Transient Receptor Potential Cation Channel, Subfamily M, Member 2 Proteins (TRPM2)

The protein encoded by TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Additionally we are shipping TRPM2 Antibodies (96) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRPM2 7226 O94759
Rat TRPM2 TRPM2 294329  
TRPM2 28240  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top TRPM2 Proteins at antibodies-online.com

Showing 3 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 70 to 75 Days
$11,428.37
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details

TRPM2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human
,
Mouse (Murine) ,
,

More Proteins for Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) Interaction Partners

Human Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. TRPM2 (show CLU Proteins) overexpression in a PDAC cell line (PANC1) promoted cell proliferation, invasion and metastatic ability. TRPM2 (show CLU Proteins) represents a potential therapeutic target and prognostic marker for patients with PDAC.

  2. The expression of TRPM2 (show CLU Proteins)-AS was higher in most HCC (show FAM126A Proteins) tissues and was significantly correlated with tumor size, AJCC stage, tumor differentiation, and the prognosis of HCC (show FAM126A Proteins) patients. Interfering TRPM2 (show CLU Proteins)-AS expression using siRNA significantly inhibited cell proliferation and promoted cell apoptosis in two HCC (show FAM126A Proteins) cell lines.

  3. Results reveal a novel, potentially druggable signalling pathway for FFA-induced beta-cell death. The cascade involves NOX-2 (show CYBB Proteins)-dependent production of ROS (show ROS1 Proteins), activation of TRPM2 (show CLU Proteins) channels, rise in mitochondrial Zn(2+), Drp-1 (show CRMP1 Proteins) recruitment and abnormal mitochondrial fission.

  4. TRPM2 (show CLU Proteins) is essential for the survival and migration of squamous cell cancer cells.

  5. Results provide compelling evidence to support a role for nitrosative stress in linking the TRPM2 (show CLU Proteins) turnover with the disturbance of autophagy in brain pericyte injury.

  6. oxidative stress activates the TRPM2 (show CLU Proteins)-Ca(2 (show CA2 Proteins)+)-CAMK2 (show CAMK2B Proteins) cascade to phosphorylate BECN1 (show BECN1 Proteins) resulting in autophagy inhibition

  7. We conclude from these studies that inhibition of ROS (show ROS1 Proteins) production, and the subsequent abrogation of TRPM2 (show CLU Proteins)-mediated Ca(2 (show CA2 Proteins)+) influx, is the primary mechanism underlying RE-1's inhibitory effect on LNs-induced inflammasome activation.

  8. oxidative stress activated the TRPM2 (show CLU Proteins)-CaMKII (show CAMK2G Proteins) cascade to further induce intracellular ROS (show ROS1 Proteins) production, which led to mitochondria fragmentation and loss of mitochondrial membrane potential

  9. The work summarized here shows that TRPM2 (show CLU Proteins) channels protect cardiac myocytes from ischaemia-reperfusion injury and tumour cells from doxorubicin toxicity, and demonstrates that the mechanisms involve preservation of mitochondrial bioenergetics and modulation of ROS (show ROS1 Proteins)

  10. Activation of TRPM2 (show CLU Proteins) channels, however, caused intracellular release of not only Ca(2 (show CA2 Proteins)+) but also of Zn(2+) Intriguingly, elevation of intracellular Zn(2+) faithfully reproduced all of the effects of H2O2, whereas Ca(2 (show CA2 Proteins)+) showed opposite effects. Interestingly, H2O2 caused increased trafficking of Zn(2+)-enriched lysosomes to the leading edge of migrating cells, presumably to impart polarisation of Zn(2+) location.

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. Results demonstrate a critical role for the TRPM2 channel in Abeta42-induced microglial activation and generation of TNF-alpha (show TNF Proteins): PKC/NOX-mediated generation of ROS (show ROS1 Proteins) and activation of PARP-1 (show PARP1 Proteins) are required for Abeta42-induced TRPM2 channel activation and, furthermore, the PYK2 (show PTK2B Proteins)/MEK (show MDK Proteins)/ERK (show EPHB2 Proteins) signaling pathway as a positive feedback mechanism downstream of TRPM2 channel activation facilitates further activation of PARP-1 (show PARP1 Proteins) and TRPM2 ...

