c-MET antibody

Catalog No. ABIN1381745

Product Details anti-c-MET Antibody

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This c-MET antibody is un-conjugated

Application: Flow Cytometry (FACS), Cell-ELISA (cELISA)

Specificity: Anti-human c-Met

Characteristics: Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells

Purification: Protein G

Immunogen: genetic immunisation with cDNA encoding human c-Met

Clone: BCI-3E7

Isotype: IgG2b kappa

Application Details

Application Notes: Flow cytometry: 1.2 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.

Restrictions: For Research Use only

Handling

Buffer: PBS, pH 7.2

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C

Storage Comment: short term: 2 °C - 8 °C, long term: -20 °C

Target Details for c-MET

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Alternative Name: c-Met (MET Products)

Synonyms: AUTS9 antibody, HGFR antibody, RCCP2 antibody, c-Met antibody, AI838057 antibody, HGF antibody, Par4 antibody, Hgfr antibody, c-met antibody, MET antibody, C-MET antibody, met antibody, met-A antibody, MET proto-oncogene, receptor tyrosine kinase antibody, met proto-oncogene antibody, MET proto-oncogene, receptor tyrosine kinase L homeolog antibody, MET antibody, Met antibody, met.L antibody

Background: C-MET is a receptor tyrosine kinase that is activated upon Hepatocyte Growth Factor (HGF) binding. c-MET is produced as a single-chain precursor and plays en essential role in embryonic development and wound healing. It belongs to the class of Single-pass type I membrane proteins and it is normally expressed by cells of epithelial origin while the expression of HGF is restricted to cells of mesenchymal origin in an almost perfect paracrine paradigm. Overexpression of c-MET can be found in several kinds of tumor progression.

UniProt: P08581

Pathways: RTK Signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor