anti-Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1) Antibodies

The protein encoded by UBA1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. Additionally we are shipping UBA1 Kits (10) and UBA1 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
UBA1 7317 P22314
UBA1 22201 Q02053
UBA1 314432 Q5U300
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Top anti-UBA1 Antibodies at antibodies-online.com

Showing 10 out of 113 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-UBA1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of UBA1 expression in rat liver extract (lane 1), mouse liver extract (lane 2), mouse testis extract (lane 3) and HELA whole cell lysates (lane 4). UBA1 at 117KD was detected using rabbit anti- UBA1 Antigen Affinity purified polyclonal antibody at0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC (p), WB UBA1 Antibody (N-term) (ABIN658476) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the UBA1 antibody detected the UBA1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Dog Rabbit Un-conjugated EIA, IHC (p), WB   0.5 mg Log in to see 4 to 8 Days
$715.00
Details
Human Rabbit Un-conjugated IHC (p), IHC, ELISA, WB 0.25 mg Log in to see 7 to 9 Days
$559.35
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see Available
$181.73
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: Ubiquitin-activating Enzyme/UBE1 Antibody  - Analysis in human cell line HEK 293. Immunohistochemistry-Paraffin: Ubiquitin-activating Enzyme/UBE1 Antibody  - Staining of human cerebral cortex shows distinct nuclear positivity in glial cells. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Mouse Un-conjugated ELISA, IP, WB Human UBE1 / UBA1 Western blot (WB) 14049 100 μg Log in to see 14 to 16 Days
$247.82
Details
Human Rabbit Un-conjugated FACS, ICC, IF, IHC, IHC (p), WB Flow Cytometry: Ubiquitin-activating Enzyme/UBE1 Antibody (SD08-62)  - Analysis of K562 cells with UBA1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. Immunocytochemistry/Immunofluorescence: Ubiquitin-activating Enzyme/UBE1 Antibody (SD08-62)  - Staining UBA1 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 100 μL Log in to see 34 Days
$375.73
Details

Top referenced anti-UBA1 Antibodies

  1. Polyclonal UBA1 Primary Antibody for IHC (p), ELISA - ABIN539510 : Brès, Kiernan, Linares, Chable-Bessia, Plechakova, Tréand, Emiliani, Peloponese, Jeang, Coux, Scheffner, Benkirane: A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter. in Nature cell biology 2003 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal UBA1 Primary Antibody for IHC (p), IHC - ABIN269734 : Panigrahi, Zhang, Otta, Pati: A cohesin-RAD21 interactome. in The Biochemical journal 2012 (PubMed)

  3. Cow (Bovine) Polyclonal UBA1 Primary Antibody for WB - ABIN2774233 : Ramser, Ahearn, Lenski, Yariz, Hellebrand, von Rhein, Clark, Schmutzler, Lichtner, Hoffman, Meindl, Baumbach-Reardon: Rare missense and synonymous variants in UBE1 are associated with X-linked infantile spinal muscular atrophy. in American journal of human genetics 2008 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal UBA1 Primary Antibody for IHC (p), WB - ABIN658476 : Carbia-Nagashima, Gerez, Perez-Castro, Paez-Pereda, Silberstein, Stalla, Holsboer, Arzt: RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. in Cell 2007 (PubMed)
    Show all 3 Pubmed References

More Antibodies against UBA1 Interaction Partners

Human Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1) interaction partners

  1. Polyubiquitination and proteasomal degradation of ezrin and CUGBP1 require Uba6, but not Uba1, and that Uba6 is involved in the control of ezrin localization and epithelial morphogenesis. These data suggest that distinctive substrate pools exist for Uba1 and Uba6 that reflect non-redundant biological roles for Uba6.

  2. Results from a study on gene expression variability markers in early-stage human embryos shows that UBA1 is a putative expression variability marker for the 3-day, 8-cell embryo stage.

  3. recent findings put UBA1 at the center of cellular homeostasis and neurodegeneration [review]

  4. A ubiquitin shuttle DC-UbP reconciles protein ubiquitination and deubiquitination via linking UbE1 and USP5 enzymes.

  5. Conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 targets it for proteasomal degradation

  6. Ubiquitin-activating enzyme is necessary for 17beta-estradiol-induced breast cancer cell proliferation and migration.

  7. We expressed and purified the N-terminal domains of human E1 and determined their crystal structures, which contain inactive adenylation domain (IAD) and the first catalytic cysteine half-domain (FCCH)

  8. Diminished ubiquitylation phenotype observed in enteropathogenic Escherichia coli infected cells corresponds to a strong reduction in the abundance of both Ube1 and Uba6.

