these processes
Data show that, together, osteocalcin (OC (show BGLAP Antibodies)) and osteopontin (OPN (show SPP1 Antibodies)) play important roles in determining bone size, shape, and strength.
Results show that BSP (show KLK6 Antibodies) and OPN (show SPP1 Antibodies) are present in the mineralized tissues of fibrocartilaginous enthuses.
AMPK (show PRKAA1 Antibodies) was sufficient to stimulate osteogenesis of MC3T3-E1 cells and inhibit adipogenesis of 3T3-L1 cells through the AMPK (show PRKAA1 Antibodies)-Gfi1 (show ZNF163 Antibodies)-OPN (show SPP1 Antibodies) axis.
Excess osteopontin (show SPP1 Antibodies) exacerbated sarcolemmal injury, and correspondingly, that loss of osteopontin (show SPP1 Antibodies) reduced injury extent both in isolated myofibers and in muscle.
These data indicate that secretome derived from salivary gland cancer cells can influence the expression of two potential biomarkers of oral cancer-namely, bone sialoprotein (show CRISP1 Antibodies) (BSP (show KLK6 Antibodies)) and dentin sialoprotein (DSP (show DSPP Antibodies))-in normal salivary gland cells.
In conclusion, serum levels of BSP, ALP, ICTP, and PSA increased in patients with bone metastases, and combined detection of all markers could improve the positive-predictive value.
Preameloblast-Derived Factors Mediate Osteoblast Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Runx2 (show RUNX2 Antibodies)-Osterix (show SP7 Antibodies)-BSP (show KLK6 Antibodies) Signaling.
Two significant SNPs within IBSP, rs1054627 and rs17013181, were associated with BMD (show BEST1 Antibodies) and postmenopausal osteoporosis by the two-stage strategy, and rs17013181 was also significantly associated with serum IBSP levels.
Our results suggest that SSEA (show MPST Antibodies)-4 is a specific cell surface antigen (show CD53 Antibodies) that can be used to identify dental pulp stem cells.
the strong correlation between bone sialoprotein (show CRISP1 Antibodies) and OPN (show SPP1 Antibodies) and papillary thyroid carcinoma suggests a role for BSP (show KLK6 Antibodies) and OPN (show SPP1 Antibodies) in calcification and tumor progression of papillary thyroid carcinoma
oxidized low-density lipoprotein-induced expression dependent on Runx2 (show RUNX2 Antibodies) expression
Bone sialoprotein (show CRISP1 Antibodies) could be a key mediator of the hypertrophic chondrocytes-induced angiogenesis of osteoarthritis.
Current evidence demonstrates that BSP (show KLK6 Antibodies) and OPN (show SPP1 Antibodies), play significant roles in bone metastasis of osteotropic malignancies derived from breast, prostate, lung, thyroid, and multiple myeloma. [review]
High expression of bone sialoprotein (show CRISP1 Antibodies) in breast neoplasms was associated with cytokeratin (show KRT4 Antibodies)-positive cells in bone marrow, but not with lymph node metastasis.
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.
, bone sialoprotein 2
, bone sialoprotein II
, cell-binding sialoprotein
, integrin binding sialoprotein
, integrin-binding sialoprotein
, integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II)
, Bone sialoprotein 2