anti-Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) Antibodies

PDCD4 is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Additionally we are shipping PDCD4 Kits (19) and PDCD4 Proteins (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PDCD4 27250 Q53EL6
PDCD4 18569 Q61823
PDCD4 64031 Q9JID1
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Top anti-PDCD4 Antibodies at antibodies-online.com

Showing 10 out of 254 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry-Paraffin: PDCD4 Antibody [NBP1-83302] - Staining of human breast shows strong cytoplasmic positivity in glandular cells. Western Blot: PDCD4 Antibody [NBP1-83302] - Lane 1: Marker [kDa] 207, 110, 79, 49, 32, 25, 17.Lane 2: Human cell line RT-4 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PDCD4 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, IHC, WB Antibody (0.1µg/ml) staining of HeLa lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$429.62
Details
Human Rabbit Un-conjugated IHC (p), WB PDCD4 Antibody (Center) (ABIN657922) western blot analysis in HL-60 cell line lysates (35 µg/lane). This demonstrates the PDCD4 antibody detected the PDCD4 protein (arrow). ABIN2846869 staining PDCD4 in human breast tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody. Dilution: 1:25 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Mouse Un-conjugated EIA, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Mouse Un-conjugated IHC, ELISA, WB Antibody 200-301-964 has been tested in immunohistochemistry, analyzed by an anatomic pathologist and validated for use in IHC applications against formalin-fixed, paraffin-embedded human tissues. The antibody was serially diluted and tested at a range of concentrations on at least 22 different human formalin-fixed, paraffin archival tissues, and positive and negative tissues were scored and compared to the published literature on the expression and function of the gene. A representative image from positively stained small intestine shows the localization of the anti Pdcd4 antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain. Image provided courtesy of LifeSpan Biosciences, Seattle, WA Western blot using  Immunochemicals Protein A purified Mouse Monoclonal anti-Pdcd4 pS457 antibody against recombinant PDCD4 protein. Membrane was blocked in 1% BSA-TBS-T for 30 min RT and probed with 1° Ab Ms-A-Pdcd4pS457 1:1000 (o/n 4°C in 1% BSA-TBS-T) followed by 2° Ab Peroxidase Conjugated Rabbit anti Ms CUST10M Lot# 20121 at 1:40,000 in ABIN925618 30 min RT. Bands at ~62 kD and ~32 kD were detected. 100 μg Log in to see 5 to 7 Days
$583.50
Details
Chicken Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of PDCD4 (pS457) staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of PDCD4 (pS457) expression in HeLa (A), Jurkat (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$575.00
Details
Human Mouse Un-conjugated ELISA, IHC, IHC (p), WB Human Breast (formalin-fixed, paraffin-embedded) stained with PDCD4 antibody ABIN364343 at 5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. Human Spleen (formalin-fixed, paraffin-embedded) stained with PDCD4 antibody ABIN364343 at 5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 50 μL Log in to see 11 to 14 Days
$563.44
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HuvEc cells, K562 cells and COS-7 cells, using PDCD4 (Phospho-Ser67) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from 293 cells treated with serum 20% 15', using PDCD4 (Phospho-Ser457) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain, using PDCD4 (Phospho-Ser457) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details

Top referenced anti-PDCD4 Antibodies

  1. Human Polyclonal PDCD4 Primary Antibody for IHC, IHC (p) - ABIN4344378 : Baffa, Fassan, Volinia, OHara, Liu, Palazzo, Gardiman, Rugge, Gomella, Croce, Rosenberg: MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets. in The Journal of pathology 2009 (PubMed)
    Show all 7 Pubmed References

  2. Human Polyclonal PDCD4 Primary Antibody for IHC, ELISA - ABIN1002982 : Yang, Jansen, Komar, Zheng, Merrick, Costes, Lockett, Sonenberg, Colburn: The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. in Molecular and cellular biology 2002 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal PDCD4 Primary Antibody for IF (p), IHC (p) - ABIN731993 : Yuan, Han, Cong, Ge, Ma, Dai, Li, Bi: Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity. in International journal of nanomedicine 2014 (PubMed)
    Show all 2 Pubmed References

  4. Cow (Bovine) Polyclonal PDCD4 Primary Antibody for WB - ABIN2792230 : Yang, Cho, Zakowicz, Hegamyer, Sonenberg, Colburn: A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. in Molecular and cellular biology 2004 (PubMed)
    Show all 3 Pubmed References