  2. Results reveal a novel, potentially druggable signalling pathway for FFA-induced beta-cell death. The cascade involves NOX-2 (show CYBB Proteins)-dependent production of ROS (show ROS1 Proteins), activation of TRPM2 channels, rise in mitochondrial Zn(2+), Drp-1 (show CRMP1 Proteins) recruitment and abnormal mitochondrial fission.

  3. High TRPM2 to trigger lysosomal membrane permeabilization and Zn(2+)-mediated mitochondrial fission.

  4. Trpm2 might promote hyperinflammation in Down Syndrome.

  5. Studied the role of transient receptor potential melastatin 2 (show TRPM3 Proteins) (TRPM2) in activating caspase-1 (show CASP1 Proteins) and caspase-1 (show CASP1 Proteins)-dependent pyroptosis in mouse BMDMs. Found TRPM2 knockout caused higher caspase-1 (show CASP1 Proteins) activation and pyrotopsis.

  6. Transient receptor potential melastatin-2 (TRPM2) in pituitary nerve terminals plays a role in oxytocin release. Temperature- enhanced oxytocin release by CD38 and TRPM2. TRPM2 might be involved in the process of CD38-regulated oxytocin release.

  7. this study shows that TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection

  8. Overexpression of TRPM2 channel prevented neutrophil transendothelial migration and vascular injury.

  9. These findings of this study suggest that TRPM2 channels play an essential role in mediating hypoxic-ischemic brain injury in neonatal mice.

  10. TRPM2 regulates phagosomal acidification, and is essential for the bacterial killing function of macrophages.

Pig (Porcine) Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. Study determined the sequence of pig TRPC1 and TRPC3-7 channels and found pig TRPC cDNAs resemble their human homologs more than the others .

  2. heteromeric cation channels comprised of the TRPP2 mutant and the TRPC3 (show TRPC3 Proteins) or TRPC7 protein induce enhanced receptor-activated Ca(2 (show CA2 Proteins)+) influx that may lead to dysregulated cell growth in ADPKD

TRPM2 Protein Profile

Protein Summary

The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Gene names and symbols associated with TRPM2

  • transient receptor potential cation channel subfamily M member 2 (TRPM2)
  • transient receptor potential cation channel, subfamily M, member 2 (Trpm2)
  • transient receptor potential cation channel subfamily C member 6 (TRPC6)
  • transient receptor potential cation channel, subfamily M, member 2 (trpm2)
  • transient receptor potential cation channel subfamily C member 7 (TRPC7)
  • short transient receptor potential channel 7 (LOC100443123)
  • short transient receptor potential channel 7 (LOC100539776)
  • transient receptor potential cation channel subfamily M member 2 (trpm2)
  • transient receptor potential cation channel subfamily M member 2 (Trpm2)
  • 9830168K16Rik protein
  • C79133 protein
  • EREG1 protein
  • KNP3 protein
  • LTRPC2 protein
  • NUDT9H protein
  • NUDT9L1 protein
  • si:ch73-263b18.1 protein
  • Trp7 protein
  • TRPC7 protein
  • TRPM2 protein
  • Trpm2-predicted protein
  • Trrp7 protein

Protein level used designations for TRPM2

LTrpC-2 , estrogen-responsive element-associated gene 1 protein , long transient receptor potential channel 2 , transient receptor potential cation channel subfamily M member 2 , transient receptor potential channel 7 , transient receptor potential melastatin family 2 , transient receptor potential cation channel, subfamily M, member 2 , transient receptor potential cation channel, subfamily C, member 7 , transient receptor potential cation channel, subfamily C, member 7-like , short transient receptor potential channel 7-like , transient receptor potential cation channel subfamily M member 2-like , transient receptor protein 7 , transient receptor potential channel subfamily C member 7

GENE ID SPECIES
7226 Homo sapiens
294329 Rattus norvegicus
424835 Gallus gallus
470101 Pan troglodytes
508029 Bos taurus
703611 Macaca mulatta
799412 Danio rerio
100056810 Equus caballus
100083361 Ornithorhynchus anatinus
100124999 Xenopus (Silurana) tropicalis
100341596 Oryctolagus cuniculus
100443123 Pongo abelii
100479298 Ailuropoda melanoleuca
100479364 Ailuropoda melanoleuca
100539776 Meleagris gallopavo
100556895 Anolis carolinensis
28240 Mus musculus
100271727 Sus scrofa
100720314 Cavia porcellus
Selected quality suppliers for TRPM2 Proteins (TRPM2)
Did you look for something else?