CACNB3 antibody

Catalog No. ABIN1105625

Product Details anti-CACNB3 Antibody

Target: CACNB3 (Calcium Channel, Voltage-Dependent, beta 3 Subunit (CACNB3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CACNB3 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: Reacts with Human 54 kDa protein.

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography on Protein A

Immunogen: Synthetic peptide derived from CAB3 protein

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Restore in distilled water.

Buffer: 0.1 M Tris, 0.1 M Glycine and 2 % Sucrose, None

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store reconstituted antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CACNB3

Target: CACNB3 (Calcium Channel, Voltage-Dependent, beta 3 Subunit (CACNB3))

Alternative Name: CACNB3 (CACNB3 Products)

Synonyms: vgcc antibody, xo28 antibody, xo32 antibody, o32-a antibody, cacnlb3 antibody, VGCC antibody, CACNB3 antibody, CAB3 antibody, CACNLB3 antibody, Beta3 antibody, Cchb3 antibody, CACH3B antibody, cacnb3 antibody, Cacnb3 antibody, calcium channel, voltage-dependent, beta 3 subunit S homeolog antibody, calcium channel, voltage-dependent, beta 3 subunit L homeolog antibody, calcium voltage-gated channel auxiliary subunit beta 3 antibody, calcium channel, voltage-dependent, beta 3b antibody, calcium channel, voltage-dependent, beta 3 subunit antibody, calcium channel, voltage-dependent, beta 3a antibody, cacnb3.S antibody, cacnb3.L antibody, CACNB3 antibody, cacnb3b antibody, cacnb3 antibody, Cacnb3 antibody, cacnb3a antibody

Background: Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-ctx-GVIA) and omega-agatoxin-IVA (omega-aga-IVA). The overall conclusion is that deletion of the beta 3 subunit affects at least three distinct types of High voltage activated Ca2+ channel (L,N and P/Q types), but no single type of channel is solely dependent on beta 3.Synonyms: CAB3, CACNLB3, Calcium channel voltage-dependent subunit beta 3, Voltage-dependent L-type calcium channel subunit beta-3

Gene ID: 784

NCBI Accession: NP_000716

Pathways: Myometrial Relaxation and Contraction