We are preparing the requested document. Please wait, this may take a while...!
|Antigen||Nucleotide-Binding Oligomerization Domain Containing 1 (NOD1) Antibodies|
|Conjugate||This NOD1 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|2 references available|
|Supplier||Log in to see|
Product Details anti-NOD1 AntibodyTarget Details NOD1 Application Details Handling References for anti-NOD1 antibody (ABIN453551) Images
|Specificity||This antibody recognizes CARD4 / NOD1 (C-term).|
|Cross-Reactivity (Details)||Species reactivity (tested):Human.|
|Purification||Affinity Chromatography on Protein A.|
|Immunogen||KLH conjugated synthetic peptide selected from the C-terminal region of Human CARD4. Genename: NOD1|
|Plasmids, Primers & others|
Target Details NOD1Product Details anti-NOD1 Antibody Application Details Handling References for anti-NOD1 antibody (ABIN453551) Images back to top
|Alternative Name||CARD4 / NOD1 (NOD1 Antibody Abstract)|
|Background||CARD4 is a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid.Synonyms: Caspase recruitment domain-containing protein 4, Nucleotide-binding oligomerization domain-containing protein 1|
|Molecular Weight||107691 Da|
|Pathways||Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades|
Application DetailsProduct Details anti-NOD1 Antibody Target Details NOD1 Handling References for anti-NOD1 antibody (ABIN453551) Images back to top
ELISA: 1/1,000. Western blotting: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-NOD1 Antibody Target Details NOD1 Application Details References for anti-NOD1 antibody (ABIN453551) Images back to top
|Buffer||PBS with 0.09 % (W/V) Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
References for anti-NOD1 antibody (ABIN453551)Product Details anti-NOD1 Antibody Target Details NOD1 Application Details Handling Images back to top
Inohara, Koseki, Lin, del Peso, Lucas, Chen, Ogura, Núñez: "An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways." in: The Journal of biological chemistry, Vol. 275, Issue 36, pp. 27823-31, 2000
Inohara, Koseki, del Peso, Hu, Yee, Chen, Carrio, Merino, Liu, Ni, Núñez: "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB." in: The Journal of biological chemistry, Vol. 274, Issue 21, pp. 14560-7, 1999
ImagesProduct Details anti-NOD1 Antibody Target Details NOD1 Application Details Handling References for anti-NOD1 antibody (ABIN453551) back to top