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|Antigen||Nucleotide-Binding Oligomerization Domain Containing 1 (NOD1) Antibodies|
|Epitope||AA 1-160 Alternatives|
|Reactivity||Human, Rat (Rattus) Alternatives|
|Conjugate||This NOD1 antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-NOD1 AntibodyTarget Details NOD1 Application Details Handling Images
|Purpose||Rabbit IgG polyclonal antibody for Nucleotide-binding oligomerization domain-containing protein 1(NOD1) detection. Tested with WB, IHC-P in Human,Rat.|
|Cross-Reactivity (Details)||No cross reactivity with other proteins.|
Rabbit IgG polyclonal antibody for Nucleotide-binding oligomerization domain-containing protein 1(NOD1) detection. Tested with WB, IHC-P in Human,Rat.
Gene Name: nucleotide-binding oligomerization domain containing 1
Protein Name: Nucleotide-binding oligomerization domain-containing protein 1
|Purification||Immunogen affinity purified.|
|Immunogen||E.coli-derived human CARD4 recombinant protein (Position: M1-M160). Human CARD4 shares 82% amino acid (aa) sequence identity with mouse CARD4.|
|Plasmids, Primers & others|
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|Alternative Name||NOD1 (NOD1 Antibody Abstract)|
Nucleotide-binding oligomerization domain-containing protein 1, also known as CARD4, is a protein receptor that in humans is encoded by the NOD1 gene. NOD1 is a member of NOD-like receptor protein family and is a close relative of NOD2. NOD1 is mapped to 7p14.3. It recognizes bacterial molecules and stimulates an immune reaction. NOD1 protein contains a caspase recruitment domain (CARD). This gene is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants, and mediates innate and acquired immunity by recognizing bacterial molecules containing D-glutamyl-meso-diaminopimelic acid (iE-DAP) moiety. What wore, it has been shown that NOD1 can sense cytosolic microbial products by monitoring the activation state of small Rho GTPases.
Synonyms: CARD 4 antibody|CARD4 antibody|Caspase recruitment domain 4 antibody|Caspase recruitment domain containing protein 4 antibody|Caspase recruitment domain family member 4 antibody|Caspase recruitment domain protein 4 antibody|Caspase recruitment domain-containing protein 4 antibody|CLR 7.1 antibody|CLR7.1 antibody|NLR family CARD domain containing 1 antibody|NLRC 1 antibody|NLRC1 antibody|NOD 1 antibody|Nod1 antibody|NOD1 protein antibody|NOD1_HUMAN antibody|Nucleotide binding oligomerization domain containing 1 antibody|Nucleotide binding oligomerization domain leucine rich repeat and CARD domain containing 1 antibody|Nucleotide-binding oligomerization domain-containing protein 1 antibody|Protein Nod1 antibody
|Pathways||Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades|
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Human, The detection limit for CARD4 is approximately 0.2 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
|Restrictions||For Research Use only|
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|Reconstitution||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|Buffer||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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