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Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Additionally we are shipping aHSP Antibodies (45) and aHSP Kits (20) and many more products for this protein.
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In the presence of free alpha subunits and H2O2, both HbA (show SCN2A Proteins) and HbE (show HBe1 Proteins) showed bCys93 oxidation which increased with higher H2O2 concentrations. In the presence of Alpha-hemoglobin stabilizing protein (AHSP)Cys93 oxidation was substantially reduced in both proteins.in the presence of excess free alpha-subunit (show POLG Proteins) and under the same oxidative conditions, these events are substantially increased for HbE (show HBe1 Proteins) compared to HbA (show SCN2A Proteins)
Findings indicate that alpha-hemoglobin-stabilizing protein (AHSP) expression is a biomarker of hemoglobin (show HBB Proteins) H (HbH (show HBA1 Proteins)) disease severity and infer an important role of AHSP in modulating the pathophysiology of this disease.
AHSP is predominantly expressed in erythroid precursors in bone marrow biopsy specimens from patients with hematologic malignancies.
AHSP expression was higher in patients with sickle cell anemia versus thalassemia, with no significant difference between BTM and BTI. Expression was higher in patients with NTDT and on hydroxyurea therapy.
In maturing RBC (show CACNA1C Proteins) progenitors AHSP bind to free alpha-globin (show HBA1 Proteins) chains to increase the HbA (show SCN2A Proteins) production. (Review)
analysis showed binding of STAT3 (show STAT3 Proteins) to AHSP promoter and binding was significantly augmented with IL6 (show IL6 Proteins) stimulation and upon alpha-globin (show HBA1 Proteins) overexpression
The relationship between AHSP gene expression, disease severity, and the beta/alpha globin (show HBA1 Proteins) mRNA ratio was studied among different homozygote beta-thalassemia patients.
alpha-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy (show GCG Proteins)-alpha-hemoglobin and weakens the iron-oxygen bond.
alpha-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of alpha-subunits of human HbA (show SCN2A Proteins) with hydrogen peroxide.
AHSP acts as a molecular chaperone (show HSP90AA1 Proteins) by rapidly binding and stabilizing met-alpha hemichrome folding intermediates
role of alpha-hemoglobin stabilizing protein in hemoglobin assembly
Endogenous AHSP is not limiting for alpha-globin (show HBA-A1 Proteins) detoxification in beta-thalassemic mice.
activin A (show INHBA Proteins) does not appear to affect the exocrine or endocrine components of the pancreas, but promotes differentiation of pancreatic tissue into intestine via a Shh (show SHH Proteins)-dependent mechanism
Loss of AHSP impairs erythropoiesis and exacerbates beta-thalassemia.
These results support the hypothesis that EKLF (show KLF1 Proteins) acts as a transcription factor and a chromatin modulator for the AHSP and beta-globin (show HBB Proteins) genes and indicate that EKLF (show KLF1 Proteins) may play similar roles for other erythroid genes.
developmental stage- and differentiation state-specific regulation of the nuclear transport of EKLF (show KLF1 Proteins) might be one of the steps necessary for the switch-on of the mammalian adult beta globin (show HBB Proteins) gene transcription
AHSP also acts as a molecular chaperone to stabilize nascent alpha-globin for hemoglobin A assembly
The expression of AHSP in a subclone of murine erythroleukemia cells in relationship to prion protein (show PRNP Proteins) on the cell surface is reported.
Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation (By similarity).
alpha hemoglobin stabilizing protein
, erythroid associated factor
, alpha hemoglobin stabilising protein
, alpha-hemoglobin-stabilizing protein
, erythroid differentiation associated factor
, erythroid differentiation-related factor
, erythroid-associated factor