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IFNB1 antibody

IFNB1 Reactivity: Human WB, IHC (p), EIA, Func Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN116507
  • Target See all IFNB1 Antibodies
    IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))
    Reactivity
    • 57
    • 20
    • 11
    • 9
    • 8
    • 7
    • 6
    • 5
    • 4
    • 3
    Human
    Host
    • 84
    • 19
    • 4
    • 2
    • 1
    Rabbit
    Clonality
    • 92
    • 17
    Polyclonal
    Conjugate
    • 57
    • 20
    • 13
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IFNB1 antibody is un-conjugated
    Application
    • 83
    • 52
    • 39
    • 25
    • 20
    • 14
    • 14
    • 11
    • 11
    • 11
    • 6
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA), Functional Studies (Func)
    Specificity
    This antibody detects Interferon-beta (IFN-beta).
    Cross-Reactivity (Details)
    Species reactivity (tested):Human.
    Purification
    Antigen Affinity Chromatography using immobilized IFN-beta matrix
    Immunogen
    Highly purified (>98%) E.coli derived recombinant Human Inferferon beta
    Top Product
    Discover our top product IFNB1 Primary Antibody
  • Application Notes
    Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity ofHuman IFN-beta (1.0 ng/mL), a concentration of 0.015-0.025 μg/mL of this antibody isrequired. Indirect ELISA: To detect Human IFN-beta by Indirect ELISA (using 100 μL/well antibodysolution) a concentration of 0.5-2.0 μg/mL of this antibody is required. In conjunction with compatible secondary reagents, it allows the detection of at least
    Restrictions
    For Research Use only
  • Reconstitution
    Restore in sterile water to a concentration of 0.1-1.0 mg/mL.
    Buffer
    PBS, pH 7.2 without preservatives
    Preservative
    Without preservative
    Handling Advice
    Avoid repeated freezing and thawing. Centrifuge vial before opening.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.
  • Target
    IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))
    Alternative Name
    IFNB / Interferon beta (IFNB1 Products)
    Synonyms
    IFB antibody, IFF antibody, IFNB antibody, IFN-beta antibody, Ifb antibody, Ifnb antibody, IFNb antibody, interferon beta 1 antibody, interferon beta 1, fibroblast antibody, interferon, beta 1, fibroblast antibody, IFNB1 antibody, Ifnb1 antibody
    Background
    The mammalian type I Inteferons (IFN1) are produced in response to viral infection and other inducers. They are divided into alpha and beta subtypes leukocytes and fibroblasts reactivity. The human IFN alphas are encoded by a family of at least 15 different genes, while IFN beta is the unique member of its subtype. There is approximately 50 % amino acid homology between the alpha and beta subtypes. Both IFN subtypes are pleiotropic cytokines and have a similar range of biological activities. Differences between alpha subtypes, and between IFN alpha and betas, are in potency and cell type specific activities. In particular, IFN beta elicits a markedly higher antiproliferation response in some cell types such as, embryonal carcinoma, melanoma and melanocytes than do IFN alphas. Higher potency of IFN beta in treatment of multiple sclerosis and certain cancers has been observed. Type I IFNs signal through binding to a common cell surface receptor. Two chains of the receptor, IFNAR1 and IFNAR2, have been identified. Both chains are necessary for function and in the absence of either there is neither high affinity binding nor biological activity. The intracellular portions of the receptor subunits are bound by tyrosine kinases, Jak1 and Tyk2, members of the Janus kinase family. Upon ligand binding these kinases are activated and phosphorylate members of the STAT family of transcription factors, as well as IFNAR1 and 2.Synonyms: Fibroblast interferon, IFB, IFN-beta, IFNB1
    Gene ID
    3456
    NCBI Accession
    NP_002167
    UniProt
    P01574
    Pathways
    JAK-STAT Signaling, TCR Signaling, TLR Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Autophagy, Inflammasome
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