A synthetic peptide corresponding to a sequence at the C-terminal of mouse ADAMTS4 .Remarks: Sequence is different to the related rat sequence by three amino acids.
3830423K05 antibody, ADAM-TS4 antibody, ADAMTS-2 antibody, ADMP-1 antibody, mKIAA0688 antibody, ADAMTS-4 antibody, ADAMTS4 antibody, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 antibody, ADAM metallopeptidase with thrombospondin type 1 motif 4 antibody, ADAM metallopeptidase with thrombospondin type 1 motif, 4 antibody, Adamts4 antibody, ADAMTS4 antibody
Background
ADAM metallopeptidase with thrombospondin type 1 motif, 4, also known as ADAMTS4, is a human gene. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS is a novel family of extracellular proteases found in both mammals and invertebrates. Members of the family may be distinguished from the ADAM (adisintegrin and metalloprotease) family members based on the multiple copies of thrombospondin 1-like repeats they carry. Pratta et al. (2003) concluded that ADAMTS4 is constitutively produced in monolayer chondrocytes, capsular fibroblasts, and cartilage, and that stimulation by interleukin-1 results in aggrecanase activation. Thus, the activator could be a potential target by which to control aggrecanase-mediated degradation in arthritic diseases.Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS4, ADAMTS-4, ADMP-1, ADMP1, Aggrecanase-1, KIAA0688