NR2E1 antibody (AA 351-385) (Cy5.5)
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- Target See all NR2E1 Antibodies
- NR2E1 (Nuclear Receptor Subfamily 2, Group E, Member 1 (NR2E1))
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Binding Specificity
- AA 351-385
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NR2E1 antibody is conjugated to Cy5.5
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Application
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Predicted Reactivity
- Human,Mouse,Rat,Dog,Cow,Chicken,Rabbit
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human NR2E1/Tailless
- Isotype
- IgG
- Top Product
- Discover our top product NR2E1 Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- NR2E1 (Nuclear Receptor Subfamily 2, Group E, Member 1 (NR2E1))
- Alternative Name
- NR2E1/Tailless (NR2E1 Products)
- Synonyms
- NR2E1 antibody, TLL antibody, TLX antibody, XTLL antibody, Mtl1 antibody, Mtll antibody, Tlx antibody, fierce antibody, frc antibody, tailless antibody, fc30e03 antibody, fc39f12 antibody, wu:fc30e03 antibody, wu:fc39f12 antibody, zgc:100991 antibody, Xtll antibody, nr2e1-A antibody, tlx antibody, nuclear receptor subfamily 2 group E member 1 antibody, nuclear receptor subfamily 2, group E, member 1 antibody, nuclear receptor subfamily 2 group E member 1 S homeolog antibody, NR2E1 antibody, Nr2e1 antibody, nr2e1 antibody, nr2e1.S antibody
- Background
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Synonyms: hTll, nr2e1, NR2E1_HUMAN, Nuclear receptor subfamily 2 group E member 1, Nuclear receptor TLX, Orphan nuclear receptor NR2E1, Protein tailless homolog, Tailless homolog, Tll, TLX, XTLL.
Background: NR2 proteins are a large family of nuclear hormone receptor transcription factors. The proteins belonging to this family are characterized by discrete domains functioning in DNA and ligand binding. NR2E1 (nuclear receptor subfamily 2, group E, member 1), also known as TLX, is an essential component in the formation of synaptic plasticity and dendritic structure in retinal astrocytes. In addition, NR2E1 is a orphan receptor that binds DNA as part of the hormone response element (HRE), a transcription regulator for hormones. DNA-binding orphan receptors have the conserved sequence 5'-AAGGTCA-3', a motif that determines substrate binding specificity. NR2E1 is expressed in brain tissue, with highest levels in astrocytes, and is localized to the nucleus. Mutations in the gene that encodes NR2E1 may lead to retinal dystrophy, a disorder characterized by a reduction in the thickness of the retina.
- Pathways
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Stem Cell Maintenance
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