IFNB1 antibody

Catalog No. ABIN121882

This Rabbit Polyclonal antibody specifically detects IFNB1 in WB, IP and Func. It exhibits reactivity toward Chicken.

Quick Overview for IFNB1 antibody (ABIN121882)

Target: IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))

Reactivity: Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFNB1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Functional Studies (Func)

Product Details anti-IFNB1 Antibody

Specificity: This antibody recognizes Interferon beta (chIFN-beta). This antibody does not cross react with IFN gamma. This antiserum neutralizes chIFN-beta and can be used to discriminate IFN alpha and IFN beta bioactivities.

Characteristics: Synonyms: IFN-beta, IFNB1, IFB, Fibroblast interferon

Purification: Affinity chromatography on protein G

Immunogen: Recombinant chicken Interferon Beta

Application Details

Application Notes: Immunoprecipitation. Western Blot: This antibody detects a band of approximately 20 kDa. Funktional Assays.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS

Preservative: Azide free

Storage: -20 °C

Storage Comment: Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for IFNB1

Target: IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))

Alternative Name: IFNB / Interferon beta

Background: Reports suggest that chIFN exhibits properties similar to mammalian IFN type I (IFNI). Functional studies revealed the presence of two distantly related IFNI genes, designated as IFN alpha and IFN beta, found on chicken chromosome Z. The serological distinction between these two IFNs has been verified using neutralisation assays, and there is evidence that the antiviral activity of chIFN-beta is approximately tenfold less compared to chIFN-alpha. This would suggest that chIFNbeta might have a different physiological role, though chIFN-beta is expressed strongly in virus-infected cells.Synonyms: Fibroblast interferon, IFB, IFN-beta, IFNB1

Gene ID: 554219

UniProt: Q90873

Pathways: JAK-STAT Signaling, TCR Signaling, TLR Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Autophagy, Inflammasome