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The protein encoded by UBA1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. Additionally we are shipping UBA1 Kits (11) and UBA1 Proteins (11) and many more products for this protein.
Showing 10 out of 108 products:
Cow (Bovine) Polyclonal UBA1 Primary Antibody for WB - ABIN2774233
Ramser, Ahearn, Lenski, Yariz, Hellebrand, von Rhein, Clark, Schmutzler, Lichtner, Hoffman, Meindl, Baumbach-Reardon: Rare missense and synonymous variants in UBE1 are associated with X-linked infantile spinal muscular atrophy. in American journal of human genetics 2008
Show all 2 Pubmed References
Human Polyclonal UBA1 Primary Antibody for IHC (p), WB - ABIN658476
Carbia-Nagashima, Gerez, Perez-Castro, Paez-Pereda, Silberstein, Stalla, Holsboer, Arzt: RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. in Cell 2007
Show all 3 Pubmed References
Human Polyclonal UBA1 Primary Antibody for IHC (p), IHC - ABIN269734
Panigrahi, Zhang, Otta, Pati: A cohesin-RAD21 interactome. in The Biochemical journal 2012
Polyubiquitination and proteasomal degradation of ezrin (show EZR Antibodies) and CUGBP1 (show CELF1 Antibodies) require Uba6 (show UBA6 Antibodies), but not Uba1, and that Uba6 (show UBA6 Antibodies) is involved in the control of ezrin (show EZR Antibodies) localization and epithelial morphogenesis. These data suggest that distinctive substrate pools exist for Uba1 and Uba6 (show UBA6 Antibodies) that reflect non-redundant biological roles for Uba6 (show UBA6 Antibodies).
Results from a study on gene expression variability markers in early-stage human embryos shows that UBA1 is a putative expression variability marker for the 3-day, 8-cell embryo stage.
recent findings put UBA1 at the center of cellular homeostasis and neurodegeneration [review]
A ubiquitin shuttle DC-UbP reconciles protein ubiquitination and deubiquitination via linking UbE1 and USP5 (show USP5 Antibodies) enzymes.
Conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 (show UBD Antibodies) targets it for proteasomal degradation
Ubiquitin-activating enzyme is necessary for 17beta-estradiol-induced breast cancer cell proliferation and migration.
Diminished ubiquitylation phenotype observed in enteropathogenic Escherichia coli infected cells corresponds to a strong reduction in the abundance of both Ube1 and Uba6 (show UBA6 Antibodies).
Decrease in free ubiquitin levels under stress allows NEDD8 (show NEDD8 Antibodies) to be conjugated through Ube1.
UBA1 knockdown impairs formation of ubiquitin conjugates at DNA double-strand breaks.
Data show that largazole and ester/keto analogs inhibit ubiquitin E1 activation.
Inhibition of ubiquitin-activating enzyme E1 (Ube1) increases the levels of high- molecular weight mouse Htt (show HTT Antibodies) in relatively unaffected tissues, declining in the nuclear fraction with age.
Dysregulation of UBA1 and subsequent ubiquitination pathways led to beta-catenin (show CTNNB1 Antibodies) accumulation in a model of spinal muscular atrophy.
These data suggest that Cys (show DNAJC5 Antibodies)-278 can affect Ub charging through a change in the structural conformation of UBA1, not through direct interaction at the UBA1-Ub interface.
biochemical and crystallographic characterization of the two half-domains and the crystal structure of the larger, second catalytic cysteine half-domain of mouse ubiquitin-activating enzyme
The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described.
A1S9T and BN75 temperature sensitivity complementing
, POC20 centriolar protein homolog
, UBA1, ubiquitin-activating enzyme E1 homolog A
, ubiquitin-like modifier-activating enzyme 1
, Ubiquitin-conjugating enzyme E1
, ubiquitin-activating enzyme E1, Chr X
, ubiquitin-activating enzyme E1
, ubiquitin activating enzyme
, ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing)
, Poly(A)+ RNA transport protein 3