PIDD antibody

Catalog No. ABIN1169269

This Mouse Monoclonal antibody specifically detects PIDD in WB. It exhibits reactivity toward Mouse.

Quick Overview for PIDD antibody (ABIN1169269)

Target: PIDD (P53-Induced Death Domain Protein (PIDD))

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This PIDD antibody is un-conjugated

Application: Western Blotting (WB)

Clone: Lise-1

Product Details anti-PIDD Antibody

Purpose: anti-PIDD (mouse), mAb (Lise-1)

Specificity: Recognizes mouse PIDD.

Characteristics: Monoclonal Antibody. Recognizes mouse PIDD. Isotype: Mouse IgG2bkappa. Clone: Lise-1. Applications: WB. Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide. PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.

Purification: Purified from concentrated hybridoma tissue culture supernatant.

Purity: >95 % (SDS-PAGE)

Immunogen: Mouse PIDD (Death Domain).

Isotype: IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

Target Details for PIDD

Target: PIDD (P53-Induced Death Domain Protein (PIDD))

Alternative Name: PIDD

Background:

Alternate Names/Synonyms: p53-induced Protein with a Death Domain, Leucine-rich Repeat and Death Domain-containing Protein, Lrdd

Product Description: PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.

UniProt: Q9ERV7

Pathways: p53 Signaling, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity