anti-Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) Antibodies

PDCD4 is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Additionally we are shipping PDCD4 Kits (16) and PDCD4 Proteins (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PDCD4 27250 Q53EL6
PDCD4 18569 Q61823
PDCD4 64031 Q9JID1
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Top anti-PDCD4 Antibodies at antibodies-online.com

Showing 10 out of 248 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-PDCD4 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated EIA, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Chicken Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of PDCD4 (pS457) staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of PDCD4 (pS457) expression in HeLa (A), Jurkat (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$575.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from 293 cells treated with serum 20% 15', using PDCD4 (Phospho-Ser457) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain, using PDCD4 (Phospho-Ser457) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from 293 cells, using PDCD4 (Ab-457) Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HeLa cells, using PDCD4 (Ab-457) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HuvEc cells, K562 cells and COS-7 cells, using PDCD4 (Phospho-Ser67) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IP, IHC, ELISA, WB Affinity purified anti-Pdcd4 was used at a 1:100 dilution to detect Pdcd4 by immunohistochemistry on mouse colon tissue. Tissue was fixed in 4% paraformaldehyde and paraffin embedded. Tissue sections were deparaffinized and treated by trypsinization before staining. 25 μL Log in to see 1 to 2 Days
$139.00
Details
Human Goat Un-conjugated ELISA, WB Western Blot: PDCD4 Antibody [NBP2-26139] - (0.1ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$485.88
Details
Human Goat Un-conjugated ELISA, WB Western Blot: PDCD4 Antibody [NBP2-26138] - (1ug/ml) staining of nuclear HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$485.88
Details
Human Mouse Biotin IHC, ELISA, WB Western Blot of Mouse anti-Pdcd4 phospho S457 Biotin Conjugated antibody. Lane 1: Pdcd4 recombinant protein. Lane 2: none. Load: 100 ng per lane. Primary antibody: Pdcd4 phospho S457 Biotin Conjugated antibody at 1:1,000 for overnight at 4°C. Secondary antibody: HRP Streptavidin secondary antibody at 1:40,000 for 30 min at RT. Block: MB-070 for 30 min at RT. Predicted/Observed size: 50 kDa, 50 kDa for Pdcd4 phospho S457. Other band(s): Pdcd4 phospho S457 splice variants and isoforms 50 μg Log in to see 1 to 2 Days
$300.00
Details

PDCD4 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-PDCD4 Antibodies

  1. Human Polyclonal PDCD4 Primary Antibody for IHC, IHC (p) - ABIN4344378 : Baffa, Fassan, Volinia, OHara, Liu, Palazzo, Gardiman, Rugge, Gomella, Croce, Rosenberg: MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets. in The Journal of pathology 2009 (PubMed)
    Show all 7 Pubmed References

  2. Human Polyclonal PDCD4 Primary Antibody for IHC, ELISA - ABIN1002982 : Yang, Jansen, Komar, Zheng, Merrick, Costes, Lockett, Sonenberg, Colburn: The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. in Molecular and cellular biology 2002 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal PDCD4 Primary Antibody for ELISA, IHC - ABIN4344376 : Jia, Teng, Zou, Fang, Wu, Liang, Ding: Xenon Protects Against Septic Acute Kidney Injury via miR-21 Target Signaling Pathway. in Critical care medicine 2015 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal PDCD4 Primary Antibody for IP, IHC - ABIN1043890 : Jansen, Camalier, Colburn: Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis. in Cancer research 2005 (PubMed)
    Show all 2 Pubmed References

  5. Cow (Bovine) Polyclonal PDCD4 Primary Antibody for WB - ABIN2792230 : Yang, Cho, Zakowicz, Hegamyer, Sonenberg, Colburn: A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. in Molecular and cellular biology 2004 (PubMed)
    Show all 3 Pubmed References

