Anti-mouse Bcl-3 monoclonal antibody reacts with both mouse and human Bcl-3 B-cell Leukemia/lymphoma 3). The proto-oncoprotein Bcl-3 is a member of the IkappaB family and is present predominantly in the nucleus. This protein has been shown to function as a transcriptional co-activator for homodimers of NF-kappaB p50 and p50B. In addition to p50 and p52, Bcl-3 also associates with nuclear proteins Jab1, Pirin, Tip60 and Bard1. The mouse Bcl-3 coding region exhibits 80% homology with human Bcl-3 which is associated with human B-cell chronic lymphocytic leukemias (CLLs). Bcl-3 is detected in various tissues such as spleen and other lymphoid organs. Applications for this clone include Western blotting, ELISA and flow cytometry.