Fibronectin antibody
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- Target See all Fibronectin Antibodies
- Fibronectin
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Reactivity
- Human, Mouse
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Fibronectin antibody is un-conjugated
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificity
- Recognizes Fibronectin specifically in connective tissues and vessels. No reactivity with the soluble dimeric form of Fibronectin (plasma Fibronectin), but highly reactive with matrix Fibronectin. Animal biodistribution experiments have shown that after intravenous administration, EP-5 antibody localizes to tumor vessels where it binds to the underlying basement membrane. At the same time the antigen recognized by EP-5 antibody is not accessible in normal tissue to circulating antibody indicating that this antibody can be used to target tumor vessels specifically in vivo.
- Cross-Reactivity (Details)
- Species reactivity (tested):Human, Mouse.
- Purification
- Protein A chromatography
- Immunogen
- Native human fibronectin (matrix)
- Clone
- EP5
- Isotype
- IgG1
- Top Product
- Discover our top product Fibronectin Primary Antibody
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- Application Notes
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Immunohistochemistry on frozen and paraffin embedded sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1,0 mg/mL
- Buffer
- PBS, pH 7.2, 0.09 % Sodium Azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C foor one month or (in aliquots) at -20 °C for longer.
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- Target
- Fibronectin
- Abstract
- Fibronectin Products
- Synonyms
- FN antibody, cig antibody, fibronectin antibody, finc antibody, lets antibody, msf antibody, CIG antibody, ED-B antibody, FINC antibody, FNZ antibody, GFND antibody, GFND2 antibody, LETS antibody, MSF antibody, E330027I09 antibody, Fn antibody, Fn-1 antibody, FIBNEC antibody, fn-1 antibody, fibronectin 1 antibody, FN1 antibody, fn1 antibody, Fn1 antibody
- Background
- Fibronectin is a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. They occur as dimers of two 250 kDa subunits. They have binding domains for bacterial proteins, collagens, heparin-like molecules and fibrin. Cellular fibronectin is widely distributed in the stroma of malignant tumours. Fibronectin is organized as a linear series of repeating modules which form domains for interaction with fibronectin itself, other matrix components (e.g. collagen and heparin) and receptors on cells (e.g. integrins).Synonyms: CIG, Cold-insoluble globulin, FN1
- Gene ID
- 2335
- NCBI Accession
- NP_002017
- UniProt
- P02751
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