  5. Human Polyclonal PDCD4 Primary Antibody for ELISA, IHC - ABIN4344376 : Jia, Teng, Zou, Fang, Wu, Liang, Ding: Xenon Protects Against Septic Acute Kidney Injury via miR-21 Target Signaling Pathway. in Critical care medicine 2015 (PubMed)
    Show all 2 Pubmed References

  6. Human Monoclonal PDCD4 Primary Antibody for IHC, ELISA - ABIN1043728 : Jansen, Camalier, Colburn: Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis. in Cancer research 2005 (PubMed)
    Show all 2 Pubmed References

  7. Human Monoclonal PDCD4 Primary Antibody for IHC, ELISA - ABIN1043755 : Huang, Wu, Loeb, Hsu, Heidersbach, Brincat, Horiuchi, Lebbink, Mo, Goga, McManus: Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 Pubmed References

  8. Human Polyclonal PDCD4 Primary Antibody for IP, IHC - ABIN129709 : Santhanam, Baker, Hegamyer, Kirschmann, Colburn: Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion. in Oncogene 2010 (PubMed)
    Show all 2 Pubmed References

  9. Human Polyclonal PDCD4 Primary Antibody for IHC (p), ELISA - ABIN2476088 : Palamarchuk, Efanov, Maximov, Aqeilan, Croce, Pekarsky: Akt phosphorylates and regulates Pdcd4 tumor suppressor protein. in Cancer research 2005 (PubMed)

  10. Human Polyclonal PDCD4 Primary Antibody for IF (p) - ABIN732000 : Choi, Kim, Suh, Byun, Jung, Sohn: The relevance of miRNA-21 in HSV-induced inflammation in a mouse model. in International journal of molecular sciences 2015 (PubMed)

More Antibodies against PDCD4 Interaction Partners

Human Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. the localization of Pdcd4 to the cytoplasm may be responsible for the suppression of the target mRNA translation and apoptosis.

  2. PDCD4 and PTEN were the functional targets of miR (show MLXIP Antibodies)-21.

  3. Various studies support evidence that PDCD4, is a novel tumor suppressor gene, and is downregulated or even absent in colorectal cancer (CRC (show CALR Antibodies)) and suppresses CRC (show CALR Antibodies) deterioration. [review]

  4. In the high malignant group the PDCD4 mRNA and PDCD5 (show PDCD5 Antibodies) mRNA expressions were significantly decreased compared with the low malignant group and the control group. PDCD4 mRNA and PDCD5 (show PDCD5 Antibodies) mRNA expressions are promising targets for the diagnosis and treatment of glioma.

  5. miR (show MLXIP Antibodies)-21 may promote salivary adenoid cystic carcinoma progression via PDCD4 and PTEN down-regulation and Bcl-2 (show BCL2 Antibodies) up-regulation.

  6. The expression of PDCD4 is decreased in cervical cancer tissues, compared to miR (show MLXIP Antibodies)-150 which is increased.

  7. Our study demonstrated that lncRNA-XIST, which acts as a miRNA sponge, impedes miR (show MLXIP Antibodies)-21-5p to maintain the expression of PDCD4, which contributes to the progression of osteosarcoma (OS). Our findings suggest that the newly identified XIST/miR (show MLXIP Antibodies)-21-5p/PDCD4 axis could be a potential biomarker or therapeutic target for OS.

  8. miR206 promoted the onset of SANFH by inducing apoptosis and suppressed the proliferation of osteoblasts, which was dependent on the inhibition of PDCD4.

  9. Results found PDCD4 as a target gene of miR (show MLXIP Antibodies)-93 and miR (show MLXIP Antibodies)-93 could down-regulate the expression of PDCD4 by directly targeting its 3'-UTR (show UTS2R Antibodies). The re-expression of PDCD4 could attenuate the hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cell invasion and migration induced by miR (show MLXIP Antibodies)-93, while the knockdown of PDCD4 would promote HCC (show FAM126A Antibodies) cell migration and invasion via the EMT (show ITK Antibodies) pathway.

  10. Reduced expression of PDCD4 was found in decidual and chorionic tissues, and peripheral blood mononuclear cells from patients with missed abortion.

