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The protein encoded by NBR1 was originally identified as an ovarian tumor antigen monitored in ovarian cancer. Additionally we are shipping Neighbor of BRCA1 Gene 1 Antibodies (58) and Neighbor of BRCA1 Gene 1 Kits (7) and many more products for this protein.
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NBR1 is not required for PARK2-dependent mitophagy.
The NBR1 depletion impairs FA turnover and decreases targeting of autophagosomes to FAs, whereas ectopic expression of autophagy-competent, but not autophagy-defective, NBR1 enhances FA disassembly and reduces FA lifetime during migration.
NBR1 positively correlates with adipose inflammation in human obese patients.
Analysis of muscle biopsies of sporadic inclusion body myositis (sIBM) patients revealed a strong decrease of NBR1 phosphorylation in muscles of sIBM patients that directly correlated with the severity of protein aggregation.
The C-terminal fragments of SQSTM1 and NBR1 exhibited a dominant-negative effect against native SQSTM1/NBR1, probably by competing for LC3 and ubiquitin chain binding.
structure of the ubiquitin-associated (UBA) domain of human autophagy receptor NBR1 and its interaction with ubiquitin and polyubiquitin
results suggest that NBR1 is the specific autophagy receptor for pexophagy.
These findings suggest that NBR1 is involved in the formation of cytoplasmic inclusions in alpha-synucleinopathy.
The structural ensemble representing each of the two sequential folding transition transition states of the PB1 domain of NBR1 has been calculated using experimental Phi values and biased molecular dynamics simulations.
Autophagy-related NBR1 protein is not involved in the formation/degradation of neuronal intranuclear inclusions in neurodegenerative diseases.
Breast and ovarian cancer risk are high in Jewish women with BRCA1 genetic mutation.
AtNBR1 is more similar to mammalian NBR1 than to p62 in domain architecture and amino acid sequence.
Results indicate that the presence of a tryptophan residue in the LIR motif increases the binding affinity of GABARAPL-1/NBR1-LIR complex.
interacts with two proteins; fasciculation and elongation protein zeta-1 (FEZ1), a PKCzeta interacting protein, and calcium and integrin binding protein (CIB), also shows developmentally restricted expression in the neural tube
NBR1 together with p62 promotes autophagic degradation of ubiquitinated targets and simultaneously regulates their aggregation when autophagy becomes limited.
The nbr1 UBA domain binds to lysine-48 and -63 linked polyubiquitin-B chains. Nbr1 also binds to the autophagic effector protein LC3-A via a novel binding site.
findings suggest a critical function for NBR1 in the regulation of receptor trafficking and provide a mechanism for down-regulation of signaling by Spred2 via NBR1.
NBR1 is increased in adipose tissue macrophages in obese mice. The NBR1-MEKK3 complex is important in JNK activation in macrophages.
NBR1 phosphorylation by GSK3 at Thr586 prevents the aggregation of ubiquitinated proteins and their selective autophagic degradation.
In a mouse model of Huntington disease, NBR1 protein levels were decreased in all brain regions analyzed early in the disease, whereas at late stages they accumulated in the striatum and hippocampus, but not in the cortex.
MURF2 expression parallels that of the autophagy-associated proteins LC3, p62/SQSTM1 and nbr1
Results define Nbr1 as a negative regulator of ligand-mediated receptor tyrosine kinase degradation and reveal the interplay between its various regions for protein localization and function.
NBR1 is a novel PB1 adapter in Th2 differentiation and asthma.
might contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to mesothelin
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.
neighbor of BRCA1 gene 1
, next to BRCA1 gene 1 protein
, next to BRCA1 gene 1 protein-like
, cell migration-inducing gene 19 protein
, membrane component chromosome 17 surface marker 2
, membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125)
, migration-inducing protein 19
, neighbor of BRCA1 gene 1 protein
, protein 1A1-3B
, membrane component chromosome 17 surface marker 2 homolog
, next to the Brca1
, ovarian carcinoma antigen CA125