Oligonucleotide/oligosaccharide-Binding Fold Containing 1 (OBFC1) ELISA Kits

OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009. Additionally we are shipping Oligonucleotide/oligosaccharide-Binding Fold Containing 1 Antibodies (48) and Oligonucleotide/oligosaccharide-Binding Fold Containing 1 Proteins (13) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
OBFC1 79991 Q9H668
OBFC1 108689 Q8K2X3
OBFC1 294025 Q6AYD2
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Top Oligonucleotide/oligosaccharide-Binding Fold Containing 1 ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 3.9 pg/mL 15.6-1000 pg/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$910.56
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Rat
  96 Tests Log in to see 15 to 18 Days
$875.60
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Mouse
  96 Tests Log in to see 15 to 18 Days
$875.60
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Cow
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$1,029.60
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More ELISA Kits for Oligonucleotide/oligosaccharide-Binding Fold Containing 1 Interaction Partners

Human Oligonucleotide/oligosaccharide-Binding Fold Containing 1 (OBFC1) interaction partners

  1. CTC1 (show CTC1 ELISA Kits)/STN1 (show STON1 ELISA Kits)/TEN1 (CST (show GAL3ST1 ELISA Kits)) deficiency diminishes HU-induced RAD51 (show RAD51 ELISA Kits) foci formation.

  2. STN1 (show STON1 ELISA Kits)-POLA2 (show POLA2 ELISA Kits) interaction provides a basis for primase-polymerase alpha stimulation by human STN1 (show STON1 ELISA Kits). A disease-causing mutation in human STN1 (show STON1 ELISA Kits) engenders a selective defect in POLA2 (show POLA2 ELISA Kits)-binding.

  3. The findings imply that theCTC1/STN1/TEN1 complex(CST )complex plays an important role in regulating telomere maintenance in alternative-lengthening of telomeres(ALT) cells.

  4. TERT-mediated G-strand extension and Ctc1-Stn1-Ten1-mediated C-strand fill-in are equally important for telomere length maintenance.

  5. Mutations in STN1 (show STON1 ELISA Kits) cause Coats plus syndrome and are associated with genomic and telomere defects.

  6. The mammalian CST (show GAL3ST1 ELISA Kits) (CTC1 (show CTC1 ELISA Kits)-STN1 (show STON1 ELISA Kits)-TEN1) complex is directly involved at several stages of telomere end formation and CST (show GAL3ST1 ELISA Kits) seems to play critical roles in coordinating telomerase elongation and fill-in synthesis to telomere replication.

  7. we explored two SNPs in genes associated either with telomere biology (OBFC1) or with LTL (OBCF1 and CTC1 (show CTC1 ELISA Kits)). Interestingly, we observed that genetic variation does not account for LTL at birth

  8. A 2-SNP OBFC1 haplotype was associated with higher risk of CHD (show CHDH ELISA Kits), and a 3-SNP TERC haplotype was associated with both higher risk of CHD (show CHDH ELISA Kits) and T2D.

  9. The Stn1 deficiency leads to persistent and elevated association of DNA polymerase alpha to telomeres, suggesting that Stn1 may modulate the DNA synthesis activity of polalpha rather than controlling the loading of polalpha to telomeres.

  10. the requirement for STN1 (show STON1 ELISA Kits)/CST (show GAL3ST1 ELISA Kits) in telomere duplex replication correlates with increasing telomere length and replication stress.

Mouse (Murine) Oligonucleotide/oligosaccharide-Binding Fold Containing 1 (OBFC1) interaction partners

  1. OBFC1 is identical to the previously described 44 kDa subunit of DNA-pol-alpha/primase associated factor (AAF) which increases polymerase-alpha/primase template affinity and stimulate both DNA primase and polymerase-alpha activities in vitro.

Arabidopsis thaliana Oligonucleotide/oligosaccharide-Binding Fold Containing 1 (OBFC1) interaction partners

  1. STN1 plays a genome-wide role in DNA replication and telomere stability.

  2. POT1a promotes an extendable telomere state via contacts with the telomerase RNP as well as STN1 and CTC1, while TEN1 opposes these functions.

  3. findings indicate that ATR and CST (CTC1/STN1/TEN1) act synergistically to maintain genome integrity and telomere length homeostasis

  4. AtSTN1 is a crucial component of the protective telomere cap in Arabidopsis, and likely in other multicellular eukaryotes. (AtSTN1)

  5. CTC1 (show CTC1 ELISA Kits) participates in telomere maintenance in diverse species and that a CST (show GAL3ST1 ELISA Kits)-like complex is required for telomere integrity in multicellular organisms.

Oligonucleotide/oligosaccharide-Binding Fold Containing 1 (OBFC1) Antigen Profile

Antigen Summary

OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009

Gene names and symbols associated with OBFC1

  • STN1, CST complex subunit (STN1) antibody
  • STN1, CST complex subunit (Stn1) antibody
  • STN1, CST complex subunit (stn1) antibody
  • Nucleic acid-binding, OB-fold-like protein (STN1) antibody
  • 0610009H20Rik antibody
  • 2310057J23Rik antibody
  • AAF-44 antibody
  • AAF44 antibody
  • AI413458 antibody
  • ATSTN1 antibody
  • bA541N10.2 antibody
  • F10K1.17 antibody
  • F10K1_17 antibody
  • RP11-541N10.2 antibody
  • RPA-32 antibody
  • STN1 antibody
  • zgc:64174 antibody

Protein level used designations for OBFC1

CST complex subunit STN1 , alpha accessory factor 44 , oligonucleotide/oligosaccharide-binding fold-containing protein 1 , replication protein A 32 kDa subunit , suppressor of cdc thirteen homolog , alpha-accessory factor of 44 kDa

GENE ID SPECIES
79991 Homo sapiens
108689 Mus musculus
294025 Rattus norvegicus
514213 Bos taurus
393360 Danio rerio
837223 Arabidopsis thaliana
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