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SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 6 Antibodies (218) and Sirtuin 6 Kits (18) and many more products for this protein.
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Human SIRT6 Protein expressed in Wheat germ - ABIN1320053
Palmer, Fullston, Mitchell, Setchell, Lane: SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity. in Reproduction, fertility, and development 2011
Sirt6 inhibits Notch1 (show NOTCH1 Proteins) and Notch4 (show NOTCH4 Proteins) transcription by deacetylating histone H3K9.
Sirt6 is downregulated in induced pluripotent stem cells from old mice.
post-translational modification facilitates the mobilization of SIRT6 to DNA damage sites and is required for efficient recruitment of poly (ADP-ribose) polymerase 1 (PARP1 (show PARP1 Proteins)) to DNA break sites and for efficient repair of double-strand break.
SIRT6 and its downstream signaling could be targeted in Alzheimer's disease and age-related neurodegeneration.
These findings reveal a crucial role of SIRT6 in adipogenesis and provide potential therapeutic targets for obesity.
Global and endothelium-specific SIRT6 knockout mice exhibited impaired endothelium-dependent vasorelaxation. Moreover, SIRT6(+/-) haploinsufficient mice fed a high-fat diet (HFD) also displayed impaired endothelium-dependent vasorelaxation. Importantly, SIRT6(+/-); ApoE(-/-) mice after HFD feeding had exacerbated atherosclerotic lesion development, concurrent with increased expression of proinflammatory cytokine VCAM-1.
these data provide compelling evidence that Sirt6 is important for podocyte homeostasis and maintenance of glomerular function
The mice with SIRT6 deficiency in muscle displayed impaired glucose homeostasis and insulin (show INS Proteins) sensitivity, attenuated whole body energy expenditure, and weakened exercise performance. Results from both gain- and loss-of-function experiments identify SIRT6 as a physiological regulator of muscle mitochondrial function.
Study investigated the involvement of SIRT6 in adult hippocampal neurogenesis. Mice over-expressing Sirt6 exhibit increased numbers of young neurons and decreased numbers of mature neurons, without affecting glial differentiation.
Sirt6 deletion in macrophages promoted the activation of nuclear factor-kappaB (NF-kappaB (show NFKB1 Proteins)) and endogenous production of interleukin-6 (show IL6 Proteins), which led to STAT3 (show STAT3 Proteins) activation and the positive feedback circuits for NF-kappaB (show NFKB1 Proteins) stimulation; this cross talk expedited an M1 polarization
this study not only suggests potential roles of SIRT6 in regulating apoptosis and stress resistance via direct deacetylation of p53 (show TP53 Proteins), but also provides lead compound for the development of potent and selective SIRT6 inhibitors.
in vitro and in vivo studies showed that gene silencing of SIRT6 suppressed cell proliferation and promoted cellular apoptosis by activating the Bax (show BAX Proteins)-dependent apoptotic signal pathway in Hepatocellular Carcinoma cells. Furthermore, SIRT6 knockdown could increase liver cancer cell sensitivity to chemotherapy drug doxorubicin. SIRT6 is an important protumorigenic factor in liver carcinogenesis.
SIRT6 is upregulated in non-small cell lung cancer; it may have a functional role in promoting migration and invasion through ERK1/2/MMP9 (show MMP9 Proteins) signaling
These data provide the first evidence of the Egt ability to interfere with endothelial senescence linked to hyperglycaemia through the regulation of SIRT1 (show SIRT1 Proteins) and SIRT6 signaling, thus further strengthening the already assessed role of these two histone deacetylases in type 2 diabetes.
Study shows that SIRT6 protein levels are lower in patients with prediabetes (PreDM) and type 2 diabetes mellitus (T2DM) and implies that SIRT6 may take play in development T2DM by altering the expression of genes involved in glucose metabolism through histone modification rather than its role in DNA repair.
Low SIRT6 expression is associated with bone marrow metastasis in neuroblastoma (show ARHGEF16 Proteins).
SIRT6 overexpression suppresses PI3K (show PIK3CA Proteins) signaling.
results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (show MAS1 Proteins)) and management in beef cattle breeding programs.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.
NAD-dependent deacetylase sirtuin-6
, NAD-dependent protein deacetylase sirtuin-6
, SIR2-like protein 6
, regulatory protein SIR2 homolog 6
, sir2-related protein type 6
, sirtuin type 6
, sirtuin (silent mating type information regulation 2 homolog) 6