Transient Receptor Potential Cation Channel, Subfamily M, Member 2 Proteins (TRPM2)

The protein encoded by TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Additionally we are shipping TRPM2 Antibodies (96) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRPM2 7226 O94759
Rat TRPM2 TRPM2 294329  
TRPM2 28240  
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Top TRPM2 Proteins at antibodies-online.com

Showing 3 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 70 to 75 Days
$11,229.61
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details

TRPM2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human
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Mouse (Murine) ,
,

More Proteins for Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) Interaction Partners

Human Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. TRPM2 overexpression in a PDAC cell line (PANC1) promoted cell proliferation, invasion and metastatic ability. TRPM2 represents a potential therapeutic target and prognostic marker for patients with PDAC.

  2. The expression of TRPM2-AS was higher in most HCC tissues and was significantly correlated with tumor size, AJCC stage, tumor differentiation, and the prognosis of HCC patients. Interfering TRPM2-AS expression using siRNA significantly inhibited cell proliferation and promoted cell apoptosis in two HCC cell lines.

  3. Results reveal a novel, potentially druggable signalling pathway for FFA-induced beta-cell death. The cascade involves NOX-2-dependent production of ROS, activation of TRPM2 channels, rise in mitochondrial Zn(2+), Drp-1 recruitment and abnormal mitochondrial fission.

  4. TRPM2 is essential for the survival and migration of squamous cell cancer cells.

  5. Results provide compelling evidence to support a role for nitrosative stress in linking the TRPM2 turnover with the disturbance of autophagy in brain pericyte injury.

  6. oxidative stress activates the TRPM2-Ca(2+)-CAMK2 cascade to phosphorylate BECN1 resulting in autophagy inhibition

  7. We conclude from these studies that inhibition of ROS production, and the subsequent abrogation of TRPM2-mediated Ca(2+) influx, is the primary mechanism underlying RE-1's inhibitory effect on LNs-induced inflammasome activation.

  8. oxidative stress activated the TRPM2-CaMKII cascade to further induce intracellular ROS production, which led to mitochondria fragmentation and loss of mitochondrial membrane potential

  9. The work summarized here shows that TRPM2 channels protect cardiac myocytes from ischaemia-reperfusion injury and tumour cells from doxorubicin toxicity, and demonstrates that the mechanisms involve preservation of mitochondrial bioenergetics and modulation of ROS

  10. Activation of TRPM2 channels, however, caused intracellular release of not only Ca(2+) but also of Zn(2+) Intriguingly, elevation of intracellular Zn(2+) faithfully reproduced all of the effects of H2O2, whereas Ca(2+) showed opposite effects. Interestingly, H2O2 caused increased trafficking of Zn(2+)-enriched lysosomes to the leading edge of migrating cells, presumably to impart polarisation of Zn(2+) location.

  11. neutrophils sense reactive oxygen species via the TRPM2 channel to arrest migration at their target site.

  12. The inhibitory function of oxidant sensing by TRPM2 requires the oxidation of Cys549, which then induces TRMP2 binding to formyl peptide receptor 1 (FPR1) and subsequent FPR1 internalization and signaling inhibition

  13. findings demonstrate the important function of TRPM2 in modulation of cell survival through mitochondrial ROS, and the potential of targeted inhibition of TRPM2 as a therapeutic approach to reduce cellular bioenergetics, tumor growth, and enhance susceptibility to chemotherapeutic agents.

  14. Study demonstrate that PRL is necessary for the survival of (retinal pigment epithelium) RPE under normal and advancing age conditions and, identified SIRT2 and TRPM2 as molecular targets for the antioxidant and antiapoptotic actions of PRL in the RPE.

  15. TRPM2 has a role in the DNA damage response of T cell leukemia cells in a BCL-2 dependent manner

  16. Data show that HEK293 cells expressing low levels of receptor potential melastatin 2 (TRPM2) channel were more susceptible to silica nanoparticles (NPs) than those expressing high levels of TRPM2.

  17. This is expected to provide a basis for inhibiting TRPM2 for the improved treatment of breast cancer, which potentially includes treating breast tumors that are resistant to chemotherapy due to their evasion of apoptosis.

  18. In a transgenic mouse model of Alzheimer's disease, TRPM2 was involved in neuronal toxicity and memory impairment.

  19. These findings shed new light on the evolution of TRPM2 and establish nvTRPM2 as a promising tool to decipher its complex gating mechanisms.

  20. we report here a novel effect promoted by TRPM2, where it functions to minimize DNA damage and thus may have a role in the protection of genomic DNA in breast cancer cells.

TRPM2 Protein Profile

Protein Summary

The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Gene names and symbols associated with TRPM2

  • transient receptor potential cation channel subfamily M member 2 (TRPM2)
  • transient receptor potential cation channel, subfamily M, member 2 (Trpm2)
  • transient receptor potential cation channel, subfamily M, member 2 (trpm2)
  • transient receptor potential cation channel subfamily C member 7 (TRPC7)
  • transient receptor potential cation channel subfamily M member 2 (trpm2)
  • transient receptor potential cation channel subfamily M member 2 (Trpm2)
  • 9830168K16Rik protein
  • C79133 protein
  • EREG1 protein
  • KNP3 protein
  • LTRPC2 protein
  • NUDT9H protein
  • NUDT9L1 protein
  • si:ch73-263b18.1 protein
  • Trp7 protein
  • TRPC7 protein
  • TRPM2 protein
  • Trpm2-predicted protein
  • Trrp7 protein

Protein level used designations for TRPM2

LTrpC-2 , estrogen-responsive element-associated gene 1 protein , long transient receptor potential channel 2 , transient receptor potential cation channel subfamily M member 2 , transient receptor potential channel 7 , transient receptor potential melastatin family 2 , transient receptor potential cation channel, subfamily M, member 2 , transient receptor potential cation channel, subfamily C, member 7 , transient receptor potential cation channel, subfamily C, member 7-like , transient receptor potential cation channel subfamily M member 2-like , transient receptor protein 7

GENE ID SPECIES
7226 Homo sapiens
294329 Rattus norvegicus
424835 Gallus gallus
470101 Pan troglodytes
508029 Bos taurus
799412 Danio rerio
100056810 Equus caballus
100083361 Ornithorhynchus anatinus
100124999 Xenopus (Silurana) tropicalis
100341596 Oryctolagus cuniculus
100479364 Ailuropoda melanoleuca
100556895 Anolis carolinensis
28240 Mus musculus
100720314 Cavia porcellus
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