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ZAK is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). Additionally we are shipping ZAK Antibodies (70) and ZAK Kits (3) and many more products for this protein.
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Gene set enrichment analysis disclosed a significant correlation between ZAK+ colorectal premalignant lesions and gene sets belonging to the MAPK/ERK (show MAPK1 Proteins) and motility-related signaling pathways of the reactome database, strongly suggesting that ZAK induces such pro-tumoral reaction cascades in human cancers.
Recessive mutations in the kinase ZAK - novel cause of congenital myopathy.
ZAK is a key player in mammalian limb patterning in humans and mice.
ZAK kinase isoform TV1 is preferentially upregulated in gastric tumours and cell lines relative to normal samples. This pattern is also observed in colorectal, bladder and breast cancers.
The long non-coding RNA URHC promotes cell proliferation and inhibits apoptosis by repressing ZAK expression through inactivation of the ERK/MAPK (show MAPK1 Proteins) pathway.
we report that sorafenib suppresses UV-induced apoptosis specifically by inhibiting c-jun (show JUN Proteins)-NH(2)-kinase (JNK (show MAPK8 Proteins)) activation through the off-target inhibition of leucine zipper and sterile alpha motif-containing kinase (ZAK)
MRK (show ICK Proteins) is a novel RhoC (show RHOC Proteins) effector that controls LPA (show APOA Proteins)-stimulated cell invasion at least in part by regulating myosin dynamics, ERK (show EPHB2 Proteins) and p38 (show CRK Proteins)
The genes identified KTN1 (show KTN1 Proteins), ROCK1 (show ROCK1 Proteins), and ZAK may be responsible for loss of cellular homeostasis in giant cells tumors of bone
decrease of lung cancer cell proliferation by ZAK may involve the ERK (show EPHB2 Proteins) and JNK (show MAPK8 Proteins) pathways via an AP-1 (show FOSB Proteins) transcription factor.
In this study, by applying a novel method, we have identified the phosphorylation sites in human MSK1 mitogen- and stress-activated protein kinase 1 (show RPS6KA5 Proteins), and show that MRK (show ICK Proteins)-beta could also activate MSK1 (show RPS6KA5 Proteins) through direct interaction.
Zak-/- mice demonstrate a distinct ribotoxic stress-associated phenotype in response to ricin.
Exome sequencing analysis between SM/J and A/J mice identified 4 genes (Itga6 (show ITGA6 Proteins), Zak, Gpr155, and Mtx2 (show MTX2 Proteins)) with nonsynonymous coding SNPs. These four genes might be candidate genes for type 2 diabetes caused by gene-gene interactions.
PKNalpha (show PKN1 Proteins) functions as not only an upstream activator of MLTKalpha but also a putative scaffold protein (show HOMER1 Proteins) for the p38gamma (show MAPK12 Proteins) MAPK (show MAPK1 Proteins) signaling pathway
Results show that mixed lineage kinase-like mitogen-activated protein triple kinase (MLTK_-alpha plays a key role in the UVB- and EGF (show EGF Proteins)-induced phosphorylation of histone H3 (show HIST3H3 Proteins) at Ser28.
Mixed lineage kinase (show MAP3K12 Proteins) 7 (MLK7), a splice variant of the human ZAK gene (ortholog of mouse B230120H23Rik), encodes an isoform which is the MAPKKK required for modulation of the stress-activated MAPKs downstream of anisomycin and UV stimulation.
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
mitogen-activated protein kinase kinase kinase MLT
, MLK-like mitogen-activated protein triple kinase
, human cervical cancer suppressor gene 4 protein
, mixed lineage kinase 7
, mixed lineage kinase with a leucine zipper and a sterile alpha motif
, mixed lineage kinase-related kinase MRK-beta
, MLK-related kinase
, leucine zipper- and sterile alpha motif kinase ZAK
, mixed lineage kinase-related kinase
, sterile alpha motif- and leucine zipper-containing kinase AZK
, sterile-alpha motif and leucine zipper containing kinase AZK