Tyrosine Hydroxylase antibody (pSer40)

Catalog No. ABIN127280

Product Details anti-Tyrosine Hydroxylase Antibody

Target: Tyrosine Hydroxylase (TH)

Binding Specificity: pSer40

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Tyrosine Hydroxylase antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificity: The antibody detects a ~60 kDa Tyrosine Hydroxylase when phosphorylated at Ser40.

Purification: Affinity purified

Immunogen: Synthetic phospho-peptide from human Tyrosine Hydroxylase

Application Details

Application Notes: Western Blot: 1: 200-1000. Immunofluorescence: 1: 50-100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.2, containing 50 % glycerol, 1 % BSA, 0.02 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C/-80 °C

Storage Comment: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.

Target Details for Tyrosine Hydroxylase

Target: Tyrosine Hydroxylase (TH)

Alternative Name: Tyrosine 3-Monooxygenase (TH) (TH Products)

Synonyms: DYT14 antibody, DYT5b antibody, TYH antibody, The antibody, CG10118 antibody, DH65B antibody, DTH antibody, Dmel\\CG10118 antibody, Pale antibody, Ple antibody, TH antibody, Th antibody, VII antibody, dTH1 antibody, dTH65B antibody, pale/ple antibody, th antibody, dyt14 antibody, dyt5b antibody, tyh antibody, tyrosine hydroxylase antibody, pale antibody, tyrosine 3-monooxygenase antibody, tyrosine hydroxylase S homeolog antibody, TH antibody, Th antibody, ple antibody, th antibody, th.S antibody, LOC100008895 antibody

Background: Tyrosine hydroxylase play an important role in the synthesis of dopamine and other catecholamines. The enzymes activity is regulated in the level of transcription and translation, as well as posttranscriptional modifications. Phosphorylation at Ser40 may play a key role in regulation of the catalytic activity of the enzyme.Synonyms: TYH, Tyrosine 3-hydroxylase

Gene ID: 7054

NCBI Accession: NP_000351

UniProt: P07101

Pathways: Dopaminergic Neurogenesis, Response to Water Deprivation, Sensory Perception of Sound, Carbohydrate Homeostasis, Feeding Behaviour