SLC17A7 antibody (C-Term)

Catalog No. ABIN1109031

Product Details anti-SLC17A7 Antibody

Target: SLC17A7 (Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 7 (SLC17A7))

Binding Specificity: C-Term

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC17A7 antibody is un-conjugated

Application: Western Blotting (WB), Immunoelectron Microscopy (IEM), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts with Rat 55-60 kDa VGLUT1 protein of BON cells stably expressing VGLUT1 and of total Rat brain extracts. No cross reactivity was detected with VGLUT2 and VGLUT3.

Cross-Reactivity (Details): Species reactivity (tested):Rat.

Purification: Antigen Affinity Chromatography

Immunogen: A 17 residue synthetic peptide derived from C-terminal domain of Rat. Remarks: Vesicular Glutamate Transporter Type 1 (MW : 55-60 kD).

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: 0.1 M Tris, 0.1 M Glycine, Glycerol 50 % , pH 7.8, 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SLC17A7

Target: SLC17A7 (Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 7 (SLC17A7))

Alternative Name: SLC17A7 / VGLUT1 (SLC17A7 Products)

Synonyms: 2900052E22Rik antibody, AI851913 antibody, VGluT1 antibody, Vglut1 antibody, BNPI antibody, VGLUT1 antibody, slc17a7 antibody, vglut1 antibody, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 antibody, solute carrier family 17 member 7 antibody, solute carrier family 17 (vesicular glutamate transporter), member 7a antibody, Slc17a7 antibody, SLC17A7 antibody, slc17a7a antibody

Background: VGLUT1 is expressed in a subset of glutamate neurons and transports glutamate into native synaptic vesicles from the brain, exhibiting a conductance for chloride that is blocked by glutamate. Vesicular glutamate transport has a substantially lower apparent affinity than the plasma membrane excitatory amino acid transporters. Glutamate transport by VGLUT1 is saturated with a K(m) of approximately 2 mM, in the same range as transport by synaptic vesicles. Finally, plasma membrane glutamate transporters recognize both aspartate and glutamate as substrates, whereas VGLUT1 does not recognize aspartate.Synonyms: BNPI, Brain-specific Na(+)-dependent inorganic phosphate cotransporter, Solute carrier family 17 member 7, Vesicular glutamate transporter 1

Gene ID: 116638

NCBI Accession: NP_446311