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UPF1 encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. Additionally we are shipping UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) Proteins (4) and and many more products for this protein.
Showing 10 out of 73 products:
Human Polyclonal UPF1 Primary Antibody for WB - ABIN151832
Silva, Pereira, Morgado, Kong, Martins, Faustino, Liebhaber, Romão: The canonical UPF1-dependent nonsense-mediated mRNA decay is inhibited in transcripts carrying a short open reading frame independent of sequence context. in RNA (New York, N.Y.) 2006
Show all 9 Pubmed References
Human Polyclonal UPF1 Primary Antibody for WB - ABIN1882125
Mendell, ap Rhys, Dietz: Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts. in Science (New York, N.Y.) 2002
Show all 6 Pubmed References
Human Polyclonal UPF1 Primary Antibody for IP, PLA - ABIN438392
Martins, Proença, Silva, Barbosa, Silva, Faustino, Romão: Alternative polyadenylation and nonsense-mediated decay coordinately regulate the human HFE mRNA levels. in PLoS ONE 2012
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Human Polyclonal UPF1 Primary Antibody for WB - ABIN151833
Silva, Ribeiro, Inácio, Liebhaber, Romão: Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay. in RNA (New York, N.Y.) 2008
Human Polyclonal UPF1 Primary Antibody for WB - ABIN388607
Ohnishi, Yamashita, Kashima, Schell, Anders, Grimson, Hachiya, Hentze, Anderson, Ohno: Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. in Molecular cell 2003
Show all 3 Pubmed References
Human Polyclonal UPF1 Primary Antibody for PLA, WB - ABIN151834
Luke, Azzalin, Hug, Deplazes, Peter, Lingner: Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay. in Nucleic acids research 2008
Human Polyclonal UPF1 Primary Antibody for WB - ABIN6243988
Tian, Macdonald et al.: The intronic GABRG2 mutation, IVS6+2T->G, associated with childhood absence epilepsy altered subunit mRNA intron splicing, activated nonsense-mediated decay, and produced a stable truncated γ2 ... in The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Status epilepticus led to increased protein levels of Up-frameshift suppressor 1 homolog (Upf1) within the mouse hippocampus. Upf1 protein levels were also higher in resected hippocampus from patients with intractable temporal lobe epilepsy.
UPF1 is amplified by hyperphosphorylation which reduces stalls in nonsense-mediated RNA decay
UPF1 interacts with PNRC2 (show PNRC2 Antibodies) and that it triggers 5'-3' exonucleolytic decay of reporter transcripts in tethering assays.
UPF1 regulates the expression of genes with functions in inflammation and myeloid cell differentiation via hnRNP E2 (show PCBP2 Antibodies).
HTLV-1 Tax (show CNTN2 Antibodies) protein interacts with the central helicase core domain of UPF1 and freezes it, which leads to nonsense-mediated mRNA decay inhibition.
results indicate that UPF1 can dissociate miRNAs from their mRNA targets, making the miRNAs susceptible to Tudor-staphylococcal/micrococcal-like nuclease (show DCLRE1C Antibodies) (TSN (show TSN Antibodies))-mediated miRNA decay.
Overexpression of UPF1 inhibited cell proliferation, cell cycle progression, cell migration and invasion, and promoted cell apoptosis in gastric cancer cells. Moreover, the UPF1-mediated inhibition of gastric cancer progression was reversed by overexpression of MALAT1.
The nucleic acids processing activities of UPF1 are consistent with its function in mRNA regulation and suggest that roles in DNA replication could also be influenced by base sequence.
MARVELD1 (show MARVELD1 Antibodies) substantially inhibits nonsense-mediated RNA decay by decreasing the pioneer round of translation but not steady-state translation, and is an important component of the molecular machinery containing UPF1 and Y14 (show RBM8A Antibodies). MARVELD1 (show MARVELD1 Antibodies) promotes the dissociation of SMG1 (show SMG1 Antibodies) from UPF1, resulting in the repression of serine phosphorylation of UPF1, and subsequently blocks the recruitment of SMG5 (show SMG5 Antibodies).
UPF1 acts as an E3 ligase via its RING domain to promote MYOD protein ubiquitination and degradation and repress myogenesis.
Downregulation of UPF1 activated the TNFR1 (show TNFRSF1A Antibodies)-dependent NF-kappaB (show NFKB1 Antibodies)/MAPKs pathway, and promoting inflammatory responses in colon might act as a causal role in Ulcerative Colitis.
Upon removal of TDRD6, the association of several mRNAs with UPF1 and UPF2 is disturbed, and the long 3' UTR-stimulated but not the downstream exon-exon junction triggered pathway of NMD is impaired.This function depends on TDRD6-promoted assembly of mRNA and decay enzymes in Chromatoid bodies .
results identify novel nonsense-mediated mRNA decay (NMD) determinants and targets and provide context for understanding the impact of UPF1 and NMD on the murine embryonic stem cell transcriptome
results suggest that the role of SMG-5 (show ZCCHC11 Antibodies) is to direct protein phosphatase 2A to its SMG-2 substrate
SMG-2 interacts with SMG-3 (show UPF2 Antibodies), SMG-3 (show UPF2 Antibodies) interacts with SMG-4, and SMG-2 interacts indirectly with SMG-4 via shared interactions with SMG-3 (show UPF2 Antibodies). SMG-2 preferentially associates with PTC (show PTCH1 Antibodies)-containing mRNAs.
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.
ATP-dependent helicase RENT1
, UP Frameshift 1
, delta helicase
, nonsense mRNA reducing factor 1
, regulator of nonsense transcripts 1
, smg-2 homolog, nonsense mediated mRNA decay factor
, up-frameshift mutation 1 homolog
, up-frameshift suppressor 1 homolog
, yeast Upf1p homolog
, Regulator of nonsense transcripts 1 (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog)
, LOW QUALITY PROTEIN: regulator of nonsense transcripts 1
, UPF1 regulator of nonsense transcripts homolog S homeolog