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The protein encoded by NBR1 was originally identified as an ovarian tumor antigen monitored in ovarian cancer. Additionally we are shipping Neighbor of BRCA1 Gene 1 Antibodies (60) and Neighbor of BRCA1 Gene 1 Kits (6) and many more products for this protein.
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NBR1 is not required for PARK2 (show PARK2 Proteins)-dependent mitophagy.
The NBR1 depletion impairs FA turnover and decreases targeting of autophagosomes to FAs (show FAS Proteins), whereas ectopic expression of autophagy-competent, but not autophagy-defective, NBR1 enhances FA disassembly and reduces FA lifetime during migration.
NBR1 positively correlates with adipose inflammation in human obese patients. (show MAP3K3 Proteins)
Analysis of muscle biopsies of sporadic inclusion body myositis (sIBM) patients revealed a strong decrease of NBR1 phosphorylation in muscles of sIBM patients that directly correlated with the severity of protein aggregation.
The C-terminal fragments of SQSTM1 and NBR1 exhibited a dominant-negative effect against native SQSTM1/NBR1, probably by competing for LC3 and ubiquitin chain binding.
structure of the ubiquitin-associated (UBA) domain of human autophagy receptor NBR1 and its interaction with ubiquitin and polyubiquitin (show UBB Proteins)
results suggest that NBR1 is the specific autophagy receptor for pexophagy.
These findings suggest that NBR1 is involved in the formation of cytoplasmic inclusions in alpha-synucleinopathy.
The structural ensemble representing each of the two sequential folding transition transition states of the PB1 (show SMR3A Proteins) domain of NBR1 has been calculated using experimental Phi values and biased molecular dynamics simulations.
Autophagy-related NBR1 protein is not involved in the formation/degradation of neuronal intranuclear inclusions in neurodegenerative diseases.
NBR1 is increased in adipose tissue macrophages in obese mice. The NBR1-MEKK3 (show MAP3K3 Proteins) complex is important in JNK (show MAPK8 Proteins) activation in macrophages.
NBR1 phosphorylation by GSK3 at Thr586 prevents the aggregation of ubiquitinated proteins and their selective autophagic degradation.
In a mouse model of Huntington disease (show HTT Proteins), NBR1 protein levels were decreased in all brain regions analyzed early in the disease, whereas at late stages they accumulated in the striatum and hippocampus, but not in the cortex.
MURF2 (show TRIM55 Proteins) expression parallels that of the autophagy-associated proteins LC3 (show MAP1LC3A Proteins), p62/SQSTM1 (show SQSTM1 Proteins) and nbr1
Results define Nbr1 as a negative regulator of ligand-mediated receptor tyrosine kinase (show ERBB3 Proteins) degradation and reveal the interplay between its various regions for protein localization and function.
NBR1 is a novel PB1 (show GPR97 Proteins) adapter in Th2 differentiation and asthma.
might contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to mesothelin (show MSLN Proteins)
The nbr1 UBA domain binds to lysine-48 and -63 linked polyubiquitin-B (show UBB Proteins) chains. Nbr1 also binds to the autophagic effector protein LC3 (show MAP1LC3A Proteins)-A via a novel binding site.
findings suggest a critical function for NBR1 in the regulation of receptor trafficking and provide a mechanism for down-regulation of signaling by Spred2 (show SPRED2 Proteins) via NBR1.
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.
neighbor of BRCA1 gene 1
, next to BRCA1 gene 1 protein
, next to BRCA1 gene 1 protein-like
, cell migration-inducing gene 19 protein
, membrane component chromosome 17 surface marker 2
, membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125)
, migration-inducing protein 19
, neighbor of BRCA1 gene 1 protein
, protein 1A1-3B
, membrane component chromosome 17 surface marker 2 homolog
, next to the Brca1
, ovarian carcinoma antigen CA125