  6. Human Polyclonal PDCD4 Primary Antibody for IF (p), IHC (p) - ABIN731993 : Yuan, Han, Cong, Ge, Ma, Dai, Li, Bi: Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity. in International journal of nanomedicine 2014 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal PDCD4 Primary Antibody for IP, IHC - ABIN129709 : Santhanam, Baker, Hegamyer, Kirschmann, Colburn: Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion. in Oncogene 2010 (PubMed)
    Show all 2 Pubmed References

  8. Human Monoclonal PDCD4 Primary Antibody for IHC, ELISA - ABIN1043728 : Huang, Wu, Loeb, Hsu, Heidersbach, Brincat, Horiuchi, Lebbink, Mo, Goga, McManus: Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 Pubmed References

  9. Human Polyclonal PDCD4 Primary Antibody for ELISA, WB - ABIN129708 : Eto, Goto, Nakashima, Ura, Abe: Loss of programmed cell death 4 induces apoptosis by promoting the translation of procaspase-3 mRNA. in Cell death and differentiation 2011 (PubMed)

More Antibodies against PDCD4 Interaction Partners

Human Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. PDCD4 is expressed in the cytoplasm of glandular epithelium of control endometrium and varied during the cycle changes of endometrium. Compared with the proliferative phase of control endometrium, PDCD4 expression was down-regulated in proliferative phase of eutopic or ectopic endometrium. There was no cyclic variation of PDCD4 expression in eutopic endometrium of adenomyosis patients due to progesterone resistance.

  2. Study confirmed that PDCD4 was downregulated in non-small cell lung cancer (NSCLC). PDCD4 is a functional target for miR (show MLXIP Antibodies)-155 at both transcriptional and post-transcriptional levels.

  3. We demonstrated that miR (show MLXIP Antibodies)-208a-3p suppressed apoptosis in gastric cancer cells by targeting PDCD4.

  4. PDCD4 is involved in negative control of stromal fibroblasts conversion into cancer associated fibroblast

  5. Results identify PDCD4 as a novel RSK (show RPS6KA1 Antibodies) substrate. Authors demonstrate that RSK (show RPS6KA1 Antibodies)-mediated phosphorylation of PDCD4 at S76 promotes PDCD4 degradation.

  6. evaluate the relative expression levels of miR (show MLXIP Antibodies)-196a2 and three of its selected apoptosis-related targets; ANXA1 (show ANXA1 Antibodies), DFFA (show DFFA Antibodies) and PDCD4 in a sample of GI cancer patients

  7. In colorectal cancer tissues, the Sin1 (show MAPKAP1 Antibodies) protein but not mRNA was significantly upregulated while Pdcd4 protein was downregulated, suggesting that loss of Pdcd4 might correlate with Sin1 (show MAPKAP1 Antibodies) protein level but not mRNA level in colorectal cancer.

  8. miRNA-96 is significantly overexpressed in glioma tissues. Moreover, miRNA-96 plays a critical role in apoptosis by inhibiting the expression of PDCD4 in glioma.

  9. Supporting the clinical relevance of our results, we found an inverse correlation between ErbB-2 (show ERBB2 Antibodies)/Stat3 (show STAT3 Antibodies) nuclear co-expression and PDCD4 expression in ErbB-2 (show ERBB2 Antibodies)-positive primary invasive breast cancer

  10. this study highlights an oncomiR role for miR (show MLXIP Antibodies)-181b in regulating PDCD4 in colorectal cancer and suggests that miR (show MLXIP Antibodies)-181b may be a novel molecular therapeutic target for colorectal cancer.

Mouse (Murine) Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. In colorectal cancer tissues, the Sin1 (show MAPKAP1 Antibodies) protein but not mRNA was significantly upregulated while Pdcd4 protein was downregulated, suggesting that loss of Pdcd4 might correlate with Sin1 (show MAPKAP1 Antibodies) protein level but not mRNA level in colorectal cancer.

  2. -induced expression of PDCD4 is associated with increased beta cell death.

