PPP2R2B antibody (AA 51-130) (Biotin)

Catalog No. ABIN1393093

Product Details anti-PPP2R2B Antibody (Biotin)

Target: PPP2R2B (Protein Phosphatase 2, Regulatory Subunit B, beta (PPP2R2B))

Binding Specificity: AA 51-130

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP2R2B antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Sheep,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PPP2R2B/PP2A-B55

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for PPP2R2B

Target: PPP2R2B (Protein Phosphatase 2, Regulatory Subunit B, beta (PPP2R2B))

Alternative Name: PPP2R2B/PP2A-B55 (PPP2R2B Products)

Synonyms: B55BETA antibody, PP2AB55BETA antibody, PP2ABBETA antibody, PP2APR55B antibody, PP2APR55BETA antibody, PR2AB55BETA antibody, PR2ABBETA antibody, PR2APR55BETA antibody, PR52B antibody, PR55-BETA antibody, PR55BETA antibody, SCA12 antibody, Pppr2b2 antibody, 2900026H06Rik antibody, 6330404L05Rik antibody, E130009M08Rik antibody, PP2A-PR55B antibody, PP2A antibody, ppp2r2b-a antibody, ppp2r2c antibody, ppp2r2b antibody, zgc:101861 antibody, PPP2R2B antibody, protein phosphatase 2 regulatory subunit Bbeta antibody, protein phosphatase 2, regulatory subunit B, beta antibody, protein phosphatase 2 regulatory subunit B, beta L homeolog antibody, protein phosphatase 2 regulatory subunit B, beta antibody, protein phosphatase 2, regulatory subunit B, beta b antibody, PPP2R2B antibody, Ppp2r2b antibody, ppp2r2b.L antibody, ppp2r2b antibody, ppp2r2bb antibody

Background:

Synonyms: 2ABB_HUMAN; B55 beta; Beta isoform of regulatory subunit B55 protein phosphatase 2; MGC24888; PP2A B Subunit B Alpha Isoform; PP2A B55beta; PP2A PR55B; PP2A subunit B B beta isoform; PP2A subunit B B55 beta isoform; PP2A subunit B isoform B55 beta; PP2A subunit B isoform B55-beta; PP2A subunit B isoform beta; PP2A subunit B isoform PR55 beta; PP2A subunit B isoform PR55-beta; PP2A subunit B isoform R2 beta; PP2A subunit B isoform R2-beta; PP2A subunit B PR55 beta isoform; PP2A subunit B R2 beta isoform; Ppp2r2b; PR2AB beta; PR2AB55 beta; PR2APR55 beta; PR52B; PR55 beta; Protein phosphatase 2 formerly 2A regulatory subunit B PR 52 beta isoform; Protein phosphatase 2 formerly 2A regulatory subunit B beta isoform; Protein phosphatase 2 regulatory subunit B; Protein phosphatase 2 regulatory subunit B beta isoform; SCA 12; SCA12; Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; Serine/Threonine Protein Phosphatase 2A 56kDa Regulatory Subunit Alpha Isoform; Serine/threonine protein phosphatase 2A neuronal isoform; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform.

Background: In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family. The PP2A family comprises subfamily members PP2Aå and PP2A. The PP2A catalytic subunit associates with a variety of regulatory subunits. The B family of regulatory subunits (including B55, B56 and PR72/130 subfamilies) is believed to participate in substrate specificity and catalytic activity. PP2A-B55, also known as PP2A regulatory subunit subfamily B55 or PP2A-B1, is a B subfamily consisting of four B55 isoforms (Alpha,Beta, Gamma and Delta) encoded by four distinct genes.

Pathways: PI3K-Akt Signaling, Mitotic G1-G1/S Phases, Hepatitis C