Mouse (Murine) Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. These skeletal effects were attributed to inhibition of bone resorption and osteoclast function by miR (show MLXIP Antibodies)-21 deficiency through miR (show MLXIP Antibodies)-21 targeting programmed cell death 4 (PDCD4), despite the existence of RANKL (show TNFSF11 Antibodies). As far as we know, this is the first in vivo evidence of a pro-osteoclastic microRNA.

  2. MEG3 functions as a competing endogenous RNAs (ceRNAs) and competes with PDCD4 mRNA for directly binding to miR (show MLXIP Antibodies)-21, which mediates ischemic neuronal death.

  3. In colorectal cancer tissues, the Sin1 (show MAPKAP1 Antibodies) protein but not mRNA was significantly upregulated while Pdcd4 protein was downregulated, suggesting that loss of Pdcd4 might correlate with Sin1 (show MAPKAP1 Antibodies) protein level but not mRNA level in colorectal cancer.

  4. -induced expression of PDCD4 is associated with increased beta cell death.

  5. miR (show MLXIP Antibodies)-155 not only directly inhibited SOCS1 (show SOCS1 Antibodies) expression, but also increased the expression of p-STAT (show STAT1 Antibodies) and PDCD4, as well as the production of proinflammation mediators IL-6 (show IL6 Antibodies) and TNF-alpha (show TNF Antibodies) in atherogenesis

  6. our data suggest that Pdcd4 as a crucial regulator in SGs (show SKI Antibodies) induced by ox-LDL or HFD maybe a potential target for mitigating SG-associated stress responses in obesity and related diseases.

  7. Pdcd4 deficiency attenuates atherosclerosis in hyperlipidemic mice in part through the upregulation of the anti-inflammatory cytokine IL-10 (show IL10 Antibodies).

  8. PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6 (show IL6 Antibodies)/STAT3 (show STAT3 Antibodies) Pathway.

  9. Study found that miR-16 (show GDE1 Antibodies) was the direct regulatory element of PDCD4 and played a vital role in atherosclerosis by regulating PDCD4 and the downstream NF-kappaB (show NFKB1 Antibodies) and MAPK (show MAPK1 Antibodies) pathways.

  10. Pdcd4 produces unfavorable influences on adipose-derived stem cells(ADSC) stemness, which contribute to adipose dysfunction, obesity and metabolic syndromes, thereby proposing Pdcd4 as a potential intervening target for regulating ADSC cells function.

Zebrafish Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. miR (show MYLIP Antibodies)-21 plays a necessary role in cardiac valvulogenesis, in large part due to an obligatory downregulation of PDCD4

Pig (Porcine) Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-kappaB (show NFKB1 Antibodies)/ TNF-alpha (show TNF Antibodies) pathway in cardiomyocytes.

PDCD4 Antigen Profile

Protein Summary

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with PDCD4

  • programmed cell death 4 (PDCD4) antibody
  • programmed cell death 4 (Pdcd4) antibody
  • programmed cell death 4b (pdcd4b) antibody
  • programmed cell death 4 L homeolog (pdcd4.L) antibody
  • programmed cell death 4 (neoplastic transformation inhibitor) (PDCD4) antibody
  • programmed cell death 4 (pdcd4) antibody
  • cb45 antibody
  • D19Ucla1 antibody
  • Dug antibody
  • h731 antibody
  • Ma3 antibody
  • MGC69337 antibody
  • PDCD4 antibody
  • sb:cb45 antibody
  • Tis antibody
  • wu:fc84b08 antibody

Protein level used designations for PDCD4

neoplastic transformation inhibitor protein , nuclear antigen H731 , programmed cell death protein 4 , protein 197/15a , protein MA-3 , topoisomerase-inhibitor suppressed protein , death up-regulated gene protein , death-upregulated , protein I11/6 , programmed cell death 4 (neoplastic transformation inhibitor) , programmed cell death protein 4-like

GENE ID SPECIES
27250 Homo sapiens
18569 Mus musculus
64031 Rattus norvegicus
321061 Danio rerio
380222 Xenopus laevis
506724 Bos taurus
374191 Gallus gallus
407925 Xenopus (Silurana) tropicalis
450735 Pan troglodytes
477818 Canis lupus familiaris
695345 Macaca mulatta
100021762 Monodelphis domestica
100080517 Ornithorhynchus anatinus
100354557 Oryctolagus cuniculus
100413000 Callithrix jacchus
100469480 Ailuropoda melanoleuca
100584426 Nomascus leucogenys
100157112 Sus scrofa
100173014 Pongo abelii
100723476 Cavia porcellus
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