  9. Decrease in free ubiquitin levels under stress allows NEDD8 to be conjugated through Ube1.

  10. UBA1 knockdown impairs formation of ubiquitin conjugates at DNA double-strand breaks.

  11. Data show that largazole and ester/keto analogs inhibit ubiquitin E1 activation.

  12. Ubiquitin and UBE1 are upregulated in tic epilepsy.

  13. In conclusion, nUBE1L is a novel human E1 like gene highly expressed in adult testis, which plays key role in ubiquitin system, and accordingly influences spermatogenesis and male fertility.

  14. analysis of ATP.Mg2+ binding in the catalytic cycle of ubiquitin-activating enzyme

  15. unusual type of regulation at the level of the E1 enzyme is likely to affect numerous cellular processes and may represent a strategy to coordinate multiple phenotypic changes upon differentiation by using E1 as a "master switch."

  16. Human Uba6 and Ube1 have distinct preferences for E2 charging in vitro, and their specificity depends in part on their C-terminal ubiquitin-fold domains, which recruit E2s

  17. Large-scale mutation analysis in genes resulted in detection of 3 rare novel variants in exon 15 of UBE1 that segregate with X-linked infantile spinal muscular atrophy.

  18. high-level expression of UBE1 was seen inextranodal NK/T cell lymphoma, nasal type; there was no significant difference between UBE1 expression and patients' outcome

Mouse (Murine) Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1) interaction partners

  1. Inhibition of ubiquitin-activating enzyme E1 (Ube1) increases the levels of high- molecular weight mouse Htt in relatively unaffected tissues, declining in the nuclear fraction with age.

  2. Dysregulation of UBA1 and subsequent ubiquitination pathways led to beta-catenin accumulation in a model of spinal muscular atrophy.

  3. These data suggest that Cys-278 can affect Ub charging through a change in the structural conformation of UBA1, not through direct interaction at the UBA1-Ub interface.

  4. biochemical and crystallographic characterization of the two half-domains and the crystal structure of the larger, second catalytic cysteine half-domain of mouse ubiquitin-activating enzyme

  5. E1 ligase of the proteasome is inhibitd by ziram and has a role in preventing dopaminergic cell damage

UBA1 Antigen Profile

Protein Summary

The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described.

Gene names and symbols associated with UBA1

  • ubiquitin like modifier activating enzyme 1 (UBA1) antibody
  • ubiquitin activating enzyme E1 (uae1) antibody
  • Ubiquitin-conjugating enzyme E1 (GL50803_4083) antibody
  • Ubiquitin-conjugating enzyme E1 (GL50803_10661) antibody
  • ubiquitin-like modifier activating enzyme 1 (Uba1) antibody
  • ubiquitin-like modifier activating enzyme 1 S homeolog (uba1.S) antibody
  • ubiquitin-like modifier activating enzyme 1 L homeolog (uba1.L) antibody
  • ubiquitin-like modifier activating enzyme 1 (uba1) antibody
  • ubiquitin activating enzyme E1 (ptr3) antibody
  • ubiquitin like modifier activating enzyme 1 (Uba1) antibody
  • a1s9 antibody
  • a1s9t antibody
  • a1st antibody
  • amcx1 antibody
  • DDBDRAFT_0190927 antibody
  • DDBDRAFT_0220497 antibody
  • DDB_0190927 antibody
  • DDB_0220497 antibody
  • gxp1 antibody
  • poc20 antibody
  • Sbx antibody
  • smax2 antibody
  • uba1 antibody
  • uba1a antibody
  • uba1b antibody
  • ube antibody
  • Ube-1 antibody
  • ube1 antibody
  • ube1x antibody
  • wu:fa01e08 antibody
  • wu:fb30f01 antibody
  • wu:fi21c11 antibody
  • wu:fj14g11 antibody
  • zgc:66143 antibody

Protein level used designations for UBA1

A1S9T and BN75 temperature sensitivity complementing , POC20 centriolar protein homolog , UBA1, ubiquitin-activating enzyme E1 homolog A , ubiquitin-like modifier-activating enzyme 1 , Ubiquitin-conjugating enzyme E1 , ubiquitin-activating enzyme E1, Chr X , ubiquitin-activating enzyme E1 , ubiquitin activating enzyme , fb30f01 , ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing) , Poly(A)+ RNA transport protein 3

GENE ID SPECIES
7317 Homo sapiens
8617637 Dictyostelium discoideum AX4
5700601 Giardia lamblia ATCC 50803
5700939 Giardia lamblia ATCC 50803
22201 Mus musculus
282869 Bos taurus
314432 Rattus norvegicus
379877 Xenopus laevis
398370 Xenopus laevis
406335 Danio rerio
100009225 Oryctolagus cuniculus
480896 Canis lupus familiaris
2540744 Schizosaccharomyces pombe 972h-
100726349 Cavia porcellus
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