Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 Proteins (LETM1)

LETM1 encodes a protein that is localized to the inner mitochondrial membrane. Additionally we are shipping LETM1 Antibodies (76) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LETM1 3954 O95202
LETM1 56384 Q9Z2I0
Rat LETM1 LETM1 305457 Q5XIN6
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Top LETM1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,493.38
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,262.31
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details

LETM1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 (LETM1) Interaction Partners

Human Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 (LETM1) interaction partners

  1. these results revealed that the knockdown of LETM1 exhibited tumor suppressive effects, possibly by controlling the downstream Wnt/beta-catenin signaling pathway.

  2. Data indicate a positive association between LETM1 up-regulation, YAP1 nuclear localization and high PDGFB expression.

  3. LETM1 plays an important role in the progression of breast cancer

  4. LETM1 protein overexpression is associated with Triple negative breast cancer progression, and may be a potential biomarker for poor prognostic evaluation of Triple negative breast cancer.

  5. LETM1 plays an important role in the progression of head and neck squamous cell carcinoma.

  6. Letm1 expression is decreased in patients with intractable TLE and a rat model of epilepsy. Down-regulation of Letm1 leads to increases mitochondrial swelling and decreased MT-CYB expression, which is associated with susceptibility to seizures.

  7. Reconstitution of LETM1 or antioxidant overexpression rescued mitochondrial Ca(2+) transport and bioenergetics

  8. These findings identify novel cellular phenotypes in Wolf-Hirschhorn syndrome attributable to a 50% reduction in LETM1 expression level.

  9. Haploinsufficiency of WHSC1 and/or LETM1 contributes to Wolf-Hirschhorn Syndrome, but that loss of distinct and/or additional genes in 4p16.3 is necessary for the expression of the core Wolf-Hirschhorn Syndrome phenotype.

  10. NCLX, but not LETM1, mediates Ca(2+) extrusion from mitochondria. By controlling the duration of matrix Ca(2+) elevations, NCLX contributes to the regulation of NAD(P)H production and to the conversion of Ca(2+) signals into redox changes.

  11. Functional properties of Letm1 described in study are remarkably similar to those of the H(+)-dependent Ca(2+) transport mechanism identified in intact mitochondria.

  12. Data indicate that loss of Letm1 contributes to the pathology of Wolf-Hirschhorn syndrome and may contribute to seizure phenotypes by reducing glucose oxidation and other specific metabolic alterations.

  13. Summarizes the current state of the art about the functions of LETM1 and its role in pathophysiology, with some emphasis on whether it is a feasible candidate for regulation of mitochondrial Ca2+ homeostasis.

  14. Letm1 and UCP2/3 independently contribute to two distinct, mitochondrial Ca(2+) uptake pathways in intact endothelial cells.

  15. we have identified a novel submicroscopic duplication involving dosage sensitive genes TACC3, FGFR3, and LETM1.

  16. LETM1 suppressed lung cancer cell growth in vitro and in vivo.

  17. LETM1 is evolutionarily conserved throughout the eukaryotic kingdom and located in the mitochondria.

  18. Here, we present cellular and biochemical analysis of Letm1

  19. Study shows that human LETM1 is located in the inner membrane, exposed to the matrix and oligomerized in higher molecular weight complexes of unknown composition; down-regulation of LETM1 caused 'necrosis-like' death, without activation of caspases.

  20. the LETM1-mediated regulation of the mitochondrial volume and its interaction with the mitochondrial AAA-ATPase BCS1L that is responsible for three different human disorders

Mouse (Murine) Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 (LETM1) interaction partners

  1. This paper's findings delineate a mechanism by which PINK1 regulates mitochondrial Ca(2+) level through LETM1 and suggest a model by which PINK1 loss leads to deficient phosphorylation of LETM1 and impaired mitochondrial Ca(2+) transport.

  2. Reconstitution of LETM1 or antioxidant overexpression rescued mitochondrial Ca(2+) transport and bioenergetics

  3. Data indicate that cellular Letm1 knockdown reduced Ca(2+)mito uptake, H(+)mito extrusion and impaired mitochondrial ATP generation capacity.

LETM1 Protein Profile

Protein Summary

This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19.

Gene names and symbols associated with LETM1

  • leucine zipper and EF-hand containing transmembrane protein 1 (LETM1)
  • leucine zipper-EF-hand containing transmembrane protein 1 (letm1)
  • leucine zipper-EF-hand containing transmembrane protein 1 (LETM1)
  • LETM1 and EF-hand domain-containing protein 1, mitochondrial (LOC100346816)
  • leucine zipper-EF-hand containing transmembrane protein 1 (Letm1)
  • leucine zipper and EF-hand containing transmembrane protein 1 (Letm1)
  • letm1 protein
  • MGC145623 protein
  • wu:fc31h08 protein
  • wu:fc58h01 protein
  • zgc:109969 protein

Protein level used designations for LETM1

leucine zipper-EF-hand containing transmembrane protein 1 , LETM1 and EF-hand domain-containing protein 1, mitochondrial , fc31h08 , fc58h01 , let-m1 , leucine zipper-EF-hand-containing transmembrane protein 1 , Leucine zipper-EF-hand-containing transmembrane protein 1 , LETM1 and EF-hand domain-containing protein 1, mitochondrial-like , Mdm38 homolog

GENE ID SPECIES
461068 Pan troglodytes
570745 Danio rerio
780254 Xenopus (Silurana) tropicalis
100052731 Equus caballus
100346816 Oryctolagus cuniculus
100408245 Callithrix jacchus
100433508 Pongo abelii
100586576 Nomascus leucogenys
422898 Gallus gallus
3954 Homo sapiens
488807 Canis lupus familiaris
513324 Bos taurus
56384 Mus musculus
305457 Rattus norvegicus
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