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Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. Additionally we are shipping RAE1 Antibodies (67) and and many more products for this protein.
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surface NKG2D (show KLRK1 Proteins) ligand RAE1epsilon (show RAET1E Proteins) on tumour cells induces CD11b (show ITGAM Proteins)(+) Gr-1 (show GSR Proteins)(+) myeloid-derived suppressor cell (MDSC) via NKG2D (show KLRK1 Proteins) in vitro and in vivo.
The authors observed that the mouse cytomegalovirus encoded protein m18 is necessary and sufficient to drive expression of the RAE-1 family of NKG2D (show KLRK1 Proteins) ligands. RAE-1 is transcriptionally repressed by histone deacetylase (show HDAC1 Proteins) inhibitor 3 (show PPP1R11 Proteins) (HDAC3 (show HDAC3 Proteins)) in healthy cells, and m18 relieves this repression by directly interacting with Casein Kinase II (show CSNK2A1 Proteins) and preventing it from activating HDAC3 (show HDAC3 Proteins).
High RAE1 expression is associated with lymphoma.
Viral infection of cultured cells increased RAE-1 expression, resulting in enhanced NK cell-mediated killing through NKG2D (show KLRK1 Proteins) recognition.
An increased expression of the NKG2D (show KLRK1 Proteins) ligand MICA (show MICA Proteins) in systemic lupus erthematosus (SLE) patients' kidneys and Rae-1 and Mult-1 (show ULBP1 Proteins) in various murine SLE models, is reported.
Desiccating stress-induced chemokine (show CCL1 Proteins) expression in the epithelium is dependent on upregulation of NKG2D (show KLRK1 Proteins)/RAE-1 and release of IFN-gamma (show IFNG Proteins) in experimental dry eye.
Highly target-specific liver NKT (show CTSL1 Proteins) cells selectively remove activated hepatic stellate cells through an NKG2D (show KLRK1 Proteins)-Rae1 interaction to ameliorate liver fibrosis after IL-30 treatment.
Results suggest that genomic damage in tumor cells leads to activation of STING-dependent DNA sensor pathways, thereby activating RAE1 and enabling tumor immunosurveillance.
GM-SCF (show KITLG Proteins), IL-21 (show IL21 Proteins) and Rae1 expression, alone or in combination, induces a cellular immune response against H22 tumor cells.
mouse cytomegalovirus m152/gp40 interaction with RAE1gamma structural analysis reveals a paradigm for MHC/MHC interaction in immune evasion
show that USP11 is associated with the mitotic spindle, does not regulate SAC inactivation, but controls ubiquitination of RAE1 at the mitotic spindle, hereby functionally modulating its interaction with Nuclear Mitotic Apparatus protein (NuMA).
Nuclear export inhibition by ORF10 of human herpesvirus 8 requires an interaction with an RNA export factor, Rae1.
After PSK (show TAOK2 Proteins) administration, INF (show GIF Proteins)-g production in CD8 (show CD8A Proteins)(+) T cells increased in mice with cells expressing neither Rae-1 nor H60, but did not change in mice implanted with cells expressing both Rae-1 and H60. We demonstrated that the expression of NKG2DLs affects tumor immunity and the efficacy of immuno therapy in tumor-bearing mouse model
Vesiculoviral matrix (M) protein (show MYOM2 Proteins) occupies nucleic acid binding site at nucleoporin (show AGFG2 Proteins) pair (Rae1 * Nup98 (show NUP98 Proteins)).
vesicular stomatitis virus M protein (show MYOM2 Proteins) interacted efficiently with Rae1-Nup98 (show NUP98 Proteins) complexes associated with the chromatin fraction of host nuclei, consistent with an effect on host transcription
This study established a novel postmitotic function for rae-1 in neuronal development.
RAE1 transgene orchestrates proper chromosome segregation and NUP98 (show NUP98 Proteins)-mediated leukemogenesis.
In a transgenic mouse model of chronic natural killer NKG2D (show KLRK1 Proteins) ligand expression, constant exposure to NKG2D (show KLRK1 Proteins) ligand RNA export 1 homolog (Rae-1 epsilon (show RAET1E Proteins)) does not functionally impair NK cells or CD8 (show CD8A Proteins)-positive T cells in the context of viral infection.
present the crystal structure of human Rae1 in complex with the Gle2-binding sequence (GLEBS) of Nup98 (show NUP98 Proteins) at 1.65 A resolution. Rae1 forms a seven-bladed beta-propeller with several extensive surface loops.
Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
mRNA export factor
, mRNA-associated protein mrnp 41
, rae1 protein homolog
, RAE1 (RNA export 1, S.pombe) homolog
, RAE1 RNA export 1 homolog
, homolog of yeast Rae1 (Bharathi) mRNA-associated protein of 41 kDa (Kraemer)
, mRNA export protein
, mRNA-associated protein MRNP 41
, mRNA-binding protein, 41-kD
, migration-inducing gene 14