  3. miR (show MLXIP Antibodies)-155 not only directly inhibited SOCS1 (show SOCS1 Antibodies) expression, but also increased the expression of p-STAT (show STAT1 Antibodies) and PDCD4, as well as the production of proinflammation mediators IL-6 (show IL6 Antibodies) and TNF-alpha (show TNF Antibodies) in atherogenesis

  4. our data suggest that Pdcd4 as a crucial regulator in SGs (show SKI Antibodies) induced by ox-LDL or HFD maybe a potential target for mitigating SG-associated stress responses in obesity and related diseases.

  5. Pdcd4 deficiency attenuates atherosclerosis in hyperlipidemic mice in part through the upregulation of the anti-inflammatory cytokine IL-10 (show IL10 Antibodies).

  6. PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6 (show IL6 Antibodies)/STAT3 (show STAT3 Antibodies) Pathway.

  7. Study found that miR-16 (show GDE1 Antibodies) was the direct regulatory element of PDCD4 and played a vital role in atherosclerosis by regulating PDCD4 and the downstream NF-kappaB (show NFKB1 Antibodies) and MAPK (show MAPK1 Antibodies) pathways.

  8. Pdcd4 produces unfavorable influences on adipose-derived stem cells(ADSC) stemness, which contribute to adipose dysfunction, obesity and metabolic syndromes, thereby proposing Pdcd4 as a potential intervening target for regulating ADSC cells function.

  9. PDCD4 serves as an important regulator of keratinocytes proliferation and contact inhibition in vitro.

  10. In conclusion, miR (show MLXIP Antibodies)-21 is sensitive to high-concentration glucose treatment in macrophages, and appears to have a protective effect in macrophage apoptosis induced by high concentrations of glucose via PDCD4.

Zebrafish Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. miR (show MYLIP Antibodies)-21 plays a necessary role in cardiac valvulogenesis, in large part due to an obligatory downregulation of PDCD4

Pig (Porcine) Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-kappaB (show NFKB1 Antibodies)/ TNF-alpha (show TNF Antibodies) pathway in cardiomyocytes.

PDCD4 Antigen Profile

Protein Summary

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with PDCD4

  • programmed cell death 4 (PDCD4) antibody
  • programmed cell death 4 (Pdcd4) antibody
  • programmed cell death 4b (pdcd4b) antibody
  • programmed cell death 4 L homeolog (pdcd4.L) antibody
  • programmed cell death 4 (neoplastic transformation inhibitor) (PDCD4) antibody
  • programmed cell death 4 (pdcd4) antibody
  • cb45 antibody
  • D19Ucla1 antibody
  • Dug antibody
  • h731 antibody
  • Ma3 antibody
  • MGC69337 antibody
  • PDCD4 antibody
  • sb:cb45 antibody
  • Tis antibody
  • wu:fc84b08 antibody

Protein level used designations for PDCD4

neoplastic transformation inhibitor protein , nuclear antigen H731 , programmed cell death protein 4 , protein 197/15a , protein MA-3 , topoisomerase-inhibitor suppressed protein , death up-regulated gene protein , death-upregulated , protein I11/6 , programmed cell death 4 (neoplastic transformation inhibitor) , programmed cell death protein 4-like

GENE ID SPECIES
27250 Homo sapiens
18569 Mus musculus
64031 Rattus norvegicus
321061 Danio rerio
380222 Xenopus laevis
506724 Bos taurus
374191 Gallus gallus
407925 Xenopus (Silurana) tropicalis
450735 Pan troglodytes
477818 Canis lupus familiaris
695345 Macaca mulatta
100021762 Monodelphis domestica
100080517 Ornithorhynchus anatinus
100354557 Oryctolagus cuniculus
100413000 Callithrix jacchus
100469480 Ailuropoda melanoleuca
100584426 Nomascus leucogenys
100157112 Sus scrofa
100173014 Pongo abelii
100723476 Cavia porcellus
Selected quality suppliers for anti-PDCD4 (PDCD4) Antibodies
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