MEFV antibody (AA 2-29)

Catalog No. ABIN1169260

Product Details anti-MEFV Antibody

Target: MEFV (Mediterranean Fever (MEFV))

Binding Specificity: AA 2-29

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MEFV antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Specificity: Recognizes human pyrin.

Cross-Reactivity: Human

Immunogen: Synthetic peptide corresponding to aa 2-29 (A2KTPSDHLLSTLEELVPYDFEKFKFKLQ29) of human pyrin.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

References for anti-MEFV antibody (ABIN1169260)

Papin, Cuenin, Agostini, Martinon, Werner, Beer, Grütter, Grütter, Tschopp: "The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing." in: Cell death and differentiation, Vol. 14, Issue 8, pp. 1457-66, (2007) (PubMed).

Target Details for MEFV

Target: MEFV (Mediterranean Fever (MEFV))

Alternative Name: Pyrin (MEFV Products)

Synonyms: pyrin antibody, MEFV antibody, FMF antibody, MEF antibody, TRIM20 antibody, rfp domain antibody, MEFV, pyrin innate immunity regulator antibody, Mediterranean fever antibody, MEFV antibody, Mefv antibody

Background: Pyrin regulates inflammation by interacting with the cytoskeleton. Pyrin may direct the migration of white blood cells to sites of inflammation and stop or slow the inflammatory response when it is no longer needed. Defects in pyrin are the cause for Mediterranean fever.

UniProt: O15553

Pathways: Positive Regulation of Endopeptidase Activity