Sirtuin 6 Proteins (SIRT6)

SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 6 Antibodies (218) and Sirtuin 6 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIRT6 50721 P59941
SIRT6 51548 Q8N6T7
SIRT6 299638  
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Top Sirtuin 6 Proteins at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$583.00
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 2 to 3 Days
$345.00
Details
Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
$720.00
Details
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$576.00
Details
Escherichia coli (E. coli) Human His tag   10 μg Log in to see 2 to 3 Days
$245.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$554.07
Details
Escherichia coli (E. coli) Human His tag   100 μg Log in to see 15 to 18 Days
$512.00
Details

SIRT6 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human , , , ,
, ,
Rat (Rattus)

Top referenced Sirtuin 6 Proteins

  1. Human SIRT6 Protein expressed in Wheat germ - ABIN1320053 : Palmer, Fullston, Mitchell, Setchell, Lane: SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity. in Reproduction, fertility, and development 2011 (PubMed)

More Proteins for Sirtuin 6 (SIRT6) Interaction Partners

Mouse (Murine) Sirtuin 6 (SIRT6) interaction partners

  1. Sirt6 inhibits Notch1 (show NOTCH1 Proteins) and Notch4 (show NOTCH4 Proteins) transcription by deacetylating histone H3K9.

  2. Sirt6 is downregulated in induced pluripotent stem cells from old mice.

  3. post-translational modification facilitates the mobilization of SIRT6 to DNA damage sites and is required for efficient recruitment of poly (ADP-ribose) polymerase 1 (PARP1 (show PARP1 Proteins)) to DNA break sites and for efficient repair of double-strand break.

  4. SIRT6 and its downstream signaling could be targeted in Alzheimer's disease and age-related neurodegeneration.

  5. These findings reveal a crucial role of SIRT6 in adipogenesis and provide potential therapeutic targets for obesity.

  6. Global and endothelium-specific SIRT6 knockout mice exhibited impaired endothelium-dependent vasorelaxation. Moreover, SIRT6(+/-) haploinsufficient mice fed a high-fat diet (HFD) also displayed impaired endothelium-dependent vasorelaxation. Importantly, SIRT6(+/-); ApoE(-/-) mice after HFD feeding had exacerbated atherosclerotic lesion development, concurrent with increased expression of proinflammatory cytokine VCAM-1.

  7. these data provide compelling evidence that Sirt6 is important for podocyte homeostasis and maintenance of glomerular function

  8. The mice with SIRT6 deficiency in muscle displayed impaired glucose homeostasis and insulin (show INS Proteins) sensitivity, attenuated whole body energy expenditure, and weakened exercise performance. Results from both gain- and loss-of-function experiments identify SIRT6 as a physiological regulator of muscle mitochondrial function.

  9. Study investigated the involvement of SIRT6 in adult hippocampal neurogenesis. Mice over-expressing Sirt6 exhibit increased numbers of young neurons and decreased numbers of mature neurons, without affecting glial differentiation.

  10. Sirt6 deletion in macrophages promoted the activation of nuclear factor-kappaB (NF-kappaB (show NFKB1 Proteins)) and endogenous production of interleukin-6 (show IL6 Proteins), which led to STAT3 (show STAT3 Proteins) activation and the positive feedback circuits for NF-kappaB (show NFKB1 Proteins) stimulation; this cross talk expedited an M1 polarization

Human Sirtuin 6 (SIRT6) interaction partners

  1. this study not only suggests potential roles of SIRT6 in regulating apoptosis and stress resistance via direct deacetylation of p53 (show TP53 Proteins), but also provides lead compound for the development of potent and selective SIRT6 inhibitors.

  2. in vitro and in vivo studies showed that gene silencing of SIRT6 suppressed cell proliferation and promoted cellular apoptosis by activating the Bax (show BAX Proteins)-dependent apoptotic signal pathway in Hepatocellular Carcinoma cells. Furthermore, SIRT6 knockdown could increase liver cancer cell sensitivity to chemotherapy drug doxorubicin. SIRT6 is an important protumorigenic factor in liver carcinogenesis.

  3. SIRT6 is upregulated in non-small cell lung cancer; it may have a functional role in promoting migration and invasion through ERK1/2/MMP9 (show MMP9 Proteins) signaling

  4. Sirt6 inhibits Notch1 (show NOTCH1 Proteins) and Notch4 (show NOTCH4 Proteins) transcription by deacetylating histone H3K9.

  5. These data provide the first evidence of the Egt ability to interfere with endothelial senescence linked to hyperglycaemia through the regulation of SIRT1 (show SIRT1 Proteins) and SIRT6 signaling, thus further strengthening the already assessed role of these two histone deacetylases in type 2 diabetes.

  6. Study shows that SIRT6 protein levels are lower in patients with prediabetes (PreDM) and type 2 diabetes mellitus (T2DM) and implies that SIRT6 may take play in development T2DM by altering the expression of genes involved in glucose metabolism through histone modification rather than its role in DNA repair.

  7. Low SIRT6 expression is associated with bone marrow metastasis in neuroblastoma (show ARHGEF16 Proteins).

  8. SIRT6 overexpression suppresses PI3K (show PIK3CA Proteins) signaling.

  9. post-translational modification facilitates the mobilization of SIRT6 to DNA damage sites and is required for efficient recruitment of poly (ADP-ribose) polymerase 1 (PARP1 (show PARP1 Proteins)) to DNA break sites and for efficient repair of double-strand break.

  10. SIRT6 and its downstream signaling could be targeted in Alzheimer's disease and age-related neurodegeneration.

Cow (Bovine) Sirtuin 6 (SIRT6) interaction partners

  1. results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (show MAS1 Proteins)) and management in beef cattle breeding programs.

Sirtuin 6 (SIRT6) Protein Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with Sirtuin 6 Proteins (SIRT6)

  • sirtuin 6 (Sirt6)
  • sirtuin 6 (SIRT6)
  • sirtuin 6 S homeolog (sirt6.S)
  • sirtuin 6 (sirt6)
  • 2810449N18Rik protein
  • AI043036 protein
  • SIR2L6 protein
  • zgc:86729 protein

Protein level used designations for Sirtuin 6 Proteins (SIRT6)

NAD-dependent deacetylase sirtuin-6 , NAD-dependent protein deacetylase sirtuin-6 , SIR2-like protein 6 , regulatory protein SIR2 homolog 6 , sir2-related protein type 6 , sirtuin type 6 , sirtuin (silent mating type information regulation 2 homolog) 6

GENE ID SPECIES
50721 Mus musculus
51548 Homo sapiens
299638 Rattus norvegicus
428332 Gallus gallus
535416 Bos taurus
100126274 Sus scrofa
444018 Xenopus laevis
485045 Canis lupus familiaris
100734667 Cavia porcellus
415161 Danio rerio
737026 Pan troglodytes
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