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Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Additionally we are shipping MARK1 Proteins (7) and MARK1 Kits (6) and many more products for this protein.
Showing 10 out of 145 products:
Human Polyclonal MARK1 Primary Antibody for WB - ABIN391220
Drewes, Ebneth, Preuss, Mandelkow, Mandelkow: MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. in Cell 1997
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Human Polyclonal MARK1 Primary Antibody for IHC (p), WB - ABIN391219
Hezel, Gurumurthy, Granot, Swisa, Chu, Bailey, Dor, Bardeesy, Depinho: Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. in Molecular and cellular biology 2008
Show all 2 Pubmed References
In vitro kinase assays and metabolic-labeling experiments in living cells confirmed MARK1 as an LRRK2 substrate. Moreover, we also showed that LRRK2 and MARK1 are interacting in eukaryotic cells.
Overexpression and silencing of MARK1 resulted in significantly shorter dendrite length in mouse neocortical neurons and modified dendritic transport speed.
Low MARK1 is associated with cervical cancer.
Molecular determinants of KA1 (show GRIK4 Antibodies) domain-mediated autoinhibition and phospholipid activation of MARK1 kinase have been described.
the positioning of MARK/Par-1 (show MARK2 Antibodies) at the crosstalk of regulating cytoskeletal dynamics allows its participation in neuronal polarity decisions. [review]
LKB1 (show STK11 Antibodies) acts through its substrates of the microtubule affinity-regulating kinase family to regulate the localization of the polarity determinant Scribble (show SCRIB Antibodies) and the activity of the core Hippo kinases
In the Australian GWAS, the SNP rs7530302 near MARK1 on chromosome 1 (p=1.90 x 10(-9) achieved genomewide significance for comorbid AD/ND.
analysis of variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2 (show MARK2 Antibodies)
MARK1 was overexpressed in a prefrontal region in the brains of patients with Autism spectrum disorders.
Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3) (By similarity).
MAP/microtubule affinity-regulating kinase 1
, chemokine CCL-CUc
, serine/threonine-protein kinase MARK1
, serine/threonine-protein kinase MARK1-like
, ELKL motif serine-threonine protein kinase 3
, ELKL motif serine/threonine-protein kinase 3
, PAR1 homolog c