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This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. Additionally we are shipping PTGS1 Antibodies (161) and PTGS1 Kits (68) and many more products for this protein.
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This study showed that COX-1 and COX-2 (show PTGS2 Proteins) in genital carcinomas in the horse is poor; microsomal PGES (show PTGES Proteins)-1 is more prominently expressed.
COX-1 and COX-2 (show PTGS2 Proteins) genes were constitutively expressed in baseline samples. Low-flow ischemia resulted in significant upregulation of COX-2 (show PTGS2 Proteins) gene expression at each subsequent time point, compared with baseline values.
In this study, both COX-1 and COX-2 (show PTGS2 Proteins) were expressed in the colon before induced ischemia; ischemic injury increased expression of COX-2 (show PTGS2 Proteins).
Immunoreactivity for COX-1 and COX-2 (show PTGS2 Proteins) is high in equine corneal SCC (show CYP11A1 Proteins), possibly indicating that COX (show CPOX Proteins) plays a role in oncogenesis or progression of this tumor type at this site.
These results suggest that licochalcones inhibit collagen-induced platelet aggregation accompanied by inhibition of COX-1 activity.
Data suggest that Il4 (show IL4 Proteins) (usually released from helper T-cells) induces Cox1 in macrophages at post-transcriptional level; activation of Ampk (show PRKAA1 Proteins) (catalytic subunit Prkaa1 (show PRKAA1 Proteins)) by metformin blocks Il4 (show IL4 Proteins)-dependent induction of Cox1 and blocks macrophage polarization/activation. (Il4 (show IL4 Proteins) = interleukin-4 (show IL4 Proteins); Cox1 = cyclooxygenase 1; Ampk (show PRKAA1 Proteins) = AMP-activated protein kinase (show PRKAA2 Proteins))
Specific inhibition of PGE2 synthesis by targeting mPGES-1 (show PTGES Proteins) may weaken host defense against bacterial infections.
Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2 (show YWHAZ Proteins), lipoxygenase and cyclooxygenase.
role of cyclooxygenase-1 and -2 in endothelium-dependent contraction of atherosclerotic mouse abdominal aortas
Suggest the expression of COX-1 and COX-2 in the urothelium protects bladder damage from radiation.
COX-1 inhibitor SC-560 has a protective effect on the thromboxane A2-mediated decrease in renal function in response to endotoxin.
Expression of COX-1 is essential for the protection of liver against chemical-induced hepatotoxicity and required for hepatic homeostatic maintenance.
Data suggest that multitarget FAAH (show FAAH Proteins)/Cox (show CPOX Proteins) blockade may provide a transformative approach to inflammatory bowel disease (IBD) and other pathologies in which fatty acid amide hydrolase (show FAAH Proteins)/cyclooxygenases (FAAH (show FAAH Proteins), Cox-1, and Cox-2) are overactive.
In arteries from non-insulin (show INS Proteins)-dependent diabetic mice, COX-1 remains a major contributor to the endothelial PGI2 (show PTGIR Proteins) synthesis that evokes vasoconstrictor activity under the pathological condition.
specific inhibition of mmu-miR (show MLXIP Proteins)-100-5p significantly enhanced expression of Il6 (show IL6 Proteins), Ptgs1/2 and Tlr4 (show TLR4 Proteins) mRNA
there was no expression of COX-1, either mRNA or protein, on any day of the estrous cycle
Panax quinquefolium saponin attenuated HUVEC apoptosis and improved the dual antiplatelet-mediated reduction of platelet adhesion to injured HUVECs and the underlying mechanisms may be associated with PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) and COX (show COX8A Proteins) pathways.
The interactions of COX (show COX8A Proteins)-1of rs3842787 and cox-2 of rs20417 were associated with aspirin resistance of stroke.
We provide the first report that pro-angiogenic genes PECAM1 (show PECAM1 Proteins), PTGS1, FGD5 (show FGD5 Proteins), and MCAM (show MCAM Proteins) may play a vital role in pathological dermal angiogenesis disorders of psoriasis.
a new neutrophil-activating platelet-derived lipid generated by COX-1 is presented that can activate or prime human neutrophils, suggesting a role in innate immunity and acute inflammation.
Seminal COX-1 is over-expressed in infertile oligoasthenoteratozoospermic (OAT (show OAT Proteins)) men with varicocele (Vx) compared with fertile men with/without and infertile OAT (show OAT Proteins) men without Vx being associated with oxidative stress, Vx grade and Vx laterality.
In Indian peptic ulcer hemorrhage patients, those with Cox-1 A842G polymorphisms tended to have less gastric ulcers among those with the A842G/C50T polymorphism.
inverse allosteric regulation likely underlies the ability of PGHS-2 (show PTGS2 Proteins) to operate at low AA concentrations, when PGHS-1 is effectively latent.
PON1 (show PON1 Proteins), P2Y12 (show P2RY12 Proteins) and COX1 polymorphisms were associated with poorer vascular outcomes in patients with extracranial or intracranial stents.
The regulation of important oxylipin metabolic genes in peripheral blood mononuclear cells varied with the extent of change in arachidonic acid concentrations in the case of PTGS1 and ALOX12 (show ALOX12 Proteins) regulation.
Brain death increases the expression of COX-1 and COX-2 (show PTGS2 Proteins) mRNA in the renal medulla
Endometrial prostaglandin-endoperoxide synthase 1 (PTGS1) mRNA expression increased 2- to 3-fold after Day 10 of the estrous cycle and pregnancy, whereas PTGS2 (show PTGS2 Proteins) mRNA expression increased 76-fold between Days 5 and 15 of the estrous cycle and pregnancy.
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants.
, prostaglandin G/H synthase 1
, prostaglandin G/H synthase and cyclooxygenase
, prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
, PGH synthase 1
, PHS 1
, prostaglandin H2 synthase 1
, prostaglandin-endoperoxide synthase 1
, cyclooxygenase 1
, cyclooxygenase 3
, prostaglandin endoperoxide synthase