PAWR antibody

Catalog No. ABIN127126

Product Details anti-PAWR Antibody

Target: PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAWR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Specificity: The antibody recognizes PAR4.

Purification: Peptide affinity purified

Immunogen: Synthetic peptide surrounding amino acid 327 of human Par4.

Application Details

Application Notes: Western Blot: 1-4 μg/mL. Immunoprecipitation: 20 μg/mL. Immunohistochemistry: 20 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: PBS containing 50 % glycerol, 1 % BSA, and 0.02 % thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C/-80 °C

Storage Comment: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.

Target Details for PAWR

Target: PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))

Alternative Name: PAR4 / PAWR (PAWR Products)

Synonyms: MGC81382 antibody, pawrl antibody, zgc:103513 antibody, PAWR antibody, PAR4 antibody, Par-4 antibody, Par4 antibody, 2310001G03Rik antibody, pro-apoptotic WT1 regulator antibody, PRKC, apoptosis, WT1, regulator L homeolog antibody, PRKC, apoptosis, WT1, regulator antibody, PAWR antibody, pawr.L antibody, pawr antibody, Pawr antibody

Background: Five ionomycin-inducible complementary cDNAs, designated PAR1, 2, 3, 4 and 5, have been isolated from the prostate cancer cell line AT-3. Nucleotide sequencing identified PAR1 as the rat homolog of MKP-1, PAR2 as the injury-inducible gene HB-EGF, and PAR3 as the serum-induced gene cyr-61. PAR4 and PAR5 sequences were not found to correspond to any previously described proteins. PAR4 (prostate apoptosis response-4) is specifically expressed by cells entering apoptosis and is not inducible by growth factor stimulation, oxidative stress and necrosis, or growth arrest. The PAR4 gene encodes a 38 kDa protein with a putative nuclear localization signal and carboxy terminal leucine zipper.Synonyms: PRKC apoptosis WT1 regulator protein, Par-4, Prostate apoptosis response 4 protein

Gene ID: 5074

NCBI Accession: NP_002574

UniProt: Q96IZ0