anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (Episodic Ataxia with Myokymia) (KCNA1) Antibodies

KCNA1 encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. Additionally we are shipping KCNA1 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNA1 3736 Q09470
KCNA1 16485 P16388
KCNA1 24520 P10499
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Top anti-KCNA1 Antibodies at antibodies-online.com

Showing 10 out of 140 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Mammalian Mouse Un-conjugated ISt, IHC, WB   5 mL 2 to 6 Days
$394.53
Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-KCNA1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Human Stomach 100 μL 2 to 3 Days
$289.00
Details
Mammalian Mouse Un-conjugated ISt, IHC, WB   100 μL 2 to 6 Days
$394.53
Details
Dog Rabbit Un-conjugated IP, WB Western blot analysis of Kv1.1 expression in HEK293 (A), MCF7 (B) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated WB Anti-Kv1.1 potassium channel antibody, All Western blottingAll lanes: Anti-KCNA1 at 0.5ug/ml  Lane 1: Rat Brain Tissue Lysate at 40ug  Lane 2: Rat Testis Tissue Lysate at 40ug  Lane 3: Rat Cardiac Muscle Tissue Lysate at 40ug  Lane 4: HELA Whole Cell Lysate at 40ug  Lane 5: U87 Whole Cell Lysate at 40ug  Lane 6: SHG Whole Cell Lysate at 40ug  Lane 7: NEURO Whole Cell Lysate at 40ug Predicted bind size: 56KD Observed bind size: 56KD 100 μg 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HuvEc/MCF-7/HeLa cells, using KCNA1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, WB Western Blot (WB) analysis of specific cells using KV1.1 Polyclonal Antibody. 100 μL Available
$363.46
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Anti-KCNA1 / Kv1.1 antibody IHC staining of human brain, cerebellum, purine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959338 concentration 5 ug/ml. 50 μL 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of Phospho-KCNA1(Ser446) in lysates of HuvEc , using Phospho-KCNA1(Ser446) Antibody(ABIN6269504). 100 μL 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissuereacted with KCNA1 Antibody (Center) followed which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Western blot analysis of KCNA1 Antibody (Center) in Hela cell line lysates (35ug/lane). This demonstrates the KCNA1 antibody detected the KCNA1 protein (arrow). 0.4 mL 6 to 8 Days
$484.00
Details

Top referenced anti-KCNA1 Antibodies

  1. Mammalian Monoclonal KCNA1 Primary Antibody for ISt, IHC - ABIN1304742 : Lee, Royston, Vest, Ley, Lee, Bolton, Chung: N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity. in Molecular brain 2015 (PubMed)
    Show all 46 Pubmed References

  2. Mammalian Monoclonal KCNA1 Primary Antibody for ISt, IHC - ABIN1304744 : Sosanya, Brager, Wolfe, Niere, Raab-Graham: Rapamycin reveals an mTOR-independent repression of Kv1.1 expression during epileptogenesis. in Neurobiology of disease 2014 (PubMed)
    Show all 28 Pubmed References

  3. Dog (Canine) Polyclonal KCNA1 Primary Antibody for WB - ABIN2776084 : Tan, Lennon, Klein, Boeve, Pittock: Clinical spectrum of voltage-gated potassium channel autoimmunity. in Neurology 2008 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal KCNA1 Primary Antibody for WB - ABIN538241 : Roberds, Tamkun: Cloning and tissue-specific expression of five voltage-gated potassium channel cDNAs expressed in rat heart. in Proceedings of the National Academy of Sciences of the United States of America 1991 (PubMed)
    Show all 3 Pubmed References

More Antibodies against KCNA1 Interaction Partners

Human Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (Episodic Ataxia with Myokymia) (KCNA1) interaction partners

  1. Pathogenic mutation in KCNA1 gene is associated with Episodic Ataxia.

  2. This study investigated the tissue expression levels, alpha subunit composition and distribution of Shaker-related voltage-dependent potassium Kv1 channels in human hippocampus by combining western blotting experiments.

  3. we found a new mutation in KCNA1 (F303V) and demonstrated that the reduced current amplitudes and altered gating properties of the channel account for its pathophysiological impact.

  4. study suggests that these mutations in KCNA1 cause the Kv1.1 channel dysfunction, which leads to familial paroxysmal kinesigenic dyskinesia

  5. In this work, we showed that although both Kv1.1 and Kv1.3 channels are expressed in U87 (glioblastoma), MDA-MB-231 (breast cancer) and LS174 (colon adenocarcinoma) cells, these respond differently to KAaH1 or KAaH2, two homologous Kv1 blockers from scorpion venom

  6. A novel Kv1.1 mutation E283K is associated with a broader EA1 phenotype. Mutant channels show slower activation and positively shifted voltage dependence.

  7. Study reports a novel KCNA1 mutation associated with an episodic ataxia type 1 phenotype and a possible association with malignant hyperthermia (MH). The current report broadens the phenotypes associated with KCNA1 mutations to include possible susceptibility to MH.

  8. Mutation p.Arg324Thr in the KCNA1 gene is pathogenic and results in episodic ataxia type 1 through a dominant-negative effect.

  9. Pharmacogenetic and case-control study evaluated the role of the variants of KCNA1, KCNA2, and KCNV2 in the susceptibility and drug resistance of genetic generalized epilepsies and revealed no significant association between 8 variants of KCNA1, KCNA2, and KCNV2 genes and risk or drug resistance of genetic generalized epilepsies after a Bonferroni correction for multiple comparisons.

  10. we demonstrate that the pathophysiological impact of the I262T mutation entails altered channel gating and defective protein biosynthesis, both of which raise imperative questions that call for further elucidation of the structural and functional roles of the S3 transmembrane segment in Kv1.1 channels.

  11. Herein, we critically evaluate the molecular and biophysical characteristics of the KV1.1 protein in comparison with others and discuss their role in the greater penetrance of KCNA1 mutations in humans leading to the neurological signs of episodic ataxia type 1

  12. KCNA1 mutations should be considered in patients of all ages with episodic neurological phenotypes, even when ataxia is not present.

  13. These findings provide evidence of an intrinsic cardiac role of Kv1.1 channels and indicate that they may contribute to atrial repolarization and atrial fibrillation susceptibility.

  14. Fine-tuning of Kv1.1 surface expression by RNA editing might contribute to the complexity of neuronal Kv channel regulation.

  15. Novel mutations in KCNA1 genes are associated with episodic ataxia type 1.

  16. Using mutagenesis and analysis of gating currents from gating pore mutations in the Shaker Kv channel, we identified statistically highly significant correlations between VSD function and physicochemical properties of gating pore residues.

  17. The combination of copy number variant and SNPs in KCNA1 (and SCN1A) genes increased the risk for both epilepsy and premature death.

  18. New mutations (R167M, C185W and I407M) were identified in three out of the four families. When expressed in human embryonic kidney cells, all three new mutations resulted in a loss of K(v)1.1 channel function.

  19. characterization of mutations in the potassium channel Kv1.1

  20. NRG1 increased the intrinsic excitability of FS-PV interneurons which was mediated by increasing the near-threshold responsiveness and decreasing the voltage threshold for action potentials through Kv1.1

Mouse (Murine) Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (Episodic Ataxia with Myokymia) (KCNA1) interaction partners

  1. Strong extracellular acidification inhibits Kca1.1 lysosomal channel.

  2. This study demonstrated that Kcna1-null mice Altered circadian rhythms and oscillation of clock genes and sirtuin 1.

  3. KCNQ activation decreased seizure latency by >/=50% in Kcnq1 strain mice but had no effect in the Kcna1 strain. However, in simultaneous EEG and ECG recordings, KCNQ activation significantly reduced spontaneous seizure frequency in Kcna1-/- mice by ~60%. In Kcnq1 mice, KCNQ activation produced adverse cardiac effects including profound bradycardia and abnormal increases in heart rate variability and AV conduction blocks.

  4. Kcna1(-/-) mice, a model of sudden unexpected death in epilepsy, experienced an increase in basal respiratory drive, chronic oxygen desaturation, frequent apnea-hypopnea (A-H), an atypical breathing sequence of A-H-tachypnea-A-H, increased tidal volume, and hyperventilation induced by methacholine.

  5. the pore-forming subunit of the large conductance voltage and calcium-activated potassium (BK, Slo1, or KCa1.1) channels encoded by a single KCa1.1 gene assembles in a fourfold symmetric fashion. Functional diversity arises from two families of regulatory subunits, beta and gamma, which help define the range of voltages over which BK channels in a given cell are activated, thereby defining physiological roles

  6. The results of this study suggest that the accumulated rest deficiency is associated with sudden death in Kv1.1 KO mice.

  7. No evidence has been found for developmental compensation of inherited Kv1.1 dysfunction in a mouse model of presynaptic channelopathy.

  8. Kv1.1 defects abolish presynaptic spike width modulation by subthreshold somatic depolarization.

  9. Low-voltage-activated K(+) (gKL) and hyperpolarization-activated mixed cation conductances (gh) mediate currents, IKL and Ih, through channels of the Kv1 (KCNA) and HCN families respectively and give auditory neurons the temporal precision required for signaling information about the onset, fine structure, and time of arrival of sounds.

  10. we identify Kvbeta1.1 as a sensor of pyridine nucleotide changes and as a modulator of Kv4.2 gating, action potential duration, and ECG in the mouse heart.

  11. This study provide new insights into the dynamic and differential distribution of Kv1 channels and associated proteins during myelination.

  12. age-associated changes in Sphingolipid composition or CerS2 ablation upregulate K(Ca) 1.1 and impair Ca(2+) mobilization, which thereby induces contractile dysfunction of gastric smooth muscle.

  13. Kcna-1 null mice initially expressed only a few of the most severe seizure types that progressively increased in frequency and decreased in seizure severity

  14. Kv1.2 channels represent an important physiological link in electric field-induced cell migration.

  15. Spontaneous seizures in Kcna1-null mice activate Fos expression in select limbic circuits

  16. Data suggest that the behavioral effect of Kv1.1 deletion is primarily to impede binaural integration and thus to mimic monaural hearing.

  17. The Kv1.1 null mouse is a potential model for sudden unexpected death in epilepsy in patients

  18. Kv1.1 is modulated by ANK3 in conditions of high dietary magnesium

  19. heterozygous mice subjected to P6 hypoxia exhibit increased susceptibility to flurothyl-induced seizures

  20. these data indicate that loss of Kv1.1 enhances synaptic release in the CA3 region, which reduces spike timing precision of individual neurons leading to disorganization of network oscillatory activity and promotes the emergence of fast ripples.

KCNA1 Antigen Profile

Protein Summary

This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK).

Gene names and symbols associated with KCNA1

  • potassium voltage-gated channel subfamily A member 1 (KCNA1) antibody
  • potassium voltage-gated channel, shaker-related subfamily, member 1 (KCNA1) antibody
  • potassium voltage-gated channel, shaker-related subfamily, member 1 (Kcna1) antibody
  • potassium voltage-gated channel subfamily A member 1 (Kcna1) antibody
  • fragile site, aphidicolin type, common, fra(12)(q24) (FRA12E) antibody
  • AEMK antibody
  • AI840627 antibody
  • EA1 antibody
  • HBK1 antibody
  • HUK1 antibody
  • Kca1-1 antibody
  • Kcna antibody
  • KCNA1 antibody
  • Kcpvd antibody
  • Kv1.1 antibody
  • MBK1 antibody
  • mceph antibody
  • Mk-1 antibody
  • MK1 antibody
  • RBK1 antibody
  • Shak antibody

Protein level used designations for KCNA1

potassium voltage-gated channel subfamily A member 1 , voltage-gated K(+) channel HuKI , voltage-gated potassium channel HBK1 , voltage-gated potassium channel subunit Kv1.1 , potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) , voltage-gated potassium channel Kv1.1 , potassium voltage-gated channel, shaker-related subfamily, member 1 , voltage-gated potassium channel , potassium voltage-gated channel subfamily A member 1-like , MKI , brain potassium channel protein-1 , megencephaly , potassium voltage gated channel, shaker related subfamily, member 1 , IA , RBKI , RCK1 , potassium (K+) channel protein voltage dependent , potassium voltage gated channel shaker related subfamily member 1

GENE ID SPECIES
3736 Homo sapiens
428101 Gallus gallus
466928 Pan troglodytes
486732 Canis lupus familiaris
538703 Bos taurus
711630 Macaca mulatta
100037722 Oryctolagus cuniculus
100048962 Sus scrofa
100051648 Equus caballus
100395602 Callithrix jacchus
100431422 Pongo abelii
100469172 Ailuropoda melanoleuca
16485 Mus musculus
24520 Rattus norvegicus
100731979 Cavia porcellus
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