SAG antibody (AA 285-330)

Catalog No. ABIN1387479

Product Details anti-SAG Antibody

Target: SAG (S-Antigen, Retina and Pineal Gland (Arrestin) (SAG))

Binding Specificity: AA 285-330

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SAG antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Retinal S antigen

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for SAG

Target: SAG (S-Antigen, Retina and Pineal Gland (Arrestin) (SAG))

Alternative Name: Retinal S antigen/S-antigen (SAG Products)

Synonyms: RP47 antibody, S-AG antibody, MGC75721 antibody, MGC84416 antibody, sag antibody, zgc:114197 antibody, SAGMR antibody, SANTI antibody, ARR antibody, sag1 antibody, A930001K18Rik antibody, Arr1 antibody, Irbp antibody, arrestin antibody, S-antigen visual arrestin antibody, S-antigen antibody, S-antigen; retina and pineal gland (arrestin) antibody, S-antigen; retina and pineal gland (arrestin) S homeolog antibody, S-antigen; retina and pineal gland (arrestin) b antibody, S-antigen, retina and pineal gland (arrestin) antibody, S-antigen; retina and pineal gland (arrestin) L homeolog antibody, SAG antibody, PF10_0343 antibody, sag antibody, sag.S antibody, sagb antibody, Sag antibody, sag.L antibody

Background:

Synonyms: 48 kDa protein, Arrestin 1, Arrestin, ARRS_HUMAN, DKFZp686I1383, Retinal S antigen 48 KDa protein, Retinal S-antigen, Rod photoreceptor arrestin, RP47, S AG, S antigen, S antigen retina and pineal gland arrestin, S antigen retina and pineal gland, S arrestin, S-AG, S-arrestin, SAG.

Background: Plasmodium falciparum is a protozoan parasite that causes malaria. It exhibits considerable antigenic heterogeneity which may be a major problem in developing an effective vaccine against malaria. The S-antigen of Plasmodium falciparum is a highly diverse, heat stable protein that is located in the parasitophorous vacuole of the mature asexual intraerythrocytic parasite. The S-antigen gene consists of multiple alleles that originate from the same chromosome site. The amino acid sequence of each allele contains a large central section of tandemly arranged, nearly identical peptides that are specific to each allele. Thus, directed against the repeat region of a particular allele can be used to define the serotype of an S-antigen. Flanking the central repeat block are two short regions of non-repetitive sequence which occur in four different forms, each of which is utilized to define a single S-antigen family. Comparison of the four S-antigen families reveals t hat they differ considerably from each other with variation being most pronounced in the C-terminal-flanking region.

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling