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ZMYND15 encodes a MYND-containing zinc-binding protein with a nuclear localization sequence. Additionally we are shipping and and many more products for this protein.
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Two candidate loci in each family and homozygous truncating mutations p.R611X in TAF4B in family 1 and p.K507Sfs*3 in ZMYND15 in family 2, were identified.
ZMYND15 represents the first transcriptional repressor identified to be essential for sperm production and male fertility.
This gene encodes a MYND-containing zinc-binding protein with a nuclear localization sequence. A similar gene in mice has been shown to act as a testis-specific transcriptional repressor by recruiting histone deacetylase enzymes to regulate spatiotemporal expression of many haploid genes. This protein may play an important role in spermatogenesis. Alternative splicing results in multiple transcript variants and protein isoforms.
zinc finger MYND domain-containing protein 15
, zinc finger, MYND domain containing 15
, zinc finger, MYND-type containing 15