anti-Palmitoyl-Protein Thioesterase 1 (PPT1) Antibodies

The protein encoded by PPT1 is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. Additionally we are shipping PPT1 Proteins (14) and PPT1 Kits (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PPT1 5538 P50897
PPT1 19063 O88531
PPT1 29411 P45479
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Top anti-PPT1 Antibodies at antibodies-online.com

Showing 10 out of 106 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB IHC(P): Human Intestinal Cancer Tissue 100 μg Log in to see 4 to 6 Days
$280.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IHC, IHC (p), WB 100 μL Log in to see 7 to 9 Days
$507.83
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated WB All lanes : Anti-PPT1 Antibody (C-term) at 1:2000 dilution Lane 1: Hela whole cell lysates Lane 2: HepG2 whole cell lysates Lysates/proteins at 20 μg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 34 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:2000 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of PPT1 Antibody (C-term) (ABIN389117) in 293 cell line lysates (35 µg/lane). PPT1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with PPT1 antibody (C-term) (ABIN389117), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of hPPT1-C46 (ABIN389116) in mouse cerebellum tissue lysates (35 µg/lane).PPT1 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of PPT1 using Jurkat whole  lysates. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Used in DAB staining on fromalin fixed paraffin-embedded Testis tissue 100 μg Log in to see 15 to 18 Days
$360.00
Details

Top referenced anti-PPT1 Antibodies

  1. Human Monoclonal PPT1 Primary Antibody for WB - ABIN1944801 : Crews, Lane, Schreiber: Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal PPT1 Primary Antibody for IHC, IHC (p) - ABIN4347151 : Scifo, Szwajda, Soliymani, Pezzini, Bianchi, Dapkunas, Dębski, Uusi-Rauva, Dadlez, Gingras, Tyynelä, Simonati, Jalanko, Baumann, Lalowski: Quantitative analysis of PPT1 interactome in human neuroblastoma cells. in Data in brief 2015 (PubMed)

More Antibodies against PPT1 Interaction Partners

Human Palmitoyl-Protein Thioesterase 1 (PPT1) interaction partners

  1. Targeting PPT1 blocks mTOR (show FRAP1 Antibodies) signaling in a manner distinct from catalytic inhibitors, while concurrently inhibiting autophagy, thereby providing a new strategy for cancer therapy.

  2. the combination of elevated glycolysis and deficient MRPL13 (show MRPL13 Antibodies) activity was closely linked to CLN1-mediated tumor activity in human hepatoma cells

  3. Proteomics analysis on isolated cilia revealed 660 proteins, which differed in their abundance levels between wild type and Ppt1 knock out.

  4. we reveal the existence of a positive feedback loop, where palmitoylation of PPT1 results in decreased activity and subsequent elevation in the amount of palmitoylated proteins.

  5. analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma (show ARHGEF16 Antibodies) cells

  6. Data (including data from knockout mice) suggest that deficiency of PPT1 leads to accumulation of granular osmiophilic deposits in many cell types, especially in astrocytes. [review-like article]

  7. Data suggest that human monocytes and macrophages express PPT1; PPT1 appears to contribute 32-40% of 2-arachidonylglycerol hydrolysis activity in THP1 monocyte cell line.

  8. This neuroimaging finding in PPT1-related neuronal ceroid lipofuscinosis (show CLN6 Antibodies) was not previously reported.

  9. Stop codon read-through with PTC124 induces palmitoyl-protein thioesterase-1 activity, reduces thioester load and suppresses apoptosis in cultured cells from Infantile neuronal ceroid lipofuscinosis (show CLN6 Antibodies) patients.

  10. Results describe the correlation between the three-dimensional structural changes in mutant palmitoyl protein thioesterase 1 and biochemical phenotypes.

Mouse (Murine) Palmitoyl-Protein Thioesterase 1 (PPT1) interaction partners

  1. Our results indicate that PPT1 deficiency causes alterations in the mitochondrial respiratory chain.

  2. Proteomics analysis on isolated cilia revealed 660 proteins, which differed in their abundance levels between wild type and Ppt1 knock out.

  3. In the novel Cln1(R151X) mouse model of INCL.

  4. Parkinson-like motor/sensorimotor deficits in Cln1-/- mice are not mediated by dopamine deficiency.

  5. Data show that Cln1 mutations disrupt the maturation of cathepsin D (show CTSD Antibodies) in lysosome contributing to neuropathology of infantile neuronal ceroid lipofuscinoses and suggest cathepsin D (show CTSD Antibodies) deficiency to be common link between infantile and congenital form.

  6. The authors have generated a Cln1 R151X point mutation mouse model that recapitulates the molecular, neuropathological and behavioral phenotypes of neuronal ceroid lipofuscinoses.

  7. Data (including data from knockout mice) suggest that deficiency of Ppt1 leads to accumulation of granular osmiophilic deposits in many cell types, especially in astrocytes. [review-like article]

  8. Data suggest that mouse macrophages express PPT1; PPT1 appears to contribute to 2-arachidonylglycerol hydrolysis activity in peritoneal macrophages in culture.

  9. The simultaneous loss of both Cln1 and Cln5 (show CLN5 Antibodies) genes might enhance the typical pathological phenotypes of these mice by disrupting or downregulating shared or convergent pathogenic pathways.

  10. These results uncover a previously unknown phenotype associated with PPT1 deficiency, that of altered thermoregulation, which is associated with impaired lipolysis and neurotransmitter release to brown adipose tissue during cold exposure.

PPT1 Antigen Profile

Protein Summary

The protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. Defects in this gene are a cause of infantile neuronal ceroid lipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis 4 (CLN4). Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PPT1

  • palmitoyl-protein thioesterase 1 (PPT1) antibody
  • palmitoyl-protein thioesterase 1 (MGYG_00692) antibody
  • palmitoyl-protein thioesterase 1 (Ppt1) antibody
  • Palmitoyl-protein thioesterase 1 (ppt-1) antibody
  • palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) (ppt1) antibody
  • palmitoyl-protein thioesterase 1 L homeolog (ppt1.L) antibody
  • 9530043G02Rik antibody
  • AA960502 antibody
  • C77813 antibody
  • CLN1 antibody
  • D4Ertd184e antibody
  • INCL antibody
  • Ppt antibody
  • PPT-1 antibody
  • ppt1 antibody
  • wu:fj17f04 antibody
  • zgc:63969 antibody

Protein level used designations for PPT1

ceroid-palmitoyl-palmitoyl-protein thioesterase 1 , palmitoyl-protein hydrolase 1 , palmitoyl-protein thioesterase 1 , PPT-1 , palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) , palmitoyl protein thioesterase , Palmitoyl-protein hydrolase 1 , palmitoyl-protein thioesterase 1 L homeolog

GENE ID SPECIES
5538 Homo sapiens
10031925 Arthroderma gypseum CBS 118893
19063 Mus musculus
29411 Rattus norvegicus
419681 Gallus gallus
475316 Canis lupus familiaris
281421 Bos taurus
191744 Caenorhabditis elegans
406648 Danio rerio
100720295 Cavia porcellus
102126191 Macaca fascicularis
100037210 Xenopus